Identification and characterization of small cells in the adult pancreas: Potential progenitor cells?

Cell and Tissue Research

Volumn 310, Issue 1, 2002, Pages 51-58

  Petropavlovskaia, Maria ^a   Rosenberg, Lawrence ^a  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

Canine; Culture; Human; Pancreatic islet; Progenitor cell

Indexed keywords

ALPHA FETOPROTEIN; ARGININE; CYTOKERATIN 19; GLUCAGON; GLUCOSE; INSULIN; ISOBUTYLMETHYLXANTHINE; NESTIN; PANCREAS POLYPEPTIDE; PROTEIN BCL 2; SOMATOSTATIN; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL ISOLATION; CELL MATURATION; CELL PROLIFERATION; CELL SECRETION; CELL SIZE; CELL STRUCTURE; CELL TYPE; CONTROLLED STUDY; CYTOLOGY; DOG; GRANULE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; MITOCHONDRION; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SYNTHESIS; STEM CELL; TISSUE CULTURE;

ALPHA-FETOPROTEINS; ANIMALS; CELLS, CULTURED; DIABETES MELLITUS; DOGS; GLUCAGON; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICROSCOPY, ELECTRON; PANCREATIC POLYPEPTIDE; PROTO-ONCOGENE PROTEINS C-BCL-2; SOMATOSTATIN; STEM CELLS; SYNAPTOPHYSIN; TRANS-ACTIVATORS;

ANIMALIA; CANIS FAMILIARIS;

EID: 0037209494     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-002-0614-z     Document Type: Article

References (25)

1. Anderson DA (2001) Stem cells and pattern formation in the nervous system: the possible versus the actual. Neuron 30:19-35
2. Bonner-Weir S (2000) Perspective: postnatal pancreatic β cell growth. Endocrinology 141:1926-1929
3. Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE (1993) A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42:1715-1720
4. Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz K, Song K-H, Sharma A, O'Neil JJ (2000) In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 97:7999-8004
5. Bouwens L, Pipeleers DG (1998) Extra-insular beta cells associated with ductules are frequent in adult human pancreas. Diabetologia 41:629-633
6. Fernandes A, King LC, Guz Y, Stein R, Wright CVE, Teitelman G (1997) Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology 138:1750-1762
7. Fortunel N, Batard P, Hatzfeld A, Monier M-N, Panterne B, Lebkowski J, Hatzfeld J (1998) High proliferative potential-quiescent cells: a working model to study primitive quiescent hematopoietic cells. J Cell Sci 111:1867-1875
8. Fuchs E, Segre JA (2000) Stem cells: a new lease on life. Cell 100:143-155
9. Gu D, Sarvetnick N (1993) Epithelial cell proliferation and islet neogenesis in IFN-γ transgenic mice. Development 118:33-46
10. Guz Y, Nasir I, Teitelman G (2001) Regeneration of pancreatic β cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology 142:4956-4968
11. Kritzik MR, Jones E, Chen Z, Krakowski M, Krahl T, Good A, Wright C, Fox H, Sarvetnick N (1999) PDX-1 and Msx-2 expression in the regenerating and developing pancreas. J Endocr 163:523-530
12. Madsen OD, Jensen J, Blume N, Petersen HV, Lund K, Karlsen C, Andersen FG, Jensen PB, Larsson L-I, Serup P (1996) Pancreatic development and maturation of the islet β cell studies of pluripotent islet cultures. Eur J Biochem 242:435-445
13. Ohlsson H, Karlsson K, Edlund T (1993) IPF-1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12:4251-4259
14. Paraskevas S, Aikin R, Maysinger D, Lakey JRT, Cavanagh TJ, Hering B, Wang R, Rosenberg L (1999) Activation and expression of ERK, JNK, and p38 MAP-kinases in isolated islets of Langerhans: implications for cultured islet survival. FEBS Lett 455:203-208
15. Rafaeloff R, Pittenger GL, Barlow SW, Qin XF, Yan B, Rosenberg L, Duguid WP (1997) Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J Clin Invest 99:2100-2109
16. Ramiya VK, Maraist M, Arfors KE, Schatz DA, Peck AB, Cornelius JG (2000) Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nature Med 6:278-282
17. Richards J, Larson L, Yang J (1983) Method for culturing mammary epithelial cells in rat tail matrix. J Tissue Cult Methods 8:31-36
18. Rosenberg L (1998) Induction of islet cell neogenesis in the adult pancreas: the partial duct obstruction model. Microsc Res Tech 43:337-346
19. Rosenberg L, Brown RA, Diguid WP (1983) A new model for the development of duct epithelial hyperplasia and the initiation of nesidioblastosis. J Surg Res 35:63-72
20. Sharma A, Zangen DH, Reitz P, Taneja M, Lissauer ME, Miller CP, Weir GC, Habener JF, Bonner-Weir S (1999) The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 48:507-513
21. Soria B, Skoudy A, Martin F (2001) From stem cells to beta cells: new strategies in cell therapy of diabetes mellitus. Diabetologia 44:407-415
22. Wang RN, Rosenberg L (1999) Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship. J Endocrinol 163:181-190
23. Weissman IL (2000) Stem cells: units of development, units of regeneration, and units in evolution. Cell 100:157-168
24. Yuan S, Rosenberg L, Paraskevas S, Agapitos D, Duguid WP (1996) Transdifferentiation of human islets to pancreatic ductal cells in collagen matrix culture. Differentiation 61:67-75
25. Zulewski H, Abraham EJ, Gerlach MJ, Daniel PB, Moritz W, Müller B, Vallejo M, Thomas MK, Habener JF (2001) Multi-potential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50:523-533