Clinical assessment of acne pathogenesis with treatment implications

International Pediatrics

Volumn 18, Issue 1, 2003, Pages 14-19

  Burkhart, Craig N ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Acne; Acne vulgaris; Adolescents; Propionibacterium acnes

Indexed keywords

ANTIBIOTIC AGENT; BENZOYL PEROXIDE; CYTOKINE; EPIDERMAL GROWTH FACTOR; IMMUNOLOGIC FACTOR; INTERLEUKIN 1ALPHA; ISOTRETINOIN; RETINAL; RETINOIC ACID; RETINOID; RETINOL; TAZAROTENE; TRANSFORMING GROWTH FACTOR ALPHA;

ACNE VULGARIS; ADOLESCENT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; COMEDO; DRUG MECHANISM; DRUG METABOLISM; HUMAN; INFLAMMATION; MEDICAL ASSESSMENT; PATHOGENESIS; PROPIONIBACTERIUM ACNES; REVIEW; SEBACEOUS GLAND; SEBUM; TREATMENT OUTCOME;

EID: 0037216001     PISSN: 08856265     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (18)

1. Burkhart CG, Burkhart CN, Lehmann PL. Acne: a review of immunologic and microbiologic factors. Postgrad Med J. 1999;75:328-31.
2. Kealey T, Guy R. Modelling the infundibulum in acne. J Invest Dermatol. 1997;108:376.
3. Guy R, Green MR, Kealey T. Modeling acne in vitro. J Invest Dermatol. 1996;106:176-82.
4. Bojar RA, Cunliffe WJ, Holland KT. The physiology of cutaneous microorganisms in a lipid-rich in vitro model of the pilosebaceous follicle. J Invest Dematol. 1997;108:380.
5. Kozlowska U, Blume-Peytavi U, Kodelja Y, Somner C, Goerdt S, Jablonska S, Orfanos CE. Proinflammatory interleukin-1 induces VEGF/VPF expression in cells of the human pilosebaceous unit. J Invest Dermatol. 1997;108:382.
6. Antilla HIS, Reitamo S, Saurat JH. Interleukin 1 immunoreactivity in sebaceous glands. Br J Dermatol. 1992;127:585-8.
7. Guy R, Kealey T. The organ maintained human sebaceous gland. J Invest Dermatol. 1997;108:372.
8. Guy R, Ridden CC, Barth JH, Kealey T. Isolation and maintenance of the human pilosebaceous duct: 13-cis retinoic acid acts directly on the duct in vitro. Br J Dermatol. 1993;128:242-8.
9. Seltmann H, Ruhl R, Seiffert K, Plum C, Orfanos CE, Nau H, Zouboulis CC. Isotretinoin treatment of human sebocytes in vitro results in low isotretinoin, but considerably elevated tretinoin intracellular levels and its effect is not affected by the presence of retinol. J Invest Dermatol. 1997;108:374.
10. Harms M, Hommel L, Geiger JM, Saurat JH. Effect of 3 stereoisomers of retinoic acid on the sebum excretion rate in subjects treated orally. J Invest Dermatol. 1997;108:375.
11. Paraskevaidis A, Drakoulis N, Roots J, Orfanos CE, Zouboulis CC. The role of cytochrome P-450 in acne. J Invest Dermatol. 1997;108:385.
12. Strauss JS, Kligman AM. The pathogenic dynamics of acne vulgaris. Arch Dermatol. 1960;82:779-90.
13. Parish WE, Barnett SE, Kealey T. An in vitro model for the infundibular changes in acne. J Invest Dermatol. 1997;108:377.
14. Zouboulis CC. New concepts in understanding sebaceous gland function. J Europ Acad Dermatol Venerol. 1995;5:S10.
15. Mavon A, Agache P, Gall Y, Humbert H. Sebum casual level restoration following washing: a mathematical modelisation. J Invest Dermatol. 1997;108:375.
16. Toyoda M, Morohashi M. Topical antibiotics in acne treatment. J Invest Dermatol. 1997;108:391.
17. Burkhart CN, Burkhart CG. Microbiologically acne vulgaris represents a biofilm. J Am Acad Dermatol (in revision).
18. Burkhart CN, Specht K, Neckers D. Synergistic activity of benzoyl peroxide and erythromycin. Skin Pharmacol Appl Skin Physiol. 2000;13:292-6.