Dipyridamole, cold pressor test, and demonstration of endothelial dysfunction: A PET study of myocardial perfusion in diabetes

Journal of Nuclear Medicine

Volumn 44, Issue 1, 2003, Pages 19-23

  Kjaer, Andreas ^a,c   Meyer, Christian ^a   Nielsen, Flemming S ^b   Parving, Hans Henrik ^b   Hesse, Birger ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b STENO DIABETES CENTER   (Denmark)

^c Department of Clinical Physiology ^*  (Denmark)

Author keywords

Cold pressor test; Diabetes; Endothelial dysfunction; Myocardial perfusion; PET

Indexed keywords

AMMONIA; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPYRIDAMOLE; HEMOGLOBIN A1C; N(G) METHYLARGININE; NITROGEN 13; PERINDOPRILAT; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLD PRESSOR TEST; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HEART RATE; HUMAN; INTERMETHOD COMPARISON; NON INSULIN DEPENDENT DIABETES MELLITUS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; VASCULAR ENDOTHELIUM; VASOMOTOR REFLEX;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; COLD; CORONARY CIRCULATION; CORONARY DISEASE; DIABETES MELLITUS, TYPE 2; DIPYRIDAMOLE; ENDOTHELIUM, VASCULAR; HEART; INDOLES; NITROGEN RADIOISOTOPES; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, EMISSION-COMPUTED; VASODILATOR AGENTS;

EID: 0037224927     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Watts GF, O'Brien SF, Silvester W, Millar JA. Impaired endothelium-dependent and independent dilatation of forearm resistance arteries in men with diet-treated non-insulin-dependent diabetes: role of dyslipidaemia. Clin Sci (Lond). 1996;91:567-573.
2. McVeigh GE, Brennan GM, Johnston GD, et al. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 1992;35:771-776.
3. Williams SB, Cusco JA, Roddy MA, Johnstone MT, Creager MA. Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. J Am Coll Cardiol. 1996;27:567-574.
4. Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction: implications for the syndrome of insulin resistance. J Clin Invest. 1996;97:2601-2610.
5. Zeiher AM, Drexler H, Wollschlaeger H, Saurbier B, Just H. Coronary vasomotion in response to sympathetic stimulation in humans: importance of the functional integrity of the endothelium. J Am Coll Cardiol. 1989;14:1181-1190.
6. Beanlands RS, Muzik O, Melon P, et al. Noninvasive quantification of regional myocardial flow reserve in patients with coronary atherosclerosis using nitrogen-13 ammonia positron emission tomography: determination of extent of altered vascular reactivity. J Am Coll Cardiol. 1995;26:1465-1475.
7. Gould KL, Schelbert HR, Phelps ME, Hoffman EJ. Noninvasive assessment of coronary stenoses with myocardial perfusion imaging during pharmacologic coronary vasodilatation. V. Detection of 47 percent diameter coronary stenosis with intravenous nitrogen-13 ammonia and emission-computed tomography in intact dogs. Am J Cardiol. 1979;43:200-208.
8. 13N-ammonia and reoriented dynamic positron emission tomographic imaging. Circulation. 1992;86:1004-1017.
9. Yokoyama I, Momomura S, Ohtake T, Yonekura K, Nishikawa J, Sasaki Y, Omata M. Reduced myocardial flow reserve in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol. 1997;30:1472-1477.
10. Yokoyama I, Ohtake T, Momomura S, et al. Hyperglycemia rather than insulin resistance is related to reduced coronary flow reserve in NIDDM. Diabetes. 1998;47:119-124.
11. Williams SB, Goldfine AB, Timimi FK, et al. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation. 1998;97:1695-1701.
12. O'Driscoll G, Green D, Maiorana A, Stanton K, Colreavy F, Taylor R. Improvement in endothelial function by angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol. 1999;33:1506-1511.
13. Smits P, Williams SB, Lipson DE, Banitt P, Rongen GA, Creager MA. Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans. Circulation. 1995;92:2135-2141.
14. Lupi A, Buffon A, Finocchiaro ML, Conti E, Maseri A, Crea F. Mechanisms of adenosine-induced epicardial coronary artery dilatation. Eur Heart J. 1997;18:614-617.
15. Nitenberg A, Ledoux S, Valensi P, Sachs R, Attali JR, Antony I. Impairment of coronary microvascular dilation in response to cold pressor-induced sympathetic stimulation in type 2 diabetic patients with abnormal stress thallium imaging. Diabetes. 2001;50:1180-1185.
16. Dubois-Rande JL, Dupouy P, Aptecar E, et al. Comparison of the effects of exercise and cold pressor test on the vasomotor response of normal and atherosclerotic coronary arteries and their relation to the flow-mediated mechanism. Am J Cardiol. 1995;76:467-473.
17. Saab PG, Llabre MM, Hurwitz BE, et al. The cold pressor test: vascular and myocardial response patterns and their stability. Psychophysiology. 1993;30:366-373.