High impact of an expanded restriction fragment length polymorphism assay on detection of ganciclovir-resistant UL97 mutants of human cytomegalovirus [2]

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 1, 2003, Pages 442-443

  Eckle, Tobias ^a   Jahn, Gerhard ^a   Hamprecht, Klaus ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR;

ANTIBIOTIC RESISTANCE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM MUTANT; CODON; GENETIC SCREENING; HUMAN CYTOMEGALOVIRUS; LETTER; MUTATIONAL ANALYSIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RESTRICTION SITE; TECHNIQUE;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CODON; CYTOMEGALOVIRUS; DRUG RESISTANCE, VIRAL; GANCICLOVIR; HUMANS; POINT MUTATION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 0037226357     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.1.442-443.2003     Document Type: Letter

References (6)

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2. Eckle, T., L. Prix, G. Jahn, T. Klingebiel, R. Handgretinger, B. Selle, and K. Hamprecht. 2000. Drug-resistant human cytomegalovirus infection in children after allogeneic stem cell transplantation may have different clinical outcomes. Blood 96:3286-3289.
3. Emery, V. C. 2001. Progress in understanding cytomegalovirus drug resistance. J. Clin. Virol. 21:223-228.
4. Gilbert, C., J. Roy, R. Belanger, R. Delage, C. Beliveau, C. Demers, and G. Boivin. 2001. Lack of emergence of cytomegalovirus UL97 mutations conferring ganciclovir (GCV) resistance following preemptive GCV therapy in allogeneic stem cell transplant recipients. Antimicrob. Agents Chemother. 45:3669-3671.
5. Limaye, A. P., G. Raghu, D. M. Koelle, J. Ferrenberg, M. L. Huang, and M. Boeckh. 2002. High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy. J. Infect. Dis. 185:20-27.
6. Prix, L., K. Hamprecht, B. Holzhüter, R. Handgretinger, T. Klingebiel, and G. Jahn. 1999. Comprehensive restriction analysis of the UL97 region allows early detection of ganciclovir-resistant human cytomegalovirus in an immunocompromised child. J. Infect. Dis. 180:491-495.