Cytogenetics, FISH and RT-PCR analysis of acute promyelocytic leukemia: Structure of the fusion point in a case lacking classic t(15;17) translocation

Leukemia and Lymphoma

Volumn 44, Issue 1, 2003, Pages 111-115

  Fujita, Kazuhiro ^a   Oba, Remi ^a   Harada, Hiroshi ^a   Mori, Hiraku ^a   Niikura, Haruo ^a   Isoyama, Keiichi ^a   Omine, Mitsuhiro ^a  

^a SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

Author keywords

Acute promyelocytic leukemia; Chromosome aberration; Cytogenic analysis; Sequence analysis; Tretinoin

Indexed keywords

CYTARABINE; DAUNORUBICIN; DOXORUBICIN; ENOCITABINE; ETOPOSIDE; GENE PRODUCT; HYDROXYUREA; IDARUBICIN; MERCAPTOPURINE; MITOXANTRONE; PIRARUBICIN; PREDNISOLONE; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; CHIMERA; CHROMOSOME 15; CHROMOSOME 17; CHROMOSOME ANALYSIS; CHROMOSOME TRANSLOCATION 15; CHROMOSOME TRANSLOCATION 17; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; GENE INSERTION; HUMAN; INTRON; KARYOTYPE; LEUKEMIA REMISSION; LEUKEMOGENESIS; MALE; METAPHASE; MOLECULAR PROBE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; CHROMOSOMES, HUMAN, PAIR 15; CHROMOSOMES, HUMAN, PAIR 17; CYTOGENETIC ANALYSIS; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INTRONS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MALE; MIDDLE AGED; NEOPLASM PROTEINS; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; TRANSLOCATION, GENETIC; TRETINOIN;

EID: 0037234809     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/1042819021000040305     Document Type: Article

References (15)

1. Second MIC Cooperative Study Group(1988) "Morphologic, immunologic, and cytogenetic (MIC) working classification of the acute myeloid leukemias", Cancer Genetics and Cytogenetics 30, 1-15.
2. Mitelman, F. (1991) Catalog of Chromosome Aberrations in Cancer, 4th Ed. (Wiley-Liss, New York).
3. de Thé, H., Chomienne, C., Lanotte, M., Degos, L. and Dejean, A. (1990) "The t(15;17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor α gene to a novel transcribed locus", Nature 347, 558-561.
4. Kakizuka, A., Miller, Jr., W.H., Umesono, K., Warrell, Jr., R.P., Frankel, S.R., Murty, V.V.V.S., Domitrovsky, E. and Evans, R.M. (1991) "Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor PML", Cell 66, 663-674.
5. Lo Coco, F., Diverio, D., D'Adamo, F., Avvisati, G., Alimena, G., Nanni, M., Alcalay, M., Pandolfi, P.P. and Pelicci, P.G. (1992) "PML-RARα rearrangement in acute promyelocytic leukemias apparently lacking the t(15;17) translocation", European Journal of Haematology 48, 173-176.
6. Hiorns, L.R., Min, T., Swansbury, G.J., Zelent, A., Dyer, M.J.S. and Catovsky, D. (1994) "Interstitial insertion of retinoic acid receptor-α gene in acute promyelocytic leukemia with normal chromosome 15 and 17", Blood 83, 2946-2951.
7. Lafage-Pochitaloff, M., Alcalay, M., Brunel, V., Longo, L., Sainty, D., Simmonetti, J., Birg, F. and Pelicci, P.G. (1995) "Acute promylocytic leukemia cases with nonreciprocal PML/RARα or RARα/PML fusion gene", Blood 85, 1169-1174.
8. Grimwade, D., Biondi, A., Mozziconacci, M.J., Hagemeijer, A., Berger, R., Neat, M., Howe, K., Dastugue, N., Jansen, J., Radford-Weiss, I., Lo Coco, F., Lessard, M., Hernandez, J.M., Delabesse, E., Head, D., Liso, V., Sainty, D., Frandrin, G., Solomon, E., Birg, F. and Lafage-Pochitaloff, M. (2000) "Characterization of acute promylocytic leukemia cases lacking the classic t(15;17): results of the European Working Party", Blood 96, 1297-1308.
9. Biondi, A., Rambaldi, A., Pandolfi, P.P., Rossi, V., Giudici, G., Alcalay, M., Coco, F.L., Diverio, D., Pogliani, E.M., Lanzi, E.M., Mandelli, L.F., Masera, G., Barbui, T. and Pelicci, P.G. (1992) "Molecular monitoring of the myl/retinoic acid receptor-α fusion gene in aute promyelocytic leukemia by polymerase chain reaction", Blood 80, 492-497.
10. Pandolfi, P.P., Alcalay, M., Fagioli, M., Zangrilli, D., Mencarelli, A., Diverio, D., Biondi, A., Lo Coco, F., Rambaldi, A., Grignani, F., Rochette-Egly, C., Gaube, M-P., Chambon, P. and Pelicci, P.G. (1992) "Genomic variability and alternative splicing generate multiple PML-RARα transcripts that encode aberrant PML protein and PML-RARα isoforms in acute promyelocytic leukemia", European Molecular Biology Organization Journal 11, 1397-1407.
11. The Leukemia Study Group of the Ministry of Health and Welfare (Khoseisho)Fukutani, H., Naoe, T., Ohno, R., Yoshida, H., Miyawaki, S., Shimazaki, C., Miyake, T., Nakayama, Y., Kobayashi, H. and Goto, S. (1995) "Isoforms of PML-retinoic acid receptor alpha fused transcript affect neither clinical features of acute promyelocytic leukemia nor prognosis after treatment with all-trans retinoic acid", Leukemia 9, 478-1482.
12. Gallagher, R.E., William, C.L., Slack, J.L., Anderson, J.W., Li, Y.P., Viswanatha, D., Bloomfield, C.D., Appelbaum, F.R., Schiffer, C.A., Tallman, M.S. and Wiernik, P.H. (1997) "Association of PML-RAR alpha fusion mRNA type with pretreatment hematologic characteristics but not treatment outcome in acute promyelocytic leukemia: an intergroup molecular study", Blood 90, 1656-1663.
13. Bennet, J.M. (2000) "World Health Organization Classification of the acute leukemias and myelodysplastic syndrome", International Journal of Hematology 72, 131-133.
14. Mitelman, F. (1995) ISCN: An International System for Human Cytogenetic Nomanclature (Karger, Basel).
15. Inazawa, J., Nishigaki, H., Takahira, H., Nishimura, J., Horiike, S., Taniwaki, M., Misawa, S. and Abe, T. (1989) "Rejoining between 9q + and Philadelphia chromosome results in normal-looking chromosome 9 and 22 in Phl-negative chronic myelocytic leukemia", Human Genetics 83, 115-118.