Is KL-6 a serum indicator of early pulmonary fibrosis in childhood cancer patients?

Medical and Pediatric Oncology

Volumn 40, Issue 1, 2003, Pages 44-47

  Briassoulis, George ^a   Stefanaki, Kalliopi ^a   Peristeri, Ioulia ^a   Endoh, Yasuhiro ^b   Hatzis, Tassos ^a  

^a AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

^b Saiseikai Kurihashi Hospital   (Japan)

Author keywords

Acute lymphoblastic leukemia; Adult respiratory distress syndrome; Amiodarone pulmonary toxicity; Lung biopsy; Pulmonary fibrosis

Indexed keywords

ACICLOVIR; AMIODARONE; AMPHOTERICIN B LIPID COMPLEX; CARBOHYDRATE ANTIGEN; DOBUTAMINE; ISOPRENALINE; ITRACONAZOLE; KL 6 ANTIGEN; TEICOPLANIN; THYROID HORMONE DERIVATIVE; THYRORMONE; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; BONE MARROW TRANSPLANTATION; CASE REPORT; CHILD; CHILDHOOD CANCER; HEART VENTRICLE TACHYCARDIA; HUMAN; LUNG ALVEOLUS CELL; LUNG FIBROSIS; LUNG TOXICITY; MALE; PRIORITY JOURNAL;

AMIODARONE; ANTI-ARRHYTHMIA AGENTS; ANTIGENS; ANTIGENS, NEOPLASM; BIOLOGICAL MARKERS; BIOPSY; BONE MARROW TRANSPLANTATION; CHILD, PRESCHOOL; GLYCOPROTEINS; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; MALE; MUCINS; PULMONARY FIBROSIS; RESPIRATORY DISTRESS SYNDROME, ADULT; TACHYCARDIA, VENTRICULAR;

EID: 0037210154     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/mpo.10200     Document Type: Article

References (14)

1. Nakajima M, Kawahara Y, Yoshida K, et al. Serum KL-6 as a possible marker for amiodarone-induced pulmonary toxicity. Intern Med 2000;39:1004-1005.
2. Endoh Y, Hanai R, Uto K, et al. Diagnostic usefulness of KL-6 measurements in patients with pulmonary complications after administration of amiodarone. J Cardiol 2000;35:121-127.
3. Ashrafian H, Davey P. Is amiodarone an underrecognized cause of acute respiratory failure in the ICU? Chest 2001;120:275-282.
4. Bolt MW, Card JW, Racz WJ, et al. Disruption of mitochondrial function and cellular ATP levels by amiodarone and N-desethylamiodarone in initiation of amiodarone-induced pulmonary cytotoxicity. J Pharmacol Exp Ther 2001;298:1280-1289.
5. Inoue Y, Barker E, Daniloff E, et al. Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. Am J Respir Crit Care Med 1997;156:109-115.
6. Yokoyama A, Kohno N, Hamada H, et al. Circulating KL-6 predicts the outcome of rapidly progressive idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1998;158:1680-1684.
7. Dimopoulou I, Marathias K, Daganou M, et al. Low-dose amiodarone-related complications after cardiac operations. J Thorac Cardiovasc Surg 1997;114:31-37.
8. Endoh Y, Hanai R, Uto K, et al. Diagnostic accuracy of KL-6 as a marker of amiodarone-induced pulmonary toxicity. Pacing Clin Electrophysiol 2000;23:2010-2013.
9. Chesnutt AN, Matthay MA, Tibayan FA, et al. Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance. Am J Respir Crit Care Med 1997;156:840-845.
10. Kajiume T, Yoshimi S, Nagita A, et al. A case of myelodysplastic syndrome complicated by pulmonary alveolar proteinosis with a high serum KL-6 level. Pediatr Hematol Oncol 1999;16:367-371.
11. Takahashi T, Ebihara Y, Manabe A, et al. Surfactant protein D and KL-6 as serologic indicators of Pneumocystis carinii pneumonia in a child with acute lymphoblastic leukemia. J Med 2001;32:41-51.
12. Shankar G, Cohen DA. Idiopathic pneumonia syndrome after bone marrow transplantation: The role of pre-transplant radiation conditioning and local cytokine dysregulation in promoting lung inflammation and fibrosis. Int J Exp Pathol 2001;82:101-113.
13. Kopko PM, Popovsky MA, MacKenzie MR, et al. HLA class II antibodies in transfusion-related acute lung injury. Transfusion 2001;41:1244-1248.
14. Kohno N, Akiyama M, Kyoizumi S, et al. Detection of soluble tumor-associated antigens in sera and effusions using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma. Jpn J Clin Oncol 1988;18:203-216.