Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit

Hepatology

Volumn 37, Issue 1, 2003, Pages 96-106

  Nieto, Natalia ^a   Marí, Montserrat ^a   Cederbaum, Arthur I ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALLYL SULFIDE; ARACHIDONIC ACID; CATALASE; CYTOCHROME P450 2E1; CYTOCHROME P450 INHIBITOR; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; IRON; LUCIFERASE; MENADIONE; MESSENGER RNA; PYRAZOLE;

ANIMAL CELL; ARTICLE; BIOASSAY; CELL STRAIN HEPG2; CONTROLLED STUDY; DELETION MUTANT; DNA FLANKING REGION; DNA SEQUENCE; DNA VECTOR; DOSE RESPONSE; ENZYME ACTIVE SITE; ENZYME INDUCTION; ENZYME SUBUNIT; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT;

EID: 0037222397     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2003.50003     Document Type: Article

References (48)

1. DeLeve L, Kaplowitz N. Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther 1991;52:287-305.
2. Hutter DE, Till BG, Greene JJ. Redox state changes in density-dependent regulation of proliferation. Exp Cell Res 1997;232:435-438.
3. Lu SC. Up-regulation of hepatic glutathione synthesis. Semin Liver Dis 1998;18:331-343.
4. Lu SC. Regulation of hepatic glutathione synthesis: Current concepts and controversies. FASEB J 1999;13:1169-1183.
5. Meister A. Glutathione. In: Arias IM, Jakoby WB, Popper H, Schachter D, Shafritz DA, eds. The Liver: Biology and Pathobiology. 2nd Ed. New York: Raven, 1998:401-417.
6. Suthanthiran M, Anderson ME, Sharma VK, Meister A. Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proc Natl Acad Sci U S A 1990;87:3343-3347.
7. Fernandez-Checa J, Lu SC, Ookhtens M, DeLeve L, Runnegar M, Yoshida H, Saiki H, et al. The regulation of hepatic glutathione. In: Tavoloni N, Berk PD, eds. Hepatic Anion Transport and Bile Secretion: Physiology and Pathophysiology. New York: Marcel Dekker, 1992:363-395.
8. Ookhtens M, Kaplowitz N. Role of the liver in interorgan homeostasis of glutathione and cysteine. Semin Liver Dis 1998;18:313-329.
9. Gipp JJ, Bailey HH, Mulcahy RT. Cloning and sequence of the cDNA for the light subunit of human liver γ-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues. Biochem Biophys Res Commun 1995;206:584-589.
10. Gipp JJ, Chang C, Mulcahy RT. Cloning and nucleotide sequence of a full-length cDNA for human liver γ-glutamylcysteine synthetase. Biochem Biophys Res Commun 1992;185:29-35.
11. Huang C, Anderson ME, Meister A. Amino acid sequence and function of the light subunit of rat kidney γ-glutamylcysteine synthetase. J Biol Chem 1993;268:20578-20583.
12. Yan N, Meister A. Amino acid sequence of rat kidney γ-glutamylcysteine synthetase. J Biol Chem 1990;265:1588-1593.
13. Seelig GF, Simondsen RP, Meister A. Reversible dissociation of γ-glutamylcysteine synthetase into two subunits. J Biol Chem 1984;259:9345-9347.
14. Huang CS, Moore WR, Meister A. On the active thiol site of γ-glutamylcysteine synthetase: Relationship to catalysis, inhibition, and regulation. Proc Natl Acad Sci U S A 1988;85:2464-2468.
15. Huang C, Chang L, Anderson ME, Meister A. Catalytic and regulatory properties of the heavy subunit of rat kidney γ-glutamylcysteine synthetase. J Biol Chem 1993;268:19675-19680.
16. Misra I, Griffith OW. Expression and purification of human γ-glutamylcysteine synthetase. Protein Exp Purif 1998;13:268-276.
17. Grant CM, Maclver FH, Dawes IW. Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide γ-glutamylcysteine. Mol Biol Cell 1997;8:1699-1707.
18. Huang CS, He W, Meister A, Anderson ME. Amino acid sequence of rat kidney glutathione synthetase. Proc Natl Acad Sci U S A 1995;92:1232-1236.
19. Friling RS, Bensimon A, Tichauer Y, Daniel V. Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile responsive element. Proc Natl Acad Sci U S A 1991;87: 6258-6262.
20. Mulcahy RT, Gipp JJ. Identification of a putative antioxidant response element in the 5′-flanking region of the human gamma-glutamylcysteine synthetase heavy subunit gene. Biochem Biophys Res Commun 1995;209: 227-233.
21. Mulcahy RT, Wartman MA, Bailey HH, Gipp JJ. Constitutive and betanaphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence. J Biol Chem 1997;272:7445-7454.
22. Rushmore TH, Morton MR, Pickett CB. The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem 1991;266: 11632-11639.
23. Yao KS, Godwin AK, Johnson WW, Ozols RF, O'Dwyer PJ, Hamilton TC. Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines. Cancer Res 1995;55:4367-4374.
24. Koop DR. Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J 1992;6:724-730.
25. Ekstrom G, Ingelman-Sundberg M. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1). Biochem Pharmacol 1989;38: 1313-1319.
26. Gorsky LD, Koop DR, Coon MJ. On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450. Products of oxygen reduction. J Biol Chem 1984;259:6812-6817.
27. Vaz AD, Roberts ES, Coon MJ. Reductive beta-scission of the hydroperoxides of fatty acids and xenobiotics: Role of alcohol-inducible cytochrome P-450. Proc Natl Acad Sci U S A 1990;87:5499-5503.
28. Mari M, Cederbaum AI. CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of γ-glutamylcysteine synthetase. J Biol Chem 2000;275:15563-15571.
29. Tsukamoto H, Lu SC. Current concepts in the pathogenesis of alcoholic liver disease. FASEB J 2001;15:1335-1349.
30. Chen Q, Cederbaum AI. Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in HepG2 cells. Mol Pharmacol 1998;53:638-648.
31. Wu D, Cederbaum AI. Induction of liver cytochrome P4502E1 by pyrazole and 4-methylpyrazole in neonatal rats. J Pharmacol Exp Ther 1993; 264:1468-1473.
32. Nieto N, Friedman SL, Greenwel P, Cederbaum AI. CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells. Hepatology 1999;30:987-996.
33. Franklin CC, Krejsa CM, Pierce RH, White CC, Fausto N, Kavanagh TJ. Caspase-3-dependent cleavage of the glutamate-L-cysteine ligase catalytic subunit during apoptotic cell death. Am J Pathol 2002;160:1887-1894.
34. Thompson SA, White CC, Krejsa CM, Diaz D, Woods JS, Eaton DL, Kavanagh TJ. Induction of glutamate-cysteine ligase (γ-glutamylcysteine synthetase) in the brains of adult female mice subchronically exposed to methylmercury. Toxicol Lett 1999;110:1-9.
35. Bai J, Cederbaum AI. Adenovirus-mediated expression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P450 2E1-dependent toxicity in HepG2 cells. J Biol Chem 2001;274: 26217-26224.
36. Tietze F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal Biochem 1969;27:502-522.
37. Tsukamoto H, Matsuoka M, French S. Experimental models of hepatic fibrosis: A review. Semin Liver Dis 1990;10:56-65.
38. Niemela O. Distribution of ethanol-induced protein adducts in vivo: Relationship to tissue injury. Free Radic Biol Med 2001;31:1533-1538.
39. Caro A, Cederbaum AI. Synergistic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1. Mol Pharmacol 2001;60:742-752.
40. Sakurai K, Cederbaum AI. Oxidative stress and cytotoxicity induced by ferric nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1. Mol Pharmacol 1998;54:1024-1035.
41. Mari M, Cederbaum AI. Induction of catalase, alpha, and microsomal glutathione S-transferase in CYP2E1 overexpressing HepG2 cells and protection against short-term oxidative stress. Hepatology 2001;33:652-661.
42. De La M Hall P, Lieber CS, DeCarli LM, French SW, Lindros KO, Jarvelainen H, Bode C, et al. Models of alcoholic liver disease in rodents: A critical evaluation. Alcohol Clin Exp Res 2001;25:254S-261S.
43. French SW, Morimoto M, Reitz RC, Koop D, Klopfenstein B, Estes K, Clot P, et al. Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats. J Nutr 1997;127:907S-911S.
44. Favreau LV, Pickett CB. Transcriptional regulation of the rat NAD(P)H: Quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants. J Biol Chem 1991;266:4556-4561.
45. Tsuji Y, Ayaki H, Whitman SP, Morrow CS, Torti SV, Torti FM. Coordinate transcriptional and translational regulation of ferritin in response to oxidative stress. Mol Cell Biol 2000;20:5818-5827.
46. Kensler TW. Chemoprevention by inducers of carcinogen detoxification enzymes. Environ Health Perspect 1997;105:965-970.
47. Zhu M, Fahl WE. Functional characterization of transcription regulators that interact with the electrophile response element. Biochem Biophys Res Commun 2001;289:212-219.
48. Lu SC, Huang ZZ, Yang JM, Tsukamoto H. Effect of ethanol and high fat feeding on hepatic γ-GCS subunit expression in the rat. Hepatology 1999;30:209-214.