Salbutamol sulfate suppositories: Influence of formulation on physical parameters and stability

Pharmaceutical Development and Technology

Volumn 8, Issue 1, 2003, Pages 21-30

  Taha, Ehab I ^a   Zaghloul, Abdel Azim A ^a,b   Kassem, Alaa A ^a   Khan, Mansoor A ^b  

^a Al Azhar University   (Egypt)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

First pass metabolism; Gels; Salbutamol sulfate; Suppository bases

Indexed keywords

MACROGOL; METHYLCELLULOSE; SALBUTAMOL SULFATE; SUPPOCIRE; SUPPOSITORY BASE; WITEPSOL;

ARTICLE; DRUG ANALYSIS; DRUG DEGRADATION; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; FIRST PASS EFFECT; GEL; HARDNESS; MELTING POINT; MOLECULAR WEIGHT; PRIORITY JOURNAL; SHELF LIFE;

ALBUTEROL; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; DRUG STABILITY; SUPPOSITORIES;

EID: 0037235078     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-120017520     Document Type: Article

References (25)

1. Ewoud, J.H.; Albertus, G.B.; Douwe, D.B. Pharmacokinetics of rectal drug administration, part I. General considerations and clinical applications of centrally acting drugs. Clin. Pharmacokinet. 1991, 21 (1), 11-26.
2. de Boer, A.G.; Moolenaar, F.; de Leede, L.G.; Breimer, D.D. Rectal drug administration, clinical pharmacokinetic considerations. Clin. Pharmacokinet. 1982, 7, 285-311.
3. Ewoud, J.H.; Albertus, G.B.; Douwe, D.B. Pharmacokinetics of rectal drug administration, Part II. Clinical applications of peripherally acting drugs, and conclusions. Clin. Pharmacokinet. 1991, 21 (2), 110-128.
4. Jay, M.; Beihm, R.M.; Digenis, G.A.; Deland, F.A.; Coldwell, L.; Mlodozeniec, A.R. Disposition of radio-labelled suppositories in humans. J. Pharm. Pharmacol. 1985, 37, 266.
5. de Leede, L.G.; De Boer, A.G.; Roozen, C.P.; Breimer, D.D. Avoidance of "first-pass" elimination of rectally administered lidocaine in relation to the site of absorption in rats. J. Pharmacol. Exp. Ther. 1983, 225 (1), 181-185.
6. Takada, K.; Yoshimura, H.; Shibata, N.; Masuda, Y.; Yoshikawa, H.; Muranish, S.; Yasumura, T.; Oka, T. Effect of administration route on the selective lymphatic delivery of Cyclosporin A by lipid-surfactant mixed micelles. J. Pharmacobio-Dyn. 1986, 9 (2), 156-160.
7. de Boer, A.G.; Breimer, D.D.; Mattie, H.; Pronk, J.; Gubbens-Stibbe, J.M. Rectal bioavailability of lidocaine in man: partial avoidance of "first-pass" metabolism. Clin. Pharmacol. Ther. 1979, 26 (6), 701-709.
8. Magnussen, I.; Oxlund, H.W.; Alsbirk, K.E.; Arnold, E. Absorption of diazepam in man following rectal and parentral administration. Acta Pharmacol. Toxicol. (Copench) 1979, 45, 87-90.
9. Kwan, K.C.; Breault, G.O.; Umbenhauer, E.R.; McMahon, F.G.; Duggan, D.E. Kinetics of indomethacin absorption, elimination, and enterohepatic circulation in man. J. Pharmacokinet. Biopharm. 1976, 4, 255-280.
10. Bolme, P.; Edlund, P.O.; Eriksson, M.; Paalzow, L.; Winbladh, B.P. Pharmacokinetics of theophylline in young children with asthma, comparison of rectal enema and suppositories. Eur. J. Clin. Pharmacol. 1979, 16 (2), 133-139.
11. de Boer, A.G.; De Leede, L.G.; Breimer, D.D. Drug absorption by sublingual and rectal routes. Br. J. Anaesth. 1984, 56 (1), 69-82.
12. de Boer, A.G.; Breimer, D.D.; Gubbens-Stibbe, J.M.; Bosma, A. First-pass elimination of salicylamide in man following oral and rectal administration. Biopharm. Drug Dispos. 1983, 4 (4), 321-330.
13. de Boer, A.G.; Gubbens-Stibbe, J.M.; Breimer, D.D. Avoidance of first-pass elimination of propranolol after rectal administration to rats. J. Pharm. Pharmacol. 1981, 33 (1), 50-51.
14. Morgan, D.J.; Paull, J.D.; Richmond, B.H.; Wilson-Evered, E.; Ziccone, S.P. Pharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate. Br. J. Clin. Pharmacol. 1986, 22, 587-593.
15. Ogiso, T.; Twaki, M.; Tanino, T.; Fujii, J.; Paku, T. Rectal absorption of ayclovir in rats and improvement of absorption by triglyceride base. Biol. Pharm. Bull. 1993, 16 (3), 315-318.
16. Umejima, H.; Kim, N.S.; Ito, T.; Uchida, T.; Goto, S. Preparation and evaluation of eudragit gels. VI: In vivo evaluation of eudispert rectal hydrogel and xerogel containing Salicylamide. J. Pharm. Sci. 1993, 82 (2), 195-199.
17. Umejima, H.; Kikuchi, A.; Kim, N.S.; Uchida, T.; Goto, S. Preparation and evaluation of eudragit gels. VIII: Rectal Absorption of 5-Fluorouracil from eudispert hv gels in rats. J. Pharm. Sci. 1995, 84 (2), 199-202.
18. Ansel, H.C.; Popovich, N.G. Pharmaceutical dosage forms and drug delivery systems; Lea & Fabiger: Philadelphia, London, 1990.
19. Service Bulletin on Eudispert Acryl Resin, Rohm. GMBH Weiterstadt, West Germany.
20. U.S.P. 2000, 24, 56.
21. Mahmoud, M.S. Formulation and optimization of certain dosage forms. Ph.D. Pharm. Thesis, Faculty of Pharmacy Al-Azhar University, Cairo, Egypt, 1999; 227.
22. Voigt, R.; Falk, G. Solubility of drugs as criterion for drug liberation from fat-like galenic bases (cetylium phthalicum, lasupol G) with reference to viscosity increasing adjuvant substances. Pharmazie 1968, 23 (12), 709-714.
23. Nixon, J.R.; Glorgakopuvlos, P.P.; Corless, J.E. Diffusion from gelatin-glycerin water gels. J. Pharm. Pharmacol. 1967, 19, 246-250.
24. Florence, A.T.; Attwood, D. Physicochemical principles of pharmacy, 3rd Ed.; Easton and Bristol: London, 1998; 441-446.
25. Abd El-Bary, A.; Tayel, S.; Yehia, S.; Osman, A. Bioavailability of salbutamol sulfate from different suppository formulations. Egypt J. Pharm. Sci. 1992, 33, 1031-1037.