A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery

American Journal of Surgery

Volumn 185, Issue 1, 2003, Pages 45-49

  Woodfield, John C ^a   Van Rij, Andre M ^a   Pettigrew, Ross A ^a   Van der Linden, Antje J ^a   Solomon, Clive ^a   Bolt, Donna ^b  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b NONE

Author keywords

Cefotaxime; Ceftriaxone; Chest infection; Prophylaxis; Staphylococcus aureus; Urinary infection; Wound infection

Indexed keywords

ANTIBIOTIC AGENT; CEFOTAXIME; CEFTRIAXONE;

ABDOMINAL SURGERY; ADULT; AGED; ANESTHESIA INDUCTION; APPENDECTOMY; ARTICLE; CLINICAL TRIAL; COLORECTAL SURGERY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; INFECTION PREVENTION; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STAPHYLOCOCCUS AUREUS; THORAX DISEASE; URINARY TRACT INFECTION; WOUND INFECTION;

ABDOMEN; ADULT; AGED; ANTIBIOTIC PROPHYLAXIS; CEFOTAXIME; CEFTRIAXONE; DIGESTIVE SYSTEM DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; PROBABILITY; PROSPECTIVE STUDIES; REFERENCE VALUES; SURGICAL WOUND INFECTION; TREATMENT OUTCOME;

EID: 0037225548     PISSN: 00029610     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9610(02)01125-X     Document Type: Article

References (35)

1. Burke J.F. The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery. 50:1961;161-168.
2. Polk H.C., Trachtenberg L., Finn M.P. Antibiotic activity in surgical incisions. The basis of prophylaxis in selected operations. JAMA. 244:1980;1353-1354.
3. Polk H.C., Trachtenberg L., George C.D. A randomized, double-blind trial of single dose piperacillin verses multiple dose cefoxitin in alimentary tract operations. Am J Surg. 152:1986;517-521.
4. Benigno B.B., Ford L.C., Ledger W.J., et al. A double-blind, controlled comparison of piperacillin and cefoxitin in the prevention of postoperative infection in patients undergoing cesarean section. Surg Gynecol Obstet. 162:1986;1-7.
5. Chambers S.T. Which cephalosporin? NZ Med J. 105:1992;498-500.
6. Chau PY, Ng WWS. Ceftriaxone in-vitro activity against important clinical isolates in comparison with other new cephalosporins. Symposium: Progress in therapy of bacterial infections. A new cephalosporin: ceftriaxone. Excerpta Medica Asia Pacific Congress series No. 19.
7. Jones R.N., Barry A.L., Aldridge K.E., Gerlach E.H. Comparative antimicrobial activity of aminothiazolyl methoxyimino cephalosporins against anaerobic bacteria, including 100 cefoxitin-resistant isolates. Diagn Microbiol Infect Dis. 8:1987;157-163.
8. Stoekel K., McNamara P.J., Brandt R., et al. The effects of concentration dependent plasma protein binding on the pharmacokinetics of ceftriaxone, a new parenteral cephalosporin. Clin Pharmacol Ther. 29:1981;650.
9. Mazzei T, Periti P. Comparative evaluation of ceftriaxone tissue penetration. Update on antibiotic prophylaxis in surgery. 33rd World Congress of Surgery, Toronto, Canada, International Society of Surgery, 17-21.
10. Esmieu F., Guilbert J., Rosenkilde H.C., et al. Pharmacokinetics of cefotaxime in normal human volunteers. J Antimicrob Chemother. 6:1980;A83-92.
11. Jones R.N., Erwin M.E., Bale M. New insights into the activity of third generation cephalosporins against pneumonia causing bacteria. Diagn Microbiol Infect Dis. 15:1992;73-80.
12. Burman L.G., Ostensson R. Time and media saving testing and identification of microorganisms by multipoint innoculation on undivided agar plates. J Clin Microbiol. 8:1978;219-227.
13. Ballows A, Haasler WJ. Manual of clinical microbiology. 5th ed. ASM Press, 1991.
14. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests - fourth edition (approved standard). NCCLS document; M7-A2; v10, no. 8. Villanova, PA: NCCLS, 1990.
15. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests - fourth edition (approved standard). NCCLS document; M2-A6; v10, no. 7. Villanova, PA: NCCLS, 1990.
16. Wittmann D.H., Condon R.E. Prophylaxis of postoperative infections. Infection. 19:(suppl 6):1991;S337-344.
17. Lumley J.W., Siu S.K., Pillay S.P., et al. Single dose ceftriaxone as prophylaxis for sepsis in colorectal surgery. Aust NZ J Surg. 62:1992;292-296.
18. Lang S.D.R., Morris A.J., Charlesworth P.M. Prophylaxis in appendicectomy with cefoxitin or ceftriaxone. NZ Med J. 101:1988;781-783.
19. Stratton C.W., Kernodle D.S., Eades S.C., Weeks L.S. Evaluation of cefotaxime alone and in combination with desacetylcefotaxime against strains of Staphylococcus aureus that produce variants of Staphylococcal β-lactamase. Diagn Microbiol Infect Dis. 12:1989;57-65.
20. Canawati H.N. A reassessment of the activity of the third generation cephalosporins against anaerobes and Staphylococcus aureus. Am J Surg. 164:(suppl 4):1992;A24-27.
21. Marshall J.C., Christou N.V., Meakins J.L. The gastrointestinal tract. The "undrained abscess" of multiple organ failure. Ann Surg. 218:1993;111-119.
22. Morris W.T. Effectiveness of ceftriaxone versus cefoxitin in reducing chest and wound infections after upper abdominal operation. Am J Surg. 167:1994;391-395.
23. de la Hunt M., O'Malley V., Reddy P., Karran S.J. Effective prophylaxis in biliary surgery using single dose ceftriaxone. Chemoteropia. 4:(suppl 2):1984;729-730.
24. Morris W.T. Ceftriaxone is more effective than gentamicin plus metronidazole prophylaxis in reducing wound and urinary tract infections after bowel operations. Dis Colon Rectum. 36:1993;826-833.
25. Yamakawa T., Patin S., Sobel S., Morgenstern L. Healing of colonic anastomoses following resection for experimental "diverticulitis" Arch Surg. 103:1971;17-20.
26. Irvin T.T. Collagen metabolism in infected colonic anastomoses. Surg Gynecol Obstet. 143:1976;220-223.
27. Gutman M., Klausner J.M., Lelcuk S. Fecal peritonitis-the effect on anastomotic healing. Eur Surg Res. 25:1993;366-369.
28. Irvin T.T., Goligher J.C. Aetiology of disruption of intestinal anastomoses. Br J Surg. 60:1973;461-464.
29. Peoples J.B., Vilk D.R., Maguire J.P., et al. Reassessment of primary resection of the perforated segment for severe colonic diverticulitis. Am J Surg. 159:1990;291-293.
30. Wittmann D.H. Antibiotic concentrations in tissue fluid during the vulnerable period as a rational basis for prophylaxis of postoperative infections: focus on infections after operations of the colon, biliary tree and bone. Ishigami J. Recent advances in chemotherapy, antimicrobial section 1. 1985;189-192 University of Tokyo Press, Tokyo.
31. Shinagawa N. Comparative pharmacokinetics of ceftriaxone, cefmetazole and moxalactam during abdominal surgery. J Chemother 1988;(suppl 4):524-5.
32. Brook I. Enhancement of growth of aerobic and facultative bacteria in mixed infections with bacteroides species. Infect Immun. 50:1985;929-931.
33. Rowe-Jones D.C., Peel A.L.G., Kingston R.D., et al. Single dose cefotaxime plus metronidazole versus three dose cefuroxime plus metronidazole as prophylaxis against wound infection in colorectal surgery multicentre prospective randomized study . BMJ. 300:1990;18-22.
34. McDonald M., Grabsch E., Marshall C., Forbes A. Single versus multiple dose antimicrobial prophylaxis for major surgery a systematic review . Aust NZ J Surg. 68:1998;388-396.
35. McDonald P.J., Sanders R., Turnidge J., et al. Optimal duration of cefotaxime prophylaxis in abdominal and vaginal hysterectomy. Drugs. 35:(suppl 2):1988;216-220.