Discovery of a series of (4,5-Dihydroimidazol-2-yl)-biphenylamine 5-HT7 agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 2, 2003, Pages 269-271

  Parikh, Vinod ^a   Welch, Willard M ^a   Schmidt, Anne W ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(4,5 DIHYDROIMIDAZOL 2 YL)BIPHENYLAMINE; SEROTONIN AGONIST; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG; AMINOBIPHENYL DERIVATIVE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; IMIDAZOLE DERIVATIVE; SEROTONIN 7 RECEPTOR;

AGONIST; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CIRCADIAN RHYTHM; CONTROLLED STUDY; DRUG POTENCY; HYPERTENSION; LIGHT DARK CYCLE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ANIMAL; BLOOD PRESSURE; DRUG EFFECT; DRUG SCREENING; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

AMINOBIPHENYL COMPOUNDS; ANIMALS; BLOOD PRESSURE; DRUG EVALUATION, PRECLINICAL; IMIDAZOLES; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; RATS; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SPECTROPHOTOMETRY, INFRARED;

EID: 0037212109     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00925-3     Document Type: Article

References (10)

1. Schaus J.A., Bymaster F.P. Annu. Rep. Med. Chem. 33:1998;21.
2. Lovenberg T.W., Baron B.M., de Lecea L., Miller J.D., Prosser R.A., Rea M.A., Foye P.E., Racke M., Slone A.L., Siegel B.W. Neuron. 11:1993;449.
3. Delagrange P., Lemitre B.G. Clin. Neuropharm. 20:1997;482.
4. Lu J.Q., Nagayama H. Cell Mol. Life Sci. 53:1977;224.
5. Kennaway D.J., Rowe S.A., Ferguson S.A. Brain Res. 737:1996;301.
6. Salomon Y., Londos C., Rodbell M. Anal. Biochem. 58:1974;541.
7. Fukaya C., Takemoto T. J. Med. Chem. 37:1994;18.
8. Ankerson M., Crider M., Stidsen C. J. Am. Chem. Soc. 120:1998;1368.
9. Helegen L., Stoutland O., Agre C.L. J. Org. Chem. 24:1959;884.
10. Loev B., Hoeven H.V. J. Med. Chem. 26:1983;1769.