Quantification of follicle stimulating hormone (follitropin alfa): Is in vivo bioassay still relevant in the recombinant age?

Current Medical Research and Opinion

Volumn 19, Issue 1, 2003, Pages 41-46

  Driebergen, R ^a   Baer, G ^b  

^a Industria Farmaceutica Serono SpA   (Italy)

^b Laboratoires Serono   (Switzerland)

Author keywords

Bioassay; Fill by mass; Follicle stimulating hormone, recombinant human; Follitropin alfa

Indexed keywords

RECOMBINANT FOLLITROPIN; RECOMBINANT FOLLITROPIN ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; DRUG ACTIVITY; DRUG CONTROL; DRUG DETERMINATION; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE DETERMINATION; ISOELECTRIC FOCUSING; METHODOLOGY; PHYSICAL CHEMISTRY; QUANTITATIVE ASSAY; RECOMBINANT DNA TECHNOLOGY;

BIOLOGICAL ASSAY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; FOLLICLE STIMULATING HORMONE; FOLLICLE STIMULATING HORMONE, HUMAN; HUMANS; HYPOGONADISM; ISOELECTRIC FOCUSING; MALE; OVULATION INDUCTION; RECOMBINANT PROTEINS;

EID: 0037234581     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079902125001344     Document Type: Article

References (8)

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4. Steelman SL, Pohley FM. Assay of the follicle stimulating hormone based on the augmentation with human chorionic gonadotropin. Endocrinology 1953;53:604-16
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6. Hugues J-N, et al. A new fill-by-mass manufacturing process for Gonal-F delivers a more consistent clinical response (Abstr O 225), 18th Congress of the European Society for Human Reproduction and Embryology, June 30-July 3, 2002, Vienna, Austria
7. oc manufacturing process translate into clinical benefits in ART, even at a 150 IU starting dose (Abstr). 12th World Congress on In vitro Fertilization and Molecular Human Reproduction, 16-19 March 2002, Buenos Aires, Argentina
8. oc filled-by-mass vs. r-hFSH filled by bioassay - a randomized, controlled trial (Abstr). 12th World Congress on in vitro Fertilization and Molecular Human Reproduction, 16-19 March 2002, Buenos Aires, Argentina