Heparin-induced thrombocytopenia with associated thrombosis in children after the Fontan operation: Report of two cases

Texas Heart Institute Journal

Volumn 30, Issue 1, 2003, Pages 58-61

  Porcelli, Rosalia ^a   Moskowitz̈, Bonnie C ^a   Cetta, Frank ^a   Graham, Lynn C ^a   Godwin, John E ^a   Eidem, Benjamin W ^a   Prechel, M Margaret ^a   Walenga, Jeanine M ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Anticoagulants adverse effects; Heparin adverse effects; Thrombocytopenia chemically induced diagnosis prevention control; Thrombosis etiology prevention control

Indexed keywords

HEPARIN;

AORTA STENOSIS; ARTICLE; CASE REPORT; CLINICAL FEATURE; CONGENITAL HEART DISEASE; DIAGNOSTIC TEST; DISEASE COURSE; DISSEMINATED INTRAVASCULAR CLOTTING; FONTAN PROCEDURE; HOSPITAL DISCHARGE; HUMAN; MALE; MORBIDITY; MORTALITY; POSTOPERATIVE CARE; PRESCHOOL CHILD; SURGICAL MORTALITY; SURGICAL TECHNIQUE; THROMBECTOMY; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; THROMBOSIS;

ANTICOAGULANTS; CHILD, PRESCHOOL; FONTAN PROCEDURE; HEART DEFECTS, CONGENITAL; HEPARIN; HUMANS; MALE; POSTOPERATIVE COMPLICATIONS; THROMBOCYTOPENIA; THROMBOSIS;

EID: 0037222232     PISSN: 07302347     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Wallis DE, Workman DL, Lewis BE, Steen L, Pifarre R, Moran JF. Failure of early heparin cessation as treatment for heparin-induced thrombocytopenia. Am J Med 1999;106(6):629-35.
2. Warkentin TE, Kelton JG. A 14-year study of heparin-induced thrombocytopenia. Am J Med 1996;101:502-7.
3. Brieger DB, Mak KH, Kottke-Marchant K, Topol EJ. Heparin-induced thrombocytopenia. J Am Coll Cardiol 1998;31:1449-59.
4. Silver D, Kapsch DN, Tsoi EK. Heparin-induced thrombocytopenia, thrombosis, and hemorrhage. Ann Surg 1983;198:301-6.
5. Laster J, Cikrit D, Walker N, Silver D. The heparin-induced thrombocytopenia syndrome: an update. Surgery 1987;102:763-70.
6. Murdoch IA, Beattie RM, Silver DM. Heparin-induced thrombocytopenia in children. Acta Paediatr 1993;82:495-7.
7. Klement D, Rarnmos S, v Kries R, Kirschke W, Kniemeyer HW, Greinacher A. Heparin as a cause of thrombus progression. Heparin-associated thrombocytopenia is an important differential diagnosis in paediatric patients even with normal platelet counts. Eur J Pediatr 1996;155:11-4.
8. Butler TJ, Sodoma LJ, Doski JJ, Cheu HW, Berg ST, Stokes GN, Lancaster KJ. Heparin-associated thrombocytopenia and thrombosis as the cause of a fatal thrombus on extracorporeal membrane oxygenation. J Pediatr Surg 1997;32:768-71.
9. Schiffmann H, Unterhalt M, Harms K, Figulla HR, Volpel H, Greinacher A. Erfolgreiche behundlung einer heparin-induzierten thrombozytopenie typ II im kindesalter mit rekombinantem hirudin. Monat Kinderheilkd 1997;145:606-12.
10. Amiral J, Bridey F, Dreyfus M, Vissoc AM, Fressinaud E, Wolf M, Meyer D. Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb Haemost 1992;68:95-6.
11. Chong BH, Fawaz I, Chesterman CN, Berndt MC. Heparin-induced thrombocytopenia: mechanism of interaction of the heparin-dependent antibody with platelets. Br J Haematol 1989;73:235-40.
12. Anderson GP. Insights into heparin-induced thrombocytopenia. Br J Haematol 1992;80:504-8.
13. Anderson GP, van de Winkel JG, Anderson CL. Anti-GP IIb/IIIa (CD41) monoclonal antibody-induced platelet activation requires Fc receptor-dependent cell-cell interaction. Br J Haematol 1991;79:75-83.
14. Jeske WP, Walenga JM, Szatkowski E, Ero M, Herbert JM, Haas S, Bakhos M. Effect of glycoprotein IIb/IIIa antagonists on the HIT serum induced activation of platelets. Thromb Res 1997;88:271-81.
15. Herbert JM, Savi P, Jeske WP, Walenga JM. Effect of SR121566A, a potent GP IIb-IIIa antagonist, on the HIT serum/heparin-induced platelet mediated activation of human endothelial cells. Thromb Haemost 1998;80:326-31.
16. Kelton JG. Heparin-induced thrombocytopenia. Haemostasis 1986;16:173-86.
17. Sheridan D, Carter C, Kelton JG. A diagnostic test for heparin-induced thrombocytopenia. Blood 1986;67:27-30.
18. Walenga JM, Jeske WP, Fasanella AR, Wood JJ, Bakhos M. Laboratory tests for the diagnosis of heparin-induced thrombocycopenia. Semin Thromb Hemost 1999;25(Suppl 1):43-9.
19. Arepally G, Reynolds C, Tomaski A, Amiral J, Jawad A, Poncz M, Cines DB. Comparison of PF4/heparin ELISA assay with the 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia. Am J Clin Pathol 1995;104:648-54.
20. Walenga JM, Jeske WP, Wood JJ, Ahmad S, Lewis BE, Bakhos M. Laboratory tests for heparin-induced thrombocytopenia: a multicenter study. Semin Hematol 1999;36(1 Suppl 1):22-8.
21. Singer RL, Mannion JD, Bauer TL, Armenti FR, Edie RN. Complications from heparin-induced thrombocytopenia in patients undergoing cardiopulmonary bypass. Chest 1993;104:1436-40.
22. Makhoul RG, Greenberg CS, McCann RL. Heparin-associated thrombocytopenia and thombosis: a serious clinical problem and potential solution. J Vasc Surg 1986;4:522-8.