Genistein inhibits Ca2+ influx and glutamate release from hippocampal synaptosomes: Putative non-specific effects

Neurochemistry International

Volumn 42, Issue 2, 2003, Pages 179-188

  Pereira, Daniela B ^a   Carvalho, Arsélio P ^a   Duarte, Carlos B ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Ca2+ influx; Glutamate release; Hippocampal synaptosomes; Tyrosine phosphorylation

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; DEPHOSTATIN; GENISTEIN; GLUTAMIC ACID; HERBIMYCIN A; ISOFLAVONE DERIVATIVE; LAVENDUSTIN A; NITRENDIPINE; OMEGA CONOTOXIN GVIA; OMEGA CONOTOXIN IVA; POTASSIUM CHLORIDE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG; VANADATE SODIUM; CALCIUM; ENZYME INHIBITOR; OMEGA AGATOXIN IVA; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EVOKED RESPONSE; HIPPOCAMPUS; MALE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; DRUG ANTAGONISM; ENZYMOLOGY; IMMUNOBLOTTING; IN VITRO STUDY; METABOLISM; NERVE ENDING; PHOSPHORYLATION; SYNAPTOSOME; WISTAR RAT;

ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; ENZYME INHIBITORS; GENISTEIN; GLUTAMIC ACID; HIPPOCAMPUS; IMMUNOBLOTTING; MALE; NERVE ENDINGS; OMEGA-AGATOXIN IVA; PHOSPHORYLATION; POTASSIUM CHLORIDE; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; RATS; RATS, WISTAR; SYNAPTOSOMES;

EID: 0037207465     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(02)00071-2     Document Type: Article

References (61)

1. Akiwama T., Ishida J., Nakagawa S., Ogawara H., Watnabe S.-I., Itoh N., Shibuya M., Fukami Y. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262:1987;5592-5595.
2. Akiwama T., Ogawara H. Use and specificity of genistein as inhibitor of protein-tyrosine kinases. Methods Enzymol. 201:1991;362-370.
3. 1 receptor. Eur. J. Pharmacol. 340:1997;301-310.
4. Barrie A., Chieregatti E., Miloso M., Benfenati F., Valtorta F. Epidermal growth factor-mediated inhibition of neurotransmitter glutamate release from rat forebrain synaptosomes. Mol. Pharmacol. 49:1996;399-403.
5. Cataldi M., Taglialatela M., Guerriero S., Amoroso S., Lombardi G., di Renzo G., Annunziato L. Protein-tyrosine kinases activate while protein-tyrosine phosphatases inhibit L-type calcium channel activity in pituitary GH3 cells. J. Biol. Chem. 271:1996;1039-1044.
6. Chiang C.-E., Chen S.-A., Chang M.-S., Lin C.-I., Luk H.-N. Genistein directly inhibits L-type calcium currents but potentiates cAMP-dependent chloride currents in cardiomyocytes. Biochem. Biophys. Res. Commun. 223:1996;598-603.
7. Cox M.E., Ely C.M., Catling A.D., Weber M.J., Parsons S.J. Tyrosine kinases are required for catecholamine secretion and mitogen-activated protein kinase activation in bovine adrenal chromaffin cells. J. Neurochem. 66:1996;1103-1112.
8. i responses to membrane depolarization. Neurochem. Int. 28:1996;67-75.
9. Dunkley P.R., Heath J.W., Harrison S.M., Jarvie P.E., Glenfield P.J., Rostas J.A.P. A rapid Percoll gradient procedure for isolation of synaptosomes directly from an S1 fraction: homogeneity and morphology of subcellular fractions. Brain Res. 441:1988;59-71.
10. A receptor function by tyrosine kinase inhibitors and their inactive analogues. Mol. Cell. Neurosci. 12:1998;300-310.
11. Ellis P.D., Bisson N., Gurd J.W. Synaptic protein-tyrosine kinase: partial characterization and identification of endogenous substrates. J. Neurochem. 51:2000;611-620.
12. - channels via a tyrosine kinase- and protein phosphatase-independent mechanism. Am. J. Physiol. 42:1997;C747-C753.
13. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:1985;3440-3450.
14. Gurd J.W. Protein-tyrosine phosphorylation - implication for synaptic function. Neurochem. Int. 31:1997;635-649.
15. Hilborn M.D., Vaillancourt R.R., Rane S.G. Growth factor receptor tyrosine kinases acutely regulate neuronal sodium channels through the src signaling pathway. J. Neurosci. 18:1998;590-600.
16. Hirano A.A., Greengard P., Huganir R.L. Protein-tyrosine kinase activity and its endogenous substrates in rat brain: a subcellular and regional survey. J. Neurochem. 50:1988;1447-1455.
17. Holmes T.C., Fadool D.A., Levitan I.B. Tyrosine phosphorylation of the Kv1.3 potassium channel. J. Neurosci. 16:1996;1581-1590.
18. Huang C.C., Hsu K.S. Protein-tyrosine kinase is required for the induction of long-term potentiation in the rat hippocampus. J. Physiol. Lond. 520:1999;783-796.
19. Huang R.Q., Dillon G.H. Direct inhibition of glycine receptors by genistein, a tyrosine kinase inhibitor. Neuropharmacol. 39:2000;2195-2204.
20. Huang X.Y., Morielli A.D., Peralta E.G. Tyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled m1 muscarinic acetylcholine receptor. Cell. 75:1993;1145-1156.
21. Imoto M., Kakeya H., Sawa T., Hayashi C., Hamada M., Takeuchi T., Umezawa K. Dephostatin, a novel protein-tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, isolation, and characterization. J. Antibiotics. 46:1993;1342-1346.
22. Janz R., Sudhof T.C., Hammer R.E., Unni V., Siegelbaum S.A., Bolshakov V.Y. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron. 24:1999;687-700.
23. Jovanovic J.N., Czernik A.J., Fienberg A.A., Greengard P., Sihra T.S. Synapsins as mediators of BDNF-enhanced neurotransmitter release. Nat. Neurosci. 3:2000;323-329.
24. Jovanovic, J.N., Benfenati, F., Siow, Y.L., Sihra, T.S., Sanghera, J.S., Pelech, S.L., Czernik, A.J., 1996. Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions. Proc. Natl. Acad. Sci. U.S.A. 93, 3679-3683.
25. 2+-induced noradrenaline release by vanadate in PC12 cells: possible involvement of tyrosine phosphorylation. Brain Res. 854:2000;165-171.
26. Layne E. Spectrophotometric and turbidimetric methods for measuring proteins. Methods Enzymol. 3:1957;447-451.
27. Leßmann V., Heumann R. Modulation of unitary glutamatergic synapses by neurotrophin-4/5 or brain-derived neurotrophic factor in hippocampal microcultures - presynaptic enhancement depends on pre-established paired-pulse facilitation. Neuroscience. 86:1998;399-413.
28. 2+-induced regulation of ion channel and MAP kinase functions. Nature. 376:1995;737-745.
29. Levine, E.S., Dreyfus, C.F., Black, I.B., Plummer, M.R., 1995. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proc. Natl. Acad. Sci. U.S.A. 92, 8074-8077.
30. 2+ influx in hippocampal synaptosomes. Brain Res. 696:1995;242-245.
31. McMahon H.T., Forman P., Dolly J.O., Verhage M., Wiegant V., Nicholls D.G. Tetanus toxin and botulinun toxins types A and B inhibit glutamate, γ-aminobutyric acid, aspartate, and Met-enkephalin release from synaptosomes. J. Biol. Chem. 267:1992;21338-21343.
32. 2+ channel currents in NG108-15 cells. Pflügers Arch. Eur. J. Physiol. 436:1998;127-132.
33. 2+/calmodulin-dependent protein kinase II in rat hippocampus. Eur. J. Pharmacol. 309:1996;311-315.
34. Nicholls D.G. Release of glutamate, aspartate and γ-aminobutyric acid from isolated nerve terminals. J. Neurochem. 52:1989;331-341.
35. Nicholls D.G., Sihra T.S., Sanchez-Prieto J. Calcium-dependent and independent release of glutamate from synaptosomes monitored by continuous fluorimetry. J. Neurochem. 47:1987;50-57.
36. Nichols M.R., Morimoto B.H. Tyrosine kinase-independent inhibition of cyclic-AMP phosphodiesterase by genistein and tyrphostin 51. Arch. Biochem. Biophys. 366:1999;224-230.
37. O'Dell T.J., Kandel E.R., Grant S.G.N. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature. 353:1991;558-560.
38. Onoda T., Iinuma H., Sasaki Y., Hamada M., Isshiki K., Naganawa H., Takeuchi T., Tatsuta K., Umezawa K. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J. Nat. Prod. 52:1989;1252-1257.
39. Ostman A., Bohmer F.D. Regulation of receptor tyrosine kinase signaling by protein-tyrosine phosphatases. Trends Cell Biol. 11:2001;258-266.
40. Paillart C., Carlier E., Guedin D., Dargent B., Couraud F. Direct block of voltage-sensitive sodium channels by genistein, a tyrosine kinase inhibitor. J. Pharmacol. Exp. Therap. 280:1997;521-526.
41. Pang, D.T., Wang, J.K.T., Valtorta, F., Benfenati, F., Greengard, P., 1988. Protein-tyrosine phosphorylation in synaptic vesicles. Proc. Natl. Acad. Sci. U.S.A. 85, 762-766.
42. Patterson S.L., Abel T., Deuel T.A.S., Martin K.C., Rose J.C., Kandel E.R. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron. 16:1996;1137-1145.
43. Pereira, D.B., Carvalho, A.P., Duarte, C.B., 2000. Modulation of hippocampal synaptic plasticity by the ERK/MAPK pathway. In: Bos, J.L. (Ed), Molecular Mechanisms of Signal Transduction, Vol. A/316. IOS Press, Amsterdam, pp. 63-72.
44. + channel gating in mouse Schwann cells. J. Physiol. 519:1999;373-384.
45. Petrone A., Sap J. Emerging issues in receptor protein-tyrosine phosphatase function: lifting fog or simply shifting? J. Cell Sci. 113:2000;2345-2354.
46. Potier B., Rovira C. Protein-tyrosine kinase inhibitors reduce high-voltage activating calcium currents in CA1 pyramidal neurones from rat hippocampal slices. Brain Res. 816:1999;587-597.
47. Ratcliffe C.F., Qu Y., McCormick K.A., Tibbs V.C., Dixon J.E., Scheuer T., Catterall W.A. A sodium channel signaling complex: modulation by associated receptor protein-tyrosine phosphatase β Nat. Neurosci. 3:2000;437-444.
48. Satoh T., Uehara Y., Kaziro Y. Inhibition of interleukin 3 and granulocyte-macrophage colony-stimulating factor stimulated increase of active ras.GTP by herbimycin A, a specific inhibitor of tyrosine kinases. J. Biol. Chem. 267:1992;2537-2541.
49. FAK by glutamate and depolarization in rat hippocampus. J. Biol. Chem. 271:1996;28942-28946.
50. Siegelbaum S.A. Ion channel control by tyrosine phosphorylation. Cur. Biol. 4:1994;242-245.
51. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., Fujimoto E.K., Goeke N.M., Olson B.J., Klenk D.C. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150:1985;76-85.
52. Stenius K., Janz R., Sudhof T.C., Jahn R. Structure of synaptogyrin (p29) defines a novel synaptic vesicle protein. J. Cell Biol. 131:1995;1801-1809.
53. Strauss O., Mergler S., Wiederholt M. Regulation of L-type calcium channels by protein-tyrosine kinase and protein kinase C in cultured rat and human retinal pigment epithelial cells. FASEB J. 11:1997;859-867.
54. Swarup G., Cohen S., Garbers D.L. Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate. Biochem. Biophys. Res. Commun. 107:1982;1104-1109.
55. 2+ and glutamate release. J. Neurochem. 53:1989;1693-1699.
56. Uehara Y., Fukazawa H. Use and selectivity of herbimycin A as inhibitor of protein-tyrosine kinases. Methods Enzymol. 201:1991;370-379.
57. Van Vactor D. Protein-tyrosine phosphatases in the developing nervous system. Cur. Opin. Cell Biol. 10:1998;174-181.
58. Wang Y.T., Salter M.W. Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature. 369:1994;233-235.
59. Washizuka T., Horie M., Obayashi K., Sasayama S. Genistein inhibits slow component delayed-rectifier K currents via a tyrosine kinase-independent pathway. J. Mol. Cell. Cardiol. 30:1998;2577-2590.
60. Wijetunge S., Lymn J.S., Hughes A.D. Effect of inhibition of tyrosine phosphatases on voltage-operated calcium channel currents in rabbit isolated ear artery cells. Br. J. Pharmacol. 124:1998;307-316.
61. Woodrow S., Bisson N., Gurd J.W. Depolarization-dependent tyrosine phosphorylation in rat brain synaptosomes. J. Neurochem. 59:1992;857-862.