A paradoxical effect of levetiracetam may be seen in both children and adults with refractory epilepsy

Seizure

Volumn 12, Issue 1, 2003, Pages 42-46

  Nakken, Karl ^a   Eriksson, Ann Sofie ^a   Lossius, Rasmus ^a   Johannessen, Svein I ^a  

^a National Centre for Epilepsy   (Norway)

Author keywords

Adults; Children; Epilepsy; Levetiracetam; Paradoxical effect

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLONAZEPAM; ETIRACETAM; LAMOTRIGINE; NITRAZEPAM; OXCARBAZEPINE; TOPIRAMATE; VALPROIC ACID;

ADD ON THERAPY; ADOLESCENT; ADULT; ARTICLE; ATAXIA; BEHAVIOR DISORDER; CHILD; CLINICAL STUDY; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFICACY; DRUG INDUSTRY; DRUG MECHANISM; DRUG TOLERABILITY; EPILEPTIC STATE; FEMALE; FOCAL EPILEPSY; FOLLOW UP; HEADACHE; HUMAN; INTRACTABLE EPILEPSY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MENTAL DEFICIENCY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PRURITUS; PSYCHOSIS; SEIZURE; SLEEP DISORDER; SOMNOLENCE; VERTIGO;

EID: 0037232175     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1059131102001723     Document Type: Article

References (10)

1. Klitgaard, H. Levetiracetam: the preclinical profile of a new class of antiepileptic drugs? Epilepsia 2001; 42 (Suppl. 4): S13-S18.
2. Noyer, M., Gillard, M., Matagne, A., Hénichart, J.-P. and Wülfert, E. The novel antiepileptic drug levetiracetam (ucb LO59) appears to act via a specific binding site in CNS membranes. European Journal of Pharmacology 1995; 286: 137-146.
3. Cereghino, J. J., Biton, V., Abou-khalil, B., Dreifuss, F., Gauer, L. J. and Leppik, I. Levetiracetam for partial seizures. Result of a double-blind, randomized clinical trial. Neurology 2000; 55: 236-242.
4. Shorvon, S. D., Löwenthal, A., Janz, D., Bielen, E. and Loiseau, P. Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures. Epilepsia 2000; 41: 1179-1186.
5. Bauer, J. Seizure-inducing effects of antiepileptic drugs-a review. Acta Neurologica Scandinavica 1996; 94: 367-377.
6. Perucca, E., Gram, L., Avanzini, G. and Dulac, O. Antiepileptic drugs as a cause of worsening of seizures. Epilepsia 1998; 39: 5-17.
7. Guerrini, R., Belmonte, A. and Genton, P. Antiepileptic drug-induced worsening of seizures in children. Epilepsia 1998; 39 (Suppl. 3): S2-S1O.
8. Neufeld, M. Y. Aggravation of seizures by antiepileptic drugs: pathophysiology and clinical implications. In: Brain Disease: Therapeutic Strategies and Repair (Eds O. Abramsky, D. A. S. Compston, A. Miller and G. Said). London, UK: Martin Dunitz Ltd., 2002: 251-255.
9. Bittencourt, P. R. M. and Richens, A. Anticonvulsant-induced status epilepticus in Lennox Gastaut Syndrome. Epilepsia 1981; 22: 129-134.
10. Di Mario Jr, F. J. and Calancy, R. R. Paradoxical precipitation of tonic seizures by lorazepam in a child with atypical absence seizures. Pediatric Neurology 1988; 4: 249-251.