Subunit-specific modulation of KCNQ potassium channels by Src tyrosine kinase

Journal of Neuroscience

Volumn 23, Issue 1, 2003, Pages 84-95

  Gamper, Nikita ^a   Stockand, James D ^a   Shapiro, Mark S ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Ion channel modulation; K+ channel; KCNQ channel; M current; Muscarinic receptor; Patch clamp; Signaling; Src; Tyrosine kinase

Indexed keywords

ERBSTATIN; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; POTASSIUM CHANNEL; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; VANADATE SODIUM;

ANIMAL CELL; ARTICLE; CELL KINETICS; CHO CELL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SYMPATHETIC NERVE;

EID: 0037220977     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-01-00084.2003     Document Type: Article

References (53)

1. Abram CL, Courtneidge SA (2000) Src family tyrosine kinases and growth factor signaling. Exp Cell Res 254:1-13.
2. Al-Khalili O, Duke BJ, Zeltwanger S, Eaton DC, Spier B, Stockand JD (2001) Cloning of the proto-oncogene c-src from rat testis. DNA Sequence 12:425-429.
3. Barbacid M (1993) Nerve growth factor: A tale of two receptors. Oncogene 8:2033-2042.
4. Bernheim L, Beech DJ, Hille B (1991) A diffusible second messenger mediates one of the pathways coupling receptors to calcium channels in rat sympathetic neurons. Neuron 6:859-867.
5. Biervert C, Schroeder BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ, Steinlein OK (1998) A potassium channel mutation in neonatal human epilepsy. Science 279:403-406.
6. + current in a vertebrate neurone. Nature 283:673-676.
7. + current by Src tyrosine kinase. J Biol Chem 277:13673-13681.
8. Cayabyab FS, Khanna R, Jones OT, Schlichter LC (2000) Suppression of the rat microglia Kv1.3 current by src-family tyrosine kinases and oxygen/glucose deprivation. Eur J Neurosci 12:1949-1960.
9. Charlier C, Singh NA, Ryan SG, Lewis TB, Reus BE, Leach RJ, Leppert M (1998) A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat Genet 18:53-55.
10. Constanti A, Brown DA (1981) M-Currents in voltage-clamped mammalian sympathetic neurones. Neurosci Lett 24:289-294.
11. Cooper EC, Aldape KD, Abosch A, Barbaro NM, Berger MS, Peacock WS, Jan YN, Jan LY (2000) Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy. Proc Natl Acad Sci USA 97:4914-4919.
12. Coucke PJ, Hauwe PV, Kelley PM, Kunst H, Schatteman I, Velzen DV, Meyers J, Ensink RJ, Verstreken M, Declau F, Marres H, Kastury K, Bhasin S, McGuirt WT, Smith RJ, Cremers CW, Heyning PV, Willems PJ, Smith SD, Camp GV (1999) Mutations in the KCNQ4 gene are responsible for autosomal dominant deafness in four DFNA2 families. Hum Mol Genet 8:1321-1328.
13. Diverse-Pierluissi M, Remmers AE, Neubig RR, Dunlap K (1997) Novel form of crosstalk between G protein and tyrosine kinase pathways. Proc Natl Acad Sci USA 94:5417-5421.
14. Fadool DA, Holmes TC, Berman K, Dagan D, Levitan IB (1997) Tyrosine phosphorylation modulates current amplitude and kinetics of a neuronal voltage-gated potassium channel. J Neurophysiol 78:1563-1573.
15. Felsch JS, Cachero TG, Peralta EG (1998) Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor. Proc Natl Acad Sci USA 95:5051-5056.
16. Hille B (2001) Ion Channels of Excitable Membranes, Ed 3. Sunderland, MA: Sinauer.
17. Holmes TC, Fadool DA, Levitan IB (1996a) Tyrosine phosphorylation of the Kv1.3 potassium channel. J Neurosci 16:1581-1590.
18. Holmes TC, Fadool DA, Ren R, Levitan IB (1996b) Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain. Science 274:2089-2091.
19. Holt JR, Corey DP (1999) Ion channel defects in hereditary hearing loss. Neuron 22:217-219.
20. Huang XY, Morielli AD, Peralta EG (1993) Tyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled ml muscarinic acetylcholine receptor. Cell 75:1145-1156.
21. Hubbard SR, Till JH (2000) Protein tyrosine kinase structure and function. Annu Rev Biochem 69:373-398.
22. i-coupled receptors. Biochem Biophys Res Commun 244:5-10.
23. Jentsch TJ (2000) Neuronal KCNQ potassium channels: Physiology and role in disease. Nat Rev Neurosci 1:21-30.
24. + channel from rat brain. Brain Res Mol Brain Res 80:269-278.
25. + channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway. Proc Natl Acad Sci USA 97:4333-4338.
26. Kubisch C, Schroeder BC, Friedrich T, Lutjohann B, El-Amraoui A, Marlin S, Petit C, Jentsch TJ (1999) KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 96:437-446.
27. Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K (2000) Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity. J Biol Chem 275:22395-22400.
28. + channel in the presence of Src tyrosine kinase. J Biol Chem 275:30683-30689.
29. Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Krueger KM, Touhara K, Lefkowitz RJ (1997) G-protein-coupled receptors and their regulation: Activation of the MAP kinase signaling pathway by G-protein-coupled receptors. Adv Second Messenger Phosphoprotein Res 31:263-277.
30. Luttrell LM, Daaka Y, Lefkowitz RJ (1999) Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol 11:177-183.
31. Ma YC, Huang XY (2002) Novel regulation and function of Src tyrosine kinase. Cell Mol Life Sci 59:456-462.
32. Miller WE, Maudsley S, Ahn S, Khan KD, Luttrell LM, Lefkowitz RJ (2000) beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC: Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. J Biol Chem 275:11312-11319.
33. Nitabach MN, Llamas DA, Araneda RC, Intile JL, Thompson IJ, Zhou YI, Holmes TC (2001) A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors. Proc Natl Acad Sci USA 98:705-710.
34. Nitabach MN, Llamas DA, Thompson IJ, Collins KA, Holmes TC (2002) Phosphorylation-dependent and phosphorylation-independent modes of modulation of shaker family voltage-gated potassium channels by SRC family protein tyrosine kinases. J Neurosci 22:7913-7922.
35. Pierce KL, Luttrell LM, Lefkowitz RJ (2001) New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene 20:1532-1539.
36. Robbins J (2001) KCNQ potassium channels: Physiology, pathophysiology, and pharmacology. Pharmacol Ther 90:1-19.
37. + channels. Br J Pharmacol, in press.
38. Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, Keating MT (1996) Coassembly of K(V)LQT1 and mink (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 384:80-83.
39. Sanna PP, Berton F, Cammalleri M, Tallent MK, Siggins GR, Bloom FE, Francesconi W (2000) A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus. Proc Natl Acad Sci USA 97:8653-8657.
40. Schinder AF, Poo M (2000) The neurotrophin hypothesis for synaptic plasticity. Trends Neurosci 23:639-645.
41. + channels causes epilepsy. Nature 396:687-690.
42. Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ (2000) KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J Biol Chem 275:24089-24095.
43. Selyanko AA, Stansfeld CE, Brown DA (1992) Closure of potassium M-channels by muscarinic acetylcholine-receptor stimulants requires a diffusible messenger. Proc R Soc Lond B Biol Sci 250:119-125.
44. 1 muscarinic acetylcholine receptors. J Physiol (Lond) 522:349-355.
45. Shalaby FY, Levesque PC, Yang WP, Little WA, Conder ML, Jenkins-West T, Blanar MA (1997) Dominant-negative KvLQT1 mutations underlie the LQT1 form of long QT syndrome. Circulation 96:1733-1736.
46. + channels that underlie the neuronal M current. J Neurosci 20:1710-1721.
47. Singh NA, Charlier C, Stauffer D, DuPont BR, Leach RJ, Melis R, Ronen GM, Bjerre I, Quattlebaum T, Murphy JV, McHarg ML, Gagnon D, Rosales TO, Peiffer A, Anderson VE, Leppert M (1998) A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nat Genet 18:25-29.
48. Tatosyan AG, Mizenina OA (2000) Kinases of the Src family: Structure and functions. Biochemistry 65:49-58.
49. Tinel N, Diochot S, Lauritzen I, Barhanin J, Lazdunski M, Borsotto M (2000) M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit. FEBS Lett 480:137-141.
50. Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, Mc-Kinnon D (1998) KCNQ2 and KCNQ3 potassium channel subunits: Molecular correlates of the M-channel. Science 282:1890-1893.
51. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, VanRaay TJ, Shen J, Timothy KW, Vincent GM, de Jager T, Schwartz PJ, Toubin JA, Moss AJ, Atkinson DL, Landes GM, Connors TD, Keating MT (1996) Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 12:17-23.
52. + channels in intestine and pancreas: Lessons from the KCNE1 knockout mouse. Pflügers Arch 443:822-828.
53. Yang WP, Levesque PC, Little WA, Conder ML, Shalaby FY, Blanar MA (1997) KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proc Natl Acad Sci USA 94:4017-4021.