The IRF-2 DNA binding domain facilitates the activation of the class II transactivator (CIITA) type IV promoter by IRF-1

Molecular Immunology

Volumn 39, Issue 11, 2003, Pages 677-684

  Xi, Hongkang ^a,c   Blanck, George ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CIITA; IRF 1; IRF 2; MHC class II; Transcription

Indexed keywords

DNA; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 2; PROTEIN DERIVATIVE; PROTEIN IRF E; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; COMPLEX FORMATION; DNA BINDING; GENE ACTIVATION; GENE DELETION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STABILITY; TRANSACTIVATION;

ANIMALS; BINDING SITES; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; INTERFERON REGULATORY FACTOR-1; INTERFERON REGULATORY FACTOR-2; INTERFERON TYPE II; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0037213718     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(02)00214-6     Document Type: Article

References (41)

1. Aragane Y., Schwarz A., Luger T., Ariizumi K., Takashima A., Schwarz T. Ultraviolet light suppresses IFN-γ-induced IL-7 gene expression in murine keratinocytes by interfering with IFN regulatory factors. J. Immunol. 158:1997;5393-5399.
2. Benech P., Vigneron M., Peretz D., Revel M., Chebath J. Interferon-response regulatory elements in the promoter of the human 2′, 5′-oligo (A) synthetase gene. Mol. Cell. Biol. 7:1987;4498-4504.
3. b. EMBO J. 8:1989;1139-1144.
4. Bovolenta C., Driggers P.H., Marks M.S., Medin J.A., Politis A.D., Vogel D.N., Levy D.E., Sakaguchi K., Appella E., Coligan J.E., Ozato K. Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family. Proc. Natl. Acad. Sci. U.S.A. 91:1994;5046-5050.
5. Briken V., Ruffner H., Schultz U., Schwarz A., Reis L.F.L., Strehlow I., Decker T., Staeheli P. Interferon regulatory factor 1 is required for mouse GBP gene activation by gamma interferon. Mol. Cell. Biol. 15:1995;975-982.
6. Cha Y., Deisseroth A.B. Human interferon regulatory factor 2 gene: intron-exon organization and functional analysis of 5′-flanking region. J. Biol. Chem. 269:1994;5279-5287.
7. Chang C.H., Hammer J., Loh J.E., Fodor W.L., Flavell R.A. The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1). Immunogenetics. 35:1992;378-384.
8. Escalante C., Yie J., Thanos D., Aggarwal A. Structure of IRF-1 with bound DNA reveals determinants of interferon regulation. Nature. 391:1998;103-106.
9. Faggioli L., Merola M., Hiscott J., Furia A., Monese R., Tovey M., Palmieri M. Molecular mechanisms regulating induction of interleukin-6 gene transcription by interferon-γ Eur. J. Immunol. 27:1997;3022-3030.
10. Fujii Y., Shimizu T., Kusumoto M., Kyogoku Y., Taniguchi T., Hakoshima T. Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences. EMBO J. 18:1999;5028-5041.
11. Fujita T., Sakakibara J., Sudo Y., Miyamoto M., Kimura Y., Taniguchi T. Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-β gene regulatory elements. EMBO J. 7:1988;3397-3405.
12. Harada H., Fujita T., Miyamoto M., Kimura Y., Maruyama M., Furia A., Miyata T., Taniguchi T. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell. 58:1989;729-739.
13. Harada H., Willison K., Sakakibara J., Miyamoto M., Fujita T., Taniguchi T. Absence of the type I IFN system in EC cells: transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated. Cell. 63:1990;303-312.
14. Harada H., Kitagawa M., Tanaka N., Yamamoto H., Harada K., Ishihara M., Taniguchi T. Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and 2. Science. 259:1993;971-974.
15. Harada H., Taniguchi T., Tanaka N. The role of interferon regulatory factors in the interferon system and cell growth control. Biochemie. 80:1998;641-650.
16. Jesse T.L., LaChance R., Iademarco M.F., Dean D.C. Interferon regulatory factor-2 is a transcriptional activator in muscle where it regulates expression of vascular cell adhesion molecule-1. J. Cell Biol. 140:1998;1265-1276.
17. Koenig Merediz S.A., Schmidt M., Hoppe G.J., Alfken J., Meraro D., Levi B.Z., Neubauer A., Wittig B. Cloning of an interferon regulatory factor 2 isoform with different regulatory ability. Nucl. Acids Res. 28:2000;4219-4224.
18. Lew D.J., Decker T., Strehlow I., Darnell J.E. Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. Mol. Cell. Biol. 11:1991;182-191.
19. Li-Weber M., Davydov I.V., Krafft H., Krammer P.H. The role of NF-Y and IRF-2 in the regulation of human IL-4 gene expression. J. Immunol. 153:1994;4122-4133.
20. phox promoter. J. Biol. Chem. 271:1996;23445-23451.
21. Matsuyama T., Kimura T., Kitagawa M., Pfeffer K., Kawakami T., Watanabe N., Kündig T.M., Amakawa R., Kishihara K., Wakeham A., Potter J., Furlonger C.L., Narendran A., Suzuki H., Ohashi P.S., Paige C.J., Taniguchi T., Mak T.W. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell. 75:1993;83-97.
22. Min W., Pober J.S., Johnson D.R. Kinetically coordinated induction of TAP1 and HLA class I by IFN-γ. The rapid induction of TAP1 by IFN-γ is mediated by stat1 alpha. J. Immunol. 156:1996;3174-3183.
23. Muhlethaler-Mottet O., Otten L.A., Steimle V., Mach B. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J. 16:1997;2851-2860.
24. Nguyen H., Hiscott J., Pitha P.M. The growing family of interferon regulatory factors. Cytokine Growth Factor Rev. 8:1997;293-312.
25. Schaefer B.C., Paulson E., Strominger J.L., Speck S.H. Constitutive activation of Epstein-Barr virus (EBV) nuclear antigen gene transcription by IRF1 and IRF2 during restricted EBV latency. Mol. Cell. Biol. 17:1997;873-886.
26. Sharf R., Azriel A., Lejbkowicz F., Winograd S.S., Ehrlich R., Levi B.Z. Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors. J. Biol. Chem. 270:1995;13063-13069.
27. Sharf R., Meraro D., Azriel A., Thornton A.M., Ozato K., Petricoin E.F., Larner A.C., Schaper F., Hauser H., Levi B.Z. Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA. J. Biol. Chem. 272:1997;9785-9792.
28. Spink J., Evans T. Binding of the transcription factor interferon regulatory factor-1 to the inducible nitric-oxide synthase promoter. J. Biol. Chem. 272:1997;24417-24425.
29. Steimle V., Siegrist C.A., Mottet A., Lisowska-Grospierre B., Mach B. Regulation of MHC class II expression by interferon-γ mediated by the transactivator gene CIITA. Science. 265:1994;106-109.
30. Tanaka N., Kawakami T., Taniguchi T. Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system. Mol. Cell. Biol. 13:1993;4531-4538.
31. Taniguchi T., Harada H., Lamphier M. Regulation of the interferon system and cell growth by the IRF transcription factors. J. Cancer Res. Clin. Oncol. 121:1995;516-520.
32. Taniguchi T., Lamphier M.S., Tanaka N. IRF-1: the transcription factor linking the interferon response and oncogenesis. Biochim. Biophys. Acta. 1333:1997;M9-M17.
33. Vaughan P.S., Aziz F., van Wijnen A.J., Wu S., Harada H., Taniguchi T., Soprano K.J., Stein J.L., Stein G.S. Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor-2. Nature. 377:1995;362-365.
34. Vaughan P.S., van der Meijden C.M.J., Aziz F., Harada H., Taniguchi T., van Wijnen A.J., Stein J.L., Stein G.S. Cell cycle regulation of histone H4 gene transcription requires the oncogenic factor IRF-2. J. Biol. Chem. 273:1998;194-199.
35. Watanabe N., Sakakibara J., Hovanessian A.G., Taniguchi T., Fujita T. Activation of IFN-β element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis. Nucl. Acids Res. 19:1991;4421-4428.
36. -/- mice. Immunity. 5:1996;365-376.
37. Wright K.L., White L.C., Kelly A., Beck S., Trowsdale J., Ting J.P.Y. Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter. J. Exp. Med. 181:1995;1459-1471.
38. Xi H., Eason D.D., Ghosh D., Dovhey S., Wright K.L., Blanck G. Co-occupancy of the interferon regulatory element of the class II transactivator (CIITA) type IV promoter by interferon regulatory factors 1 and 2. Oncogene. 18:1999;5889-5903.
39. Xi, H., Goodwin, B., Shepherd, A.T., Blanck, G., in press. Impaired class II transactivator expression in mice lacking interferon regulatory factor-2. Oncogene.
40. Xie Q.W., Whisnant R., Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide. J. Exp. Med. 177:1993;1779-1784.
41. Yamamoto H., Lamphier M., Fujita T., Taniguchi T., Harada H. The oncogenic transcription factor IRF-2 possesses a transcriptional repression and latent activation domain. Oncogene. 9:1994;1423-1428.