Substituted acrylophenones and related mannich bases as possible spermicides and inhibitors of HIV envelope glycoprotein-CD4 interaction

European Journal of Medicinal Chemistry

Volumn 37, Issue 11, 2003, Pages 855-864

  Kumaria, Niharika ^a   Dwivedi, Anil Kumar ^a   Maikhuri, Jagdamba Prasad ^a   Gupta, Gopal ^a   Habib, Saman ^a   Dhar, Janak Dulari ^a   Singh, Satyawan ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

2 Dialkylaminomethyl 1 4 (dialkylaminoalkoxy)phenyl prop 2 en 1 one and 4 dialkylaminomethyl 1 4 (dialkylaminoalkoxy)phenyl penta 1,4 dien 3 one; HIV Env CD4 interaction; Mannich bases; Spermicides

Indexed keywords

2 MORPHOLINOMETHYL 1 [5 ISOPROPYL 2 METHYL 4 (2 HYDROXY 3 PIPERIDINOPROPOXY)PHENYL]PROP 2 EN 1 ONE; 2 PIPERIDINOMETHYL 1 [4 (2 PIPERIDINOETHOXY)PHENYL]PROP 2 EN 1 ONE; 2 PIPERIDINOMETHYL 1 [4 (2 PYRROLIDINOMETHOXY)PHENYL]PROP 2 EN 1 ONE; 2 PIPERIDINOMETHYL 1 [4 (3 PIPERIDINOPROPOXY)PHENYL]PROP 2 EN 1 ONE; 2 PIPERIDINOMETHYL 1 [5 ISOPROPYL 2 METHYL 4 (2 HYDROXY 3 PIPERIDINOPROPOXY)PHENYL]PROP 2 EN 1 ONE; 2 PIPERIDINOMETHYL 1 [5 ISOPROPYL 2 METHYL 4 (2 HYDROXY 3 PYRROLIDINOPROPOXY)PHENYL]PROP 2 EN 1 ONE; 2 PYRROLIDINOMETHYL 1 [4 (3 PIPERIDINOPROPOXY)PHENYL]PROP 2 EN 1 ONE; 4 PIPERIDINOMETHYL 1 [4 (3 PIPERIDINOPROPOXY)PHENYL]PENTA 1,4 DIEN 3 ONE; CD4 ANTIGEN; KETONE DERIVATIVE; MANNICH BASE; PROTEIN INHIBITOR; RECOMBINANT ANTIGEN; RECOMBINANT PROTEIN; SPERMICIDAL AGENT; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZENE DERIVATIVE; GLYCOPROTEIN GP 160; KETONE;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; INFRARED SPECTROSCOPY; MALE; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; CELL LINE; DRUG EFFECT; METABOLISM; PROTEIN BINDING; SPERMATOZOON; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-HIV AGENTS; ANTIGENS, CD4; BENZENE DERIVATIVES; CELL LINE, TRANSFORMED; HIV ENVELOPE PROTEIN GP160; HUMANS; KETONES; MALE; MANNICH BASES; PROTEIN BINDING; SPERMATOCIDAL AGENTS; SPERMATOZOA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037210258     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(01)01292-2     Document Type: Article

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