Sézary syndrome and related variants of classic cutaneous T-cell lymphoma. A descriptive and prognostic clinicopathologic study of 29 cases

Leukemia and Lymphoma

Volumn 44, Issue 1, 2003, Pages 59-69

  Marti, R M ^a,b   Pujol, R M ^c,f   Servitje, O ^d   Palou, J ^a   Romagosa, V ^d   Bordes, R ^c   Gonzalez Castro J ^a   Miralles, J ^c   Gallardo, F ^d,f   Curco N ^e   Gomez X ^b   Domingo, A ^d   Estrach, T ^a  

^a HOSPITAL CLÍNIC   (Spain)

^b UNIVERSITY OF LLEIDA   (Spain)

^c Hospital de la Sta ^*  (Spain)

^d HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^e HOSPITAL MÚTUA DE TERRASSA   (Spain)

^f Department of Dermatology   (Spain)

Author keywords

Clinicopathology; Lymphoma; S zary syndrome; Variant of T cell lymphoma

Indexed keywords

ANTINEOPLASTIC AGENT; BETA 2 MICROGLOBULIN; BLEOMYCIN; CD20 ANTIGEN; CD30 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETRETINATE; LACTATE DEHYDROGENASE; LEUKOSIALIN; PREDNISONE; VINCRISTINE;

ADNEXA DISEASE; ADULT; AGE; AGED; ARTICLE; BLOOD ANALYSIS; CANCER CLASSIFICATION; CANCER GRADING; CANCER INCIDENCE; CANCER INFILTRATION; CANCER PATIENT; CANCER SURVIVAL; CELL COUNT; CELL SIZE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CUTANEOUS T CELL LYMPHOMA; DERMATOLOGY; DISEASE CLASSIFICATION; DISEASE COURSE; EOSINOPHIL; FEMALE; GENDER; GRANULOMA; HISTOPATHOLOGY; HOSPITAL DEPARTMENT; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; LYMPHADENOPATHY; MALE; MITOSIS; PLASMA CELL; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; SEZARY CELL; SEZARY SYNDROME; SKIN BIOPSY; SKIN CELL; SKIN DEFECT; SPAIN; SYMPTOM; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; BLAST CRISIS; CELL SIZE; FEMALE; GENE REARRANGEMENT, T-LYMPHOCYTE; HUMANS; IMMUNOPHENOTYPING; LYMPHOMA, T-CELL, CUTANEOUS; MALE; MIDDLE AGED; PROGNOSIS; SEZARY SYNDROME; SKIN; SURVIVAL ANALYSIS;

EID: 0037232321     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/1042819021000054652     Document Type: Article

References (64)

1. Winkelmann, R.K. (1974) "Clinical studies of T-cell erythroderma in the Sézary syndrome", Mayo Clin. Proc. 49, 519-525.
2. Lamberg, S.I., Green, S.B., Byar, D.P., et al., (1984) "Clinical staging for cutaneous T-cell lymphoma", Ann. Intern. Med. 100, 187-192.
3. Sausville, E.A., Eddy, J.L., Makuch, R.W., et al., (1988) "Histopathologic staging at initial diagnosis of mycosis fungoides and the Sézary syndrome. Definition of three distinctive prognostic groups", Ann. Intern. Med. 109, 372-382.
4. Wieselthier, J.S. and Koh, H.K. (1990) "Sézary syndrome: diagnosis, prognosis and critical review of treatment options", J. Am. Acad. Dermatol. 22, 381-401.
5. Willemze, R., Kerl, H., Sterry, W., et al., (1997) "EORTC classification for primary cutaneous lymphomas: a proposal from the cutaneous lymphoma study group of the European organization for research and treatment of cancer", Blood 90, 354-371.
6. Buechner, S.A. and Winkelmann, R.K. (1983) "Sézary syndrome: a clinicopathologic study of 39 cases", Arch. Dermatol. 119, 979-986.
7. Le Boit, P.E. (1986) "Cutaneous lymphomas and their histopathologic imitators", Semin. Dermatol. 5, 322-333.
8. Sentis, H.J., Willemze, R. and Scheffer, E. (1986) "Histopathologic studies in Sézary syndrome and erythrodermic mycosis fungoides: a comparison with benign forms of erythroderma", J. Am. Acad. Dermatol. 15, 1217-1226.
9. Martí, R.M., Estrach, T., Reverter, J.C. and Mascaró, J.M. (1991) "Prognostic clinicopathologic factors in cutaneous T-cell lymphoma", Arch. Dermatol. 127, 1511-1516.
10. Kohler, S., Kim, Y.H. and Smoller, B.R. (1997) "Histologic criteria for the diagnosis of erythrodermic mycosis fungoides and Sézary syndrome: a critical reappraisal", J. Cutan. Pathol. 24, 292-297.
11. Trotter, M.J., Whittaker, S.J., Orchard, G.E., et al., (1997) "Cutaneous histopathology of Sézary syndrome: a study of 41 cases with a proven circulating T-cell clone", J. Cutan. Pathol. 24, 286-291.
12. Ralfkiaer, E. (1992) "Immunohistological markers for the diagnosis of cutaneous lymphomas", Semin. Diagn. Pathol. 8, 62-72.
13. Perkins, S.L. and Kjeldsberg, C.R. (1993) "Immunophenopyping of lymphomas and leukemias in paraffin-embedded tissues", Hematopathology 99, 362-373.
14. Ralfkiaer, E., Wollf-Sneedorff, A., Thomsen, K. and Vejlsgaard, G.L. (1993) "Immunophenotypic studies in cutaneous T-cell lymphomas: clinical implications", Br. J. Dermatol. 129, 655-659.
15. Slater, D.N. (1994) "Review of investigative techniques for cutaneous lymphomas", Semin. Dermatol. 13, 166-171.
16. Ritter, J.H., Adesokan, N.P., Fitzgibbon, J.F. and Wick, M.R. (1994) "Paraffin section immunohistochemistry as an adjunt to morphologic analysis in the diagnosis of cutaneous lymphoid infiltrates", J. Cutan. Pathol. 21, 481-493.
17. Cerroni, L. and Kerl, H. (1994) "The use of monoclonal antibodies on paraffin sections in the diagnosis of cutaneous lymphoproliferative disorders", Dermatol. Clin. 12, 219-229.
18. Estrach, T., Martí, R.M., Formigón, M. and Palou, J. (1995) "Utility of immunohistochemistry in the diagnosis of cutaneous lymphoma", Skin Cancer 10, 231-240.
19. Bernengo, M.G., Novelli, M., Quaglino, P., et al., (2001) "The relevance of the CD4+ CD26 - subset in the identification of circulating Sézary cells", Br. J. Dermatol. 144, 125-135.
20. Bogen, S.A., Pelley, D., Charif, M., et al., (1996) "Immunophenotypic identification of Sézary cells in peripheral blood", Am. J. Clin. Pathol. 106, 739-748.
21. Dummer, R., Nestle, F.O., Niederer, A., et al., (1999) "Genotypic and functional analysis of CD4+CD7+ and CD4+CD7 - T lymphocyte subsets in Sézary syndrome", Arch. Dermatol. Res. 291, 307-311.
22. Edelman, J. and Meyerson, H.J. (2000) "Diminished CD3 expression is useful for detecting and enumerating Sézary cells", Am. J. Clin. Pathol. 114, 467-477.
23. Aisenberg, A.C., Krontiris, T.G., Mak, T.W. and Wilkes, B.M. (1985) "Rearrangement of the gene fpr the beta chain of the T-cell receptor in T-cell chronic lymphocytic leukemia and related disorders", N. Engl. J. Med. 313, 529-533.
24. Weiss, L.M., Hu, E., Wood, G.S., et al., (1985) "Clonal rearrangements of T-cell receptor genes in mycosis fungoides and dermatopathic lymphadenopathy", N. Engl. J. Med. 313, 539-544.
25. Terhune, M.H. and Cooper, K.D. (1993) "Gene rearrangements and T-cell lymphomas", Arch. Dermatol. 129, 1484-1490.
26. Weinberg, J.M., Rook, A.H. and Lessin, S.R. (1993) "Molecular diagnosis of lymphocytic infiltrates of the skin", Arch. Dermatol. 129, 1491-1500.
27. Tillman, D.M. (1993) "Gene rearrangement studies in cutaneous lymphoma", Skin Cancer 8, 285-293.
28. Mielke, V., Staib, G., Boehncke, W-H., Duller, B. and Sterry, W. (1994) "Clonal disease in early cutaneous T-cell lymphoma", Dermatol. Clin. 12, 351-360.
29. Wood, G., Haeffner, A., Dummer, R. and Crooks, C.F. (1994) "Molecular biology techniques for the diagnosis of cutaneous T-cell lymphoma", Dermatol. Clin. 12, 231-241.
30. Volkenandt, M., Wienecke, R. and Tiemann, M. (1994) "Detection of monoclonal cell populations by polymerase chain reaction technology", Dermatol. Clin. 12, 341-349.
31. Bachelez, H., Bioul, L., Flageul, B., et al., (1995) "Detection of clonal T-cell receptor gamma gene rearrangements with the use of the polymerase chain reaction in cutaneous lesions of mycosis fungoides and Sézary syndrome", Arch. Dermatol. 131, 1027-1031.
32. Curcó, N., Servitje, O., Llucia, M., et al., (1997) "Genotypic analysis of cutaneous T-cell lymphoma: a comparative study of Southern blot analysis with polymerase chain reaction amplification of the T-cell receptor-gamma gene", Br. J. Dermatol. 137, 673-679.
33. Sézary, A. and Bouvrain, Y. (1938) "Erythroderma avec présence de cellules monstreuses dans la derme et le sang circulant", Bull. Soc. Fr. Dermatol. Syphiligr. 45, 254.
34. Bunn, P.A. and Lamberg, S.I. (1979) "Report on the committee of staging and classification of cutaneous T-cell lymphoma", Cancer Treat. Rep. 63, 725-728.
35. Clendenning, W.E. and Rappaport, W.H. (1979) "Report on the committee on pathology of cutaneous T-cell lymphomas", Cancer Treat. Rep. 63, 719-724.
36. Winkelmann, R.K., Diaz-Perez, J.L. and Buechner, S.A. (1984) "The treatment of Sézary syndrome", J. Am. Acad. Dermatol. 10, 1000-1004.
37. Besnier, E. and Hallopeau, H. (1892) "On the erythrodermia of mycosis fungoides", J. Cutan. Genito. Urin. Dis. 10, 453.
38. Kim, Y.H., Bishop, K., Varghese, A. and Hoppe, R.T. (1995) "Prognostic factors in erythrodermic mycosis fungoides and the Sézary syndrome", Arch. Dermatol. 131, 1003-1008.
39. Wosik, M.A., Vonderheid, E.C., Bigler, R.D., et al., (1996) "Increased serum concentration of the soluble interleukin-2 receptor in cutaneous T-cell lymphoma: clinical and prognostic implications", Arch. Dermatol. 132, 42-47.
40. Sausville, E.A., Eddy, J.L., Makuch, R.W., et al., (1988) "Histopathologic staging at initial diagnosis of mycosis fungoides and the Sézary syndrome. Definition of three distinctive prognostic groups", Ann. Intern. Med. 109, 372-382.
41. Martí, R.M., Estrach, T., Reverter, J.C., et al., (1996) "Utility of bone marrow and liver biopsies for staging cutaneous T-cell lymphoma", Int. J. Dermatol. 35, 450-454.
42. Picker, L.J., Terstappen, L.W.M.M., Rott, L.S., et al., (1990) "Differential expression of homing-associated adhesion molecules by T-cell subsites in man", J. Immunol. 145, 3247-3255.
43. Picker, L.J., Michie, S.A., Rott, L.S. and Butcher, E.C. (1990) "A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites", Am. J. Pathol. 136, 1053-1068.
44. Heald, P.W., Yan, S., Edelson, R.L., Tigelaar, R. and Picker, L.J. (1993) "Skin-selective lymphocyte homing mechanism in the pathogenesis of leukemic cutaneous T-cell lymphoma", J. Investig. Dermatol. 101, 222-226.
45. Boss, J.D., Boer, O.J., Tibosch, E., Das, P.K. and Pals, S.T. (1993) "Skin-homing T lymphocytes: detection of cutaneous lymphocyte-associated antigen (CLA) by HECA-452 in normal human skin", Arch. Dermatol. Res. 285, 179-183.
46. Hunger, R.E., Yawalkar, N., Braathen, L.R. and Brand, C.U. (1999) "The HECA-452 epitope is highly expressed on lymph cells derived from human skin", Br. J. Dermatol. 141, 565-569.
47. Robert, C. and Kupper, T.S. (1999) "Inflammatory skin diseases, T cells, and immune surveillance", N. Engl. J. Med. 341, 1817-1828.
48. Bunn, P.A., Hoffman, S.F., Norris, D., Golitz, L.E. and Aeling, J.L. (1994) "Systemic therapy of cutaneous T-cell lymphomas (mycosis fungoides and the Sézary syndrome)", Ann. Intern. Med. 121, 592-602.
49. Duvic, M., Hester, J.P. and Lemak, N.A. (1996) "Photopheresis therapy for cutaneous T-cell lymphoma", J. Am. Acad. Dermatol. 35, 573-579.
50. Zic, J.A., Stricklin, G.P., Greer, J.P., et al., (1996) "Long term follow-up of patients with cutaneous T-cell lymphoma treated with extracorporeal photochemotherapy", J. Am. Acad. Dermatol. 35, 935-945.
51. Gottlieb, S.L., Jonahtan, T.W., Fox, F.E., et al., (1996) "Treatment of cutaneous T-cell lymphoma with extracorporeal photopheresis monotherapy and in combination with recombinant interferon alfa: a 10 year experience at a single institution", J. Am. Acad. Dermatol. 35, 946-957.
52. Rusell-Jones, R. and Whittaker, S. (1999) "T-cell receptor gene analysis in the diagnosis of Sézary syndrome", J. Am. Acad. Dermatol. 41, 254-259.
53. Dommann, S.N., Dommann-Scherrer, C.C., Dours-Zimmermann, M.T., et al., (1996) "Clonal disease in extracutaneous compartments in cutaneous T-cell lymphomas. A comparative study between cutaneous T-cell lymphomas and pseudolymphomas", Arch. Dermatol. Res. 288, 163-167.
54. Toro, J.R., Stoll, H.L., Stomper, P.C. and Oseroff, A.R. (1997) "Prognostic factors and evaluation of mycosis fungoides and Sézary syndrome", J. Am. Acad. Dermatol. 37, 58-67.
55. Diamamdidou, E., Colome, M., Fayad, L., Duvic, M. and Kurzrock, R. (1999) "Prognostic factor analysis in mycosis fungoides/Sézary syndrome", J. Am. Acad. Dermatol. 40, 914-924.
56. Bernengo, M.G., Quaglino, P., Novelli, M., et al., (1998) "Prognostic factors in Sézary syndrome: a multivariate analysis of clinical, haematological and immunological features", Ann. Oncol. 9, 857-863.
57. Scarisbrick, J.J., Whittaker, S., Evans, A.V., et al., (2001) "Prognostic significance of tumor burden in the blood of patients with erythrodermic primary cutaneous T-cell lymphoma", Blood 97, 624-630.
58. Pereira, A., Cervantes, E., Montserrat, E., Llevaria, C. and Rozman, C. (1987) "Non-Hodgkin's lymphoma of unfavourable histology: a multivariate analysis predicting the response to CHOP", Hematol. Oncol. 5, 203-211.
59. Balch, C.M., Buzaid, A.C., Atkins, M.B., et al., (2000) "A new American joint committee on cancer staging system for cutaneous melanoma", Cancer 88, 1484-1491.
60. Grenier, J., Serrou, B., Suquet, P. and Pujol, H. (1978) "Comparison of the variations in levels of beta2-microglobulin and carcinoembryonic antigen in the breast cancer and malignant melanoma", Pathol. Biol. (Paris) 26, 371-372.
61. Oxholm, P. (1992) "Primary Sjogren's syndrome-clinical and laboratory markers of disease activity", Semin. Arthritis Rheum. 22, 114-126.
62. Lawn, S.D., Rudolph, D., Wiktor, S., Coulibaly, D., Ackah, A. and Lal, R.B. (2000) "Tuberculosis (TB) and HIV infection are independently associated with elevated serum concentrations of tumor necrosis factor receptor type 1 and beta2-microglobulin, respectively", Clin. Exp. Immunol. 122, 79-84.
63. Conconi, A., Zucca, E., Roggero, E., et al., (2000) "Prognostic models for diffuse large B-cell lymphoma", Hematol. Oncol. 18, 61-73.
64. Stadelman, W.K. and Reintgen, D.S. (1998) "Prognosis in malignant melanoma", Hematol. Oncol. Clin. N. Am. 12, 767-796.