NS-398, a selective cyclooxygenase-2 blocker, acutely inhibits receptor-mediated contractions of rat aorta: Role of endothelium

European Journal of Pharmacology

Volumn 458, Issue 1-2, 2003, Pages 145-154

  Adeagbo, Ayotunde S O ^a   Patel, Darshana ^a   Iddrissu, Abdallah ^a   Walker, John ^a   Thirumalai, Sridhar ^a   Joshua, Irving G ^a   Schuschke, Dale ^a   Wang, Yang ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Aorta; Cyclooxygenase 2; Endothelium derived; Nitric oxide; NS 398; Rat; Sarcoplasmic reticulum; SERCA (Ca2+ pump)

Indexed keywords

3 (3 FLUOROPHENYL) 5,5 DIMETHYL 4 (4 METHYLSULFONYLPHENYL) 2(5H) FURANONE; ADENOSINE TRIPHOSPHATASE (CALCIUM); CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYCLOPIAZONIC ACID; FLUORIDE SODIUM; L 752860; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NORADRENALIN; POTASSIUM CHLORIDE; SEROTONIN; SODIUM CHLORIDE;

ANIMAL TISSUE; AORTA; AORTA CONSTRICTION; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SARCOPLASMIC RETICULUM; VASCULAR RING;

ANIMALS; AORTA, THORACIC; CALCIUM; CYCLOHEXIMIDE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; INDOLES; ISOENZYMES; MALE; NITROBENZENES; NOREPINEPHRINE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; SEROTONIN; SULFONAMIDES; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0037218963     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)02693-6     Document Type: Article

References (34)

1. Adeagbo A.S.O., Triggle C.R. Mechanism of vascular smooth muscle contraction by sodium fluoride in the isolated aorta of rat and rabbit. J. Pharmacol. Exp. Ther. 258:1991;66-73.
2. Akarasereenont P., Mitchell J.A., Bakhle Y.S., Thiemerman C., Vane J.R. Comparison of the induction of cyclooxygenase and nitric oxide synthase by endotoxin in endothelial cells and macrophages. Eur. J. Pharmacol. 273:1995;121-128.
3. Bateman D.N. NSAIDs: time to re-evaluate gut toxicity [comments]. Lancet. 343:1994;1051-1052.
4. Bishop-Bailey D., Larkin S.W., Warner T.D., Chen G., Mitchell J.A. Characterization of the induction of nitric oxide synthase and cyclooxygenase in rat aorta in organ culture. Br. J. Pharmacol. 121:1997;125-133.
5. Chang M.-S., Lee W.-S., Teng C.-M., Lee H.-M., Sheu J.-R., Hsiao G., Lin C.-H. YC-1 increases cyclooxygenase-2 expression through protein kinase G- and p44/42 mitogen-activated protein kinase-dependent pathways in A549 cells. Br. J. Pharmacol. 136:2002;558-567.
6. Charette L., Misquitta C., Guay J., Riendeau D., Jones T.R. Involvement of cyclooxygenase 2 (COX-2) in intrinsic tone of isolated guinea pig trachea. Can. J. Physiol. Pharmacol. 73:1995;1561-1567.
7. Connolly C., McCormick P.A., Docherty J.R. Effects of the selective cyclooxygenase-2 inhibitor nimesulide on vascular contractions in endothelium-denuded rat aorta. Eur. J. Pharmacol. 352:1998;53-58.
8. Copeland R.A., Williams J.M., Giannaras J., Nurnberg S., Covinton M., Pinto D., Pick S., Trzaskos J.M. Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase. Proc. Natl. Acad. Sci. U. S. A. 91:1994;11202-11206.
9. Cryer B., Dubois A. The advent of highly selective inhibitors of cyclooxygenase - a review. Prostaglandins Other Lipid Mediat. 56:1998;341-361.
10. De Witt D.L., Smith W.L. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complimentary DNA sequence. Proc. Natl. Acad. Sci. U. S. A. 85:1988;1412-1416.
11. Eberhart C.E., Coffey R.J., Radhika A., Giardiello F.M., Ferrenbach S., DuBois R.N. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology. 107:1994;1183-1188.
12. Funk C.D., Funk L.B., Kennedy M.E., Pong A.S., Fitzgerald G.A. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression and gene chromosomal assignment. FASEB J. 5:1991;2304-2312.
13. Futaki N., Yoshikawa K., Hamasaka Y., Arai L., Higuchi S., Iizuka M., Otomo S. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen. Pharmacol. 24:1993;105-110.
14. Futaki N., Takahashi S., Yokoyama M., Arai I., Higuchi S., Otomo S. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 47:1994;55-59.
15. Garcia-Cohen E.C., Marin J., Diez-Picazo L.D., Baena A.B., Salaices M., Rodriguez-Martinez M.A. Oxidative stress induced by tert-butyl hydroperoxide causes vasoconstriction in the aorta from hypertensive and aged rats: role of cyclooxygenase-2 isoform. J. Pharmacol. Exp. Ther. 293:2000;75-81.
16. Gilroy D.W., Tomlinson A., Willoughby D.A. Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation. Inflamm. Res. 47:1998;79-85.
17. 2+-transport ATPase in rat skeletal muscle sarcoplasmic reticulum vesicles. Biochem. Pharmacol. 37:1988;978-981.
18. Harris R.C., McKanna J.A., Akai Y., Jacobson H.R., Dubois R.N. Cyclooxygenase-2 is associated with the densa of rat kidney and increases with salt restriction. J. Clin. Invest. 94:1994;2504-2510.
19. Masferrer J.L., Zweifel B.S., Manning P.T., Hauser S.D., Leahy K.M., Smith W.G., Isakson P.C., Seibert K. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. U. S. A. 91:1994;3228-3232.
20. Meade E.A., Smith W.L., De Witt D.L. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 268:1993;6610-6614.
21. Merlie J.P., Fagan D., Mudd J., Needleman P. Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase). J. Biol. Chem. 263:1988;3550-3553.
22. Mitchell J.A., Warner T.D. Cyclooxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy. Br. J. Pharmacol. 128:1999;1121-1132.
23. Modin A., Bjorne H., Herulf M., Alving K., Weitzberg E., Lundberg J.O.N. Nitrite-derived nitric oxide: a possible mediator of acidic-metabolic vasodilation. Acta Physiol. Scand. 171:2001;9-16.
24. Muscara M.N., Vergnolle N., Lovren F., Triggle C.R., Elliot S.N., Asfaha S., Wallace J.L. Selective cyclooxygenase-2 inhibition with celecoxib elevates blood pressure and promotes leukocyte adherence. Br. J. Pharmacol. 129:2000;1423-1438.
25. O'Neil G.P., Mancini J.A., Kargman S., Yergery J., Kwan M.Y., Falqueyret J.P., Abromovitz M., Kennedy B.P., Ouellet M., Cromlish W., Culp S., Evans J.F., Ford-Hutchinson A.W., Vickers P.J. Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by non-steroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid. Mol. Pharmacol. 45:1994;245-254.
26. Riendeau D., Percival M.D., Boyce S., Brideau C.et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br. J. Pharmacol. 121:1997;105-117.
27. Ristimaki A., Honkanen N., Jankala H., Sipponen P., Harkonen M. Expression of cyclooxygenase-2 in human gastric carcinoma. Cancer Res. 57:1997;1276-1280.
28. 2+-ATPase of sarcoplasmic reticulum. J. Biol. Chem. 264:1989;17816-17823.
29. Simmons D.L., Xie W., Chipman J., Evett G.E. Multiple cyclooxygenase: cloning of mitogen-inducible form. Bailey J.M. Prostaglandins, Leukotrienes, Lipoxins and PAF. 1991;67-68 Plenum, New York.
30. Smith W.L., Meade E.A., De Witt D.L. Interactions of PGH synthase isozymes-1 and -2 with NSAIDs. Ann. N.Y. Acad. Sci. 744:1994;50-57.
31. Vane J.R. Inhibition of prostaglandins as a mechanism of action for aspirin-like drugs. Nature. 231:1971;232-235.
32. Vio C.P., Cespedes C., Gallardo P., Masferrer J.L. Renal identification of cyclooxygenase-2 in a subset of thick ascending limb cells. Hypertension. 30:1997;687-692.
33. Yamagata K., Andreasson K.I., Kaufmann W.E., Barnes C.A., Worley P.F. Expression of a mitogen-inducible cyclooxygenase in brain neurones: regulation by synaptic activity and glucocorticoids. Neuron. 11:1993;371-386.
34. Zimmermann K.C., Sarbia M., Weber A.A., Borchard F., Gabbert H.E., Schror K. Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res. 59:1999;198-204.