New insight into the analysis of 6-[18F]fluoro-L-DOPA PET dynamic data in brain tissue without an irreversible compartment: Comparative study of the Patlak and Logan analyses

Radiation Medicine - Medical Imaging and Radiation Oncology

Volumn 21, Issue 1, 2003, Pages 47-54

  Kawatsu, Shoji ^a   Kato, Takashi ^a   Nagano Saito, Atsuko ^b   Hatano, Kentaro ^a   Ito, Kengo ^a   Ishigaki, Takeo ^c  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b CHUBU NATIONAL HOSPITAL   (Japan)

^c NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

FDOPA; Logan analysis; Patlak analysis; PET

Indexed keywords

6 FLUORODOPA F 18;

ADULT; AGED; ARTICLE; CEREBELLUM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC IMAGING; HUMAN; IMAGE ANALYSIS; OCCIPITAL CORTEX; PARKINSON DISEASE; POSITRON EMISSION TOMOGRAPHY; RADIOISOTOPE DISTRIBUTION; THEORETICAL MODEL;

AGED; BRAIN; CEREBELLAR CORTEX; DEMENTIA; DIHYDROXYPHENYLALANINE; FLUORINE RADIOISOTOPES; HUMANS; INJECTIONS, INTRAVENOUS; JAPAN; LINEAR MODELS; MIDDLE AGED; MODELS, THEORETICAL; OCCIPITAL LOBE; PARKINSON DISEASE; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0037231971     PISSN: 02882043     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Dhawan V, Ishikawa T, Patlak CS, et al. Combined FDOPA and 30MFD PET studies in Parkinson's disease. J Nucl Med, 37: 209-216, 1996.
2. Ishikawa T, Dhawan V, Chaly T, et al. Clinical significance of striatal DOPA decarboxylase activity in Parkinson's disease. J Nucl Med, 37: 216-222, 1996.
3. 18F-dopa PET shows bilaterally reduced striatal and nigral dopaminergic function in early Parkinson's disease. J Neurol Neurosurg Psychiatry, 66: 754-758, 1999.
4. 18F]dopa-PET study. Brain, 122: 1637-1650, 1999.
5. Nagano AS, Ito K, Kato T, et al. Extrastriatal mean regional uptake of fluoro-18-FDOPA in the normal aged brain-an approach using MRI-aided spatial normalization. Neuroimage, 11: 760-766, 2000.
6. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab, 3: 1-7, 1983.
7. Patlak CS, Blasberg RG. Graphical evaluation of blood-to- brain transfer constants from multiple-time uptake data generalizations. J Cereb Blood Flow Metab, 5: 584-590, 1985.
8. Gjedde A, Reith J, Dyve S, et al. Dopa decarboxylase activity of the living human brain. Proc Natl Acad Sci U S A, 88: 2721-2725, 1991.
9. 18F]fluoro-DOPA and positron emission tomography: error analysis and application to normal subjects. J Cereb Blood Flow Metab, 13: 43-56, 1993.
10. Arahata Y, Hirayama M, Ieda T, et al. Parieto-occipital glucose hypometabolism in Parkinson's disease with autonomic failure. J Neurol Sci, 163: 119-126, 1999.
11. Imamura T, Ishii K, Sasaki M, et al. Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease: a comparative study using positron emmision tomography. Neurosci Lett, 235: 49-52, 1997.
12. Ishii K, Imamura T, Sasaki M, et al. Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease. Neurology, 51: 125-130, 1998.
13. Higuchi M, Tashiro M, Arai H, et al. Glucose hypometabolism and neuropathological correlates in brains of dementia with Lewy bodies. Exp Neurol, 162: 247-256, 2000.
14. Cordery RJ, Tyrrell PJ, Lantos PL, Rossor MN. Dementia with Lewy bodies studied with positron emission tomography. Arch Neurol, 58: 505-508, 2000.
15. McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology, 47: 1113-1124, 1996.
16. Yu DC, Huang SC, Barrio JR, Phelps ME. The assessment of the non-equilibrium effect in the 'Patlak analysis' of Fdopa PET studies. Phys Med Biol, 40: 1243-1254, 1995.
17. 18F]fluoro-DOPA in human positron emission tomographic studies. J Cereb Blood Flow Metab, 11: 898-913, 1991.
18. Wahl L, Nahmias C. Modeling of fluorine-18-6-fluoro-L-Dopa in humans. J Nucl Med, 37: 432-437, 1996.
19. Logan J, Fowler JS, Volkow ND, Wang GJ, Ding YS, Alexoff DL. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab, 16: 834-840, 1996.
20. 11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab, 10: 740-747, 1990.
21. Huang SC, Stout DB, Yee RE, Satyamurthy N, Barrio JR. Distribution volume of radiolabeled large neutral amino acids in brain tissue. J Cereb Blood Flow Metab, 18: 1288-1293, 1998.