Efficacy of ultraviolet germicidal irradiation of upper-room air in inactivating airborne bacterial spores and mycobacteria in full-scale studies

Atmospheric Environment

Volumn 37, Issue 3, 2003, Pages 405-419

  Xu, Peng ^a   Peccia, Jordan ^a   Fabian, Patricia ^a   Martyny, John W ^b   Fennelly, Kevin P ^c   Hernandez, Mark ^a   Miller, Shelly L ^a  

^a UCB 450   (United States)

^b Tri County Health Department Colorado   (United States)

^c NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Air cleaning; Air disinfection; Bacteria; Bioaerosols; UV lamps

Indexed keywords

ATMOSPHERIC HUMIDITY; BACTERIA; BIOASSAY; CONTINUOUS CELL CULTURE; ENVIRONMENTAL TESTING; STATISTICAL TESTS; ULTRAVIOLET RADIATION; VENTILATION;

ULTRAVIOLET GERMICIDAL IRRADIATION (UVGI);

IRRADIATION;

BACTERIUM; INDOOR AIR; ULTRAVIOLET RADIATION;

AEROSOL; AIR CONDITIONING; AIR SAMPLING; AIRBORNE INFECTION; AMBIENT AIR; ARTICLE; BACILLUS SUBTILIS; BACTERIAL CELL; BACTERIAL COUNT; BACTERIAL SPORE; CONTROLLED STUDY; DEVICE; DISINFECTION; EVALUATION; HUMIDITY; MYCOBACTERIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM PARAFORTUITUM; NONHUMAN; PRIORITY JOURNAL; ULTRAVIOLET IRRADIATION;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MYCOBACTERIUM; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM PARAFORTUITUM;

EID: 0037220814     PISSN: 13522310     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1352-2310(02)00825-7     Document Type: Article

References (37)

1. Black D.R., Harley R.A., Hering S.V., Stolzenburg M.R. A new, portable, real-time ozone monitor. Environmental Science and Technology. 34:2000;303l-3040.
2. Blomquist G., Palmgren U., Strom G. Improved techniques for sampling airborne fungal particles in highly contaminated environments. Scandinavian Journal of Work and Environmental Health. 10:1984;253-258.
3. Blumberg H.M., Watkins D.L., Berschling J.D., Antle A., Moore P., White N., Hunter M., Green B., Ray S.M., McGowan J.E. Jr. Preventing the nosocomial transmission of tuberculosis. Annals of Internal Medicine. 122:1995;658-663.
4. Centers for Disease Control and Prevention, 1994. Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care facilities. Morbidity and Mortality Weekly Report 43(R-13), 1-132.
5. CDC and NIH, Centers for Disease Control and Prevention, National Institutes of Health, 1999. Biosafety in microbiological and biomedical laboratories. Centers for Disease Control and Prevention and National Institutes of Health, DHHS Publication No (CDC) 93-8395, PHS, US Government Printing Office, Washington, DC.
6. Collins F.M. Relative susceptibility of acid-fast and non-acid-fast bacteria to ultraviolet light. Applied Microbiology. 21:1971;41l-413.
7. David H.L. Response of mycobacteria to ultraviolet light radiation. American Review of Respiratory Disease. 180:1973;1175-1185.
8. Dubos R.J., Middlebrook G. Media for Tubercle bacilli. American Review of Tuberculosis. 56:1947;334-345.
9. Fackelmann K. Tuberculosis outbreak. Science News. 153:1998;73-78.
10. Frankel D.H. Tuberculosis falling in LA. Lancet. 345:1995;1565.
11. Goldner, J.L., Moggio, M., Beissinger, S.F., McCollum, D.E., 1980. Ultraviolet light for the control of airborne bacteria in the operating room. In: Kundsin, R.B. (Ed.), Airborne Contagion. New York Academy of Sciences, New York. p. 271-284.
12. Hollander, A., 1942. Abiotic and sublethal effects of ultraviolet radiation in microorganisms. In: Moulton, F.R. (Ed.), Aerobiology, American Association for the Advancement of Science, Vol. 17. The Science Press Printing Co., Lancaster, PA.
13. Hernandez M., Miller S.L., Landfear D.W., Macher J.M. A combined fluorochrome method for quantification of metabolically active and inactive airborne bacteria. Aerosol Science and Technology. 30:1999;145-160.
14. Ikeda R.M., Birkhead J.A., DiFerdinando G.T., Bornstein D.L., Dooley S.W., Kubica G.P., Morse D.L. Nosocomial tuberculosis. an outbreak of a strain resistant to seven drugs Infection Control and Hospital Epidemiology. 16:1995;152-159.
15. Kearns A.M., Barrett A., Marshall C., Freeman R., Magee J.G., Bourke S.J., Steward M. Epidemiology and molecular typing of an outbreak of tuberculosis in a hostel for homeless men. Journal of Clinical Pathology. 53:2000;122-124.
16. Ko G., First M.W., Burge H.A. The characterization of upper-room ultraviolet germicidal irradiation in inactivating airborne microorganisms. Environmental Health Perspectives. 110:2002;95-101.
17. Macher J.M., Alevantis L.E., Chang Y.-L., Liu K.-S. Effect of ultraviolet germicidal lamps on airborne microorganisms in an outpatient waiting room. Applied Occupational and Environmental Hygiene. 7:1992;505-513.
18. Macher J.M., Alevantis L.E., Chang Y.-L., Liu K.-S. Applied Occupational and Environmental Hygiene. 9:1994;462. (letter).
19. Miller S.L., Macher J.M. Evaluation of a methodology for quantifying the effect of room air ultraviolet germicidal irradiation on airborne bacteria. Aerosol Science and Technology. 33:2000;274-295.
20. Miller-Leiden S., Lobascio C., Nazaroff W.W., Macher J.M. Effectiveness of in-room air filtration and dilution ventilation for tuberculosis infection control. Journal of the Air and Waste Management Association. 46:1996;869-882.
21. Morbidity and Mortality Weekly Report, 2002. Tuberculosis morbidity among US-born and foreign-born populations - United States, 2000. Morbidity and Mortality Weekly Report 51(05), 101-104.
22. Nagin D., Pavelchak N., London M., DePersis R.P., Melius J. Control of tuberculosis in the workplace - engineering controls. Occupational Medicine: State of the Art Reviews. 9:1994;609-630.
23. Nardell E.A. Interrupting transmission from patients with unsuspected tuberculosis. a unique role for upper-room ultraviolet air disinfection American Journal of Infection Control. 23:1995;156-164.
24. Nivin B., Nicholas P., Gayer M., Frieden T.R., Fujiwara P.I. A continuing outbreak of multidrug-resistant tuberculosis, with transmission in a hospital nursery. Clinical Infectious Diseases. 26:1998;303-307.
25. Peccia, J., 2000. Ph.D. Thesis, University of Colorado, Boulder.
26. Peccia J., Hernandez M. Photoreactivation in airborne Mycobacteria parafortuitum. Applied and Environmental Microbiology. 67:2001;4225-4232.
27. Peccia, J., Hernandez, M., 2002. UV inactivation rates in airborne Mycobacterium bovis BCG. Applied and Environmental Microbiology, submitted for publication.
28. Peccia J., Werth H., Miller S.L., Hernandez M. The effects of relative humidity on the ultraviolet induced inactivation of airborne bacteria. Aerosol Science and Technology. 35:2001;728-740.
29. Rahn R.O., Xu P., Miller S.L. Dosimetry of room-air germicidal irradiation using spherical actinometry. Photochemistry and Photobiology. 70:1999;314-318.
30. Riley R.L., Wells W.F., Mills C.C., Nyka W., McLean R.L. Air hygiene in tuberculosis. quantitative studies of infectivity and control in a pilot ward American Review of Tuberculosis and Pulmonary Disease. 75:1957;420-431.
31. Riley R.L., Mills C.C., O'Grady F., Sultan L.U., Wittstadt F., Shivpuri D.N. Infectiousness of air from a tuberculosis ward. Ultraviolet irradiation of infected air. comparative infectiousness of different patients American Review of Respiratory Disease. 85:1962;511-525.
32. Riley R.L., Knight M., Middlebrook G. Ultraviolet susceptibility of BCG and virulent tubercle bacilli. American Review of Respiratory Disease. 113:1976;413-418.
33. Ward D.C., Reich E., Goldeberg I.H. Base specificity in the interaction polynuleotides with antibiotic drugs. Science. 149:1965;1259-1263.
34. Wells W.F. Airborne Contagion and Air Hygiene. 1955;Harvard University Press, Cambridge, MA.
35. Wells W.F., Fair G.M. Viability of B. coli exposed to ultraviolet radiation in air. Science. 82:1935;280-281.
36. World Health Organization, 2000. Global tuberculosis control. WHO Report 2000. WHO, Geneva, Switzerland, WHO/CDS/TB/2000.275.
37. Xu, P., Miller, S.L., 1999. Factors influencing effectiveness of ultraviolet germicidal irradiation for inactivating airborne bacteria: Air mixing and ventilation efficiency. In Raw, G., Aizlewood, C., Warren, P. (Eds.), Indoor Air '99: Proceedings of the Eighth International Conference on Indoor Air Quality and Climate. Vol. 2, Edinburgh, Scotland, pp. 393-398.