Functional expression of chemokine receptor CCR5 on CD4+ T cells during virus-induced central nervous system disease

Journal of Virology

Volumn 77, Issue 1, 2003, Pages 191-198

  Glass, William G ^a   Lane, Thomas E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CHEMOKINE RECEPTOR CCR5; EPITOPE; MESSENGER RNA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL TRANSPORT; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DEMYELINATING DISEASE; DEMYELINATION; ENCEPHALOMYELITIS; MACROPHAGE; MOUSE; MULTIPLE SCLEROSIS; MURINE HEPATITIS CORONAVIRUS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VIRUS INFECTION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CENTRAL NERVOUS SYSTEM INFECTIONS; CORONAVIRUS INFECTIONS; DEMYELINATING DISEASES; MICE; MICE, INBRED C57BL; MURINE HEPATITIS VIRUS; RECEPTORS, CCR5;

EID: 0037213926     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.1.191-198.2003     Document Type: Article

References (58)

1. Akaike, T., E. Weihe, M. Schaefer, Z. F. Fu, Y. M. Zheng, W. Vogel, H. Schmidl, H. Koprowski, and B. Dielzschold. 1995. Effect of neurotropic virus infection on neuronal and inducible nitric oxide synthase activity in rat brain. J. Neurovirol. 1:118-125.
2. + T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int. Immunol. 11:2035-2042.
3. Asensio, V. C., and I. L. Campbell. 1997. Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis. J. Virol. 71:7832-7840.
4. + T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions. Proc. Natl. Acad. Sci. USA 96:6873-6878.
5. Chen, B. P., W. A. Kuziel, and T. E. Lane. 2001. Lack of CCR2 results in increased mortality and impaired leukocyte activation and trafficking following infection of the central nervous system with a neurotropic coronavirus. J. Immunol. 167:4585-4592.
6. Dawson, T. C., M. A. Beck, W. A. Kuziel, F. Henderson, and N. Maeda. 2000. Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus. Am. J. Pathol. 156:1951-1959.
7. Dorries, R. 2001. The role of T-cell-mediated mechanisms in virus infections of the nervous system. Curr. Top. Microbiol. Immunol. 253:219-245.
8. Finke, D., U. G. Brinckmann, V. ter Meulen, and U. G. Liebert. 1995. Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis. J. Virol. 69:5469-5474.
9. Glass, W. G., B. P. Chen, M. T. Liu, and T. E. Lane. 2002. Mouse hepatitis virus infection of the central nervous system: Chemokine-mediated regulation of host defense and disease. Viral Immunol. 15:261-272.
10. Glass, W. G., M. T. Liu, W. A. Kuziel, and T. E. Lane. 2001. Reduced macrophage infiltration and demyelination in mice lacking the chemokine receptor CCR5 following infection with a neurotropic coronavirus. Virology 288:8-17.
11. Gogate, N., M. Bakhiet, K. Kristensson, E. Norrby, and T. Olsson. 1991. Gamma interferon expression and major histocompatibility complex induction during measles and vesicular stomatitis virus infections of the brain. J. Neuroimmunol. 31:19-26.
12. Hirano, N., T. Murakami, K. Fujiwara, and M. Matsumoto. 1978. Utility of mouse cell line DBT for propagation and assay of mouse hepatitis virus. Jpn. J. Exp. Med. 48:71-75.
13. Houtman, J. J., and J. O. Fleming. 1996. Pathogenesis of mouse hepatitis virus-induced demyelination. J. Neurovirol. 2:361-376.
14. Huffnagle, G. B., L. K. McNeil, R. A. McDonald, J. W. Murphy, G. B. Toews, N. Maeda, and W. A. Kuziel. 1999. Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J. Immunol. 163:4642-4646.
15. Huffnagle, G. B., T. R. Traynor, R. A. McDonald, M. A. Olszewski, D. M. Lindell, A. C. Herring, and G. B. Toews. 2000. Leukocyte recruitment during pulmonary Cryptococcus neoformans infection. Immunopharmacology 48:231-236.
16. + virus peptide-specific T cells in Theiler's virus infection. FASEB J. 15:2760-2762.
17. + T cells in the central nervous system of susceptible SJL/J mice infected with Theiler's virus are virus specific and fully functional. J. Virol. 76:6577-6585.
18. Kundig, T. M., H. Hengartner, and R. M. Zinkernagel. 1993. T cell-dependent IFN-gamma exerts an antiviral effect in the central nervous system but not in peripheral solid organs. J. Immunol. 150:2316-2321.
19. Lane, T. E., V. C. Asensio, N. Yu, A. D. Paoletti, I. L. Campbell, and M. J. Buchmeier. 1998. Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease. J. Immunol. 160:970-978.
20. Lane, T. E., and M. J. Buchmeier. 1997. Murine coronavirus infection: A paradigm for virus-induced demyelinating disease. Trends Microbiol 5:9-14.
21. + T cells and RANTES in virus-induced central nervous system inflammation and demyelination. J. Virol. 74:1415-1424.
22. a. Lichterfeld, M., L. Leifeld, H. D. Nischalke, J. K. Rockstroh, L. Hess, T. Sauerbruch, and U. Spengler. 2002. Reduced CC chemokine receptor (CCR) 1 and CCR5 surface expression on peripheral blood T lymphocytes from patients with chronic hepatitis C infection. J. Infect. Dis. 185:1803-1807.
23. Lin, M. T., S. A. Stohlman, and D. R. Hinton. 1997. Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis. J. Virol. 71:383-391.
24. Liu, M. T., D. Armstrong, T. A. Hamilton, and T. E. Lane. 2001. Expression of Mig (monokine induced by interferon-gamma) is important in T lymphocyte recruitment and host defense following viral infection of the central nervous system. J. Immunol. 166:1790-1795.
25. Liu, M. T., B. P. Chen, P. Oertel, M. J. Buchmeier, D. Armstrong, T. A. Hamilton, and T. E. Lane. 2000. The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease. J. Immunol. 165:2327-2330.
26. Liu, M. T., B. P. Chen, P. Oertel, M. J. Buchmeier, T. A. Hamilton, D. A. Armstrong, and T. E. Lane. 2001. The CXC chemokines IP-10 and Mig are essential in host defense following infection with a neurotropic coronavirus. Adv. Exp. Med. Biol. 494:323-327.
27. Liu, M. T., H. S. Keirstead, and T. E. Lane. 2001. Neutralization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosis. J. Immunol. 167:4091-4097.
28. Luster, A. D. 1998. Chemokines - Chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338:436-445.
29. + T cells and viral spread to demyelinating disease. J. Immunol. 164:4080-4088.
30. Marten, N. W., S. A. Stohlman, and C. C. Bergmann. 2001. MHV infection of the CNS: Mechanisms of immune-mediated control. Viral Immunol. 14:1-18.
31. + T lymphocytes is effected through the Fas/FasL, but not the perforin pathway. Eur. J. Immunol. 30:3623-3633.
32. Miller, D. J., J. J. Bright, S. Sriram, and M. Rodriguez. 1997. Successful treatment of established relapsing experimental autoimmune encephalomyelitis in mice with a monoclonal natural autoantibody. J. Neuroimmunol. 75:204-209.
33. Murray, P. D., D. B. McGavern, L. R. Pease, and M. Rodriguez. 2002. Cellular sources and targets of IFN-gamma-mediated protection against viral demyelination and neurological deficits. Eur. J. Immunol. 32:606-615.
34. Neville, K. L., J. Padilla, and S. D. Miller. 2002. Myelin-specific tolerance attenuates the progression of a virus-induced demyelinating disease: Implications for the treatment of MS. J. Neuroimmunol. 123:18-29.
35. Palma, J. P., H. G. Lee, M. Mohindru, B. S. Kang, M. Dal Canto, S. D. Miller, and B. S. Kim. 2001. Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice. J. Neuroimmunol. 116:125-135.
36. + T cells contribute to CNS viral clearance. Adv. Exp. Med. Biol. 494:335-340.
37. Parra, B., D. R. Hinton, N. W. Marten, C. C. Bergmann, M. T. Lin, C. S. Yang, and S. A. Stohlman. 1999. IFN-gamma is required for viral clearance from central nervous system oligodendroglia. J. Immunol. 162:1641-1647.
38. Pasquetto, V., S. F. Wieland, S. L. Uprichard, M. Tripodi, and F. V. Chisari. 2002. Cytokine-sensitive replication of hepatitis B virus in immortalized mouse hepatocyte cultures. J. Virol. 76:5646-5653.
39. Pewe, L., J. Haring, and S. Perlman. 2002. CD4 T-cell-mediated demyelination is increased in the absence of gamma interferon in mice infected with mouse hepatitis virus. J. Virol. 76:7329-7333.
40. Pewe, L., and S. Perlman. 2002. Cutting edge: CD8 T cell-mediated demyelination is IFN-gamma dependent in mice infected with a neurotropic coronavirus. J. Immunol. 168:1547-1551.
41. + T cells and viral persistence. J. Virol. 76:2217-2224.
42. Robinson, J. H., and A. A. Delvig. 2002. Diversity in MHC class II antigen presentation. Immunology 105:252-262.
43. Rottman, J. B., A. J. Slavin, R. Silva, H. L. Weiner, C. G. Gerard, and W. W. Hancock. 2000. Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent. Eur. J. Immunol. 30:2372-2377.
44. Sato, N., W. A. Kuziel, P. C. Melby, R. L. Reddick, V. Kostecki, W. Zhao, N. Maeda, S. K. Ahuja, and S. S. Ahuja. 1999. Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient mice. J. Immunol. 163:5519-5525.
45. Sellebjerg, F., H. O. Madsen, C. V. Jensen, J. Jensen, and P. Garred. 2000. CCR5 δ32, matrix metalloproteinase-9 and disease activity in multiple sclerosis. J. Neuroimmunol. 102:98-106.
46. Sorensen, T. L., M. Tani, J. Jensen, V. Pierce, C. Lucchinetti, V. A. Folcik, S. Qin, J. Rottman, F. Sellebjerg, R. M. Strieter, J. L. Frederiksen, and R. M. Ransohoff. 1999. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J. Clin. Invest. 103:807-815.
47. Stohlman, S. A., C. C. Bergmann, D. J. Cua, M. T. Lin, S. Ho, W. Wei, and D. R. Hinton. 1998. Apoptosis of JHMV-specific CTL in the CNS in the absence of CD4+ T cells. Adv. Exp. Med. Biol. 440:425-430.
48. Stohlman, S. A., S. Kyuwa, J. M. Polo, D. Brady, M. M. Lai, and C. C. Bergmann. 1993. Characterization of mouse hepatitis virus-specific cytotoxic T cells derived from the central nervous system of mice infected with the JHM strain. J. Virol. 67:7050-7059.
49. + interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients. Ann. Neurol. 47:269-273.
50. + mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis. Am. J. Pathol. 159:1701-1710.
51. Vollstedt, S., M. Franchini, G. Alber, M. Ackermann, and M. Suter. 2001. Interleukin-12- and gamma interferon-dependent innate immunity are essential and sufficient for long-term survival of passively immunized mice infected with herpes simplex virus type 1. J. Virol. 75:9596-9600.
52. Walsb, C. M., M. Matloubian, C. C. Liu, R. Ueda, C. G. Kurahara, J. L. Christensen, M. T. Huang, J. D. Young, R. Ahmed, and W. R. Clark. 1994. Immune function in mice lacking the perforin gene. Proc. Natl. Acad. Sci. USA 91:10854-10858.
53. + T cells. J. Virol. 64:4589-4592.
54. Wu, G. F., A. A. Dandekar, L. Pewe, and S. Perlman. 2000. CD4 and CD8 T cells have redundant but not identical roles in virus-induced demyelination. J. Immunol. 165:2278-2286.
55. + T cell epitope within the M protein of a neurotropic coronavirus. Virology 208:173-179.
56. Yamaguchi, K., N. Goto, S. Kyuwa, M. Hayami, and Y. Toyoda. 1991. Protection of mice from a lethal coronavirus infection in the central nervous system by adoptive transfer of virus-specific T cell clones. J. Neuroimmunol. 32:1-9.
57. Zhuu, Y., T. Kurihara, R. P. Ryseck, Y. Yang, C. Ryan, J. Loy, G. Warr, and R. Bravo. 1998. Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor. J. Immunol. 160:4018-4025.
58. Zlotnik, A., and O. Yoshie. 2000. Chemokines: A new classification system and their role in immunity. Immunity 12:121-127.