Unusual benefits of macromolecular shielding by polyethylene glycol for reactions at the diffusional limit: The case of factor VIIai and tissue factor

Biochemistry

Volumn 41, Issue 52, 2002, Pages 15820-15825

  Stone, Matthew ^a   Harvey, Stephen B ^a   Kisiel, Walter ^b   Foster, Donald ^c   Nelsestuen, Gary L ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c ZYMOGENETICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN ANTIGENICITY;

ANTIGENS; BLOOD; CHEMICAL BONDS; CHEMICAL MODIFICATION; COAGULATION; DIFFUSION; MACROMOLECULES; POLYETHYLENE GLYCOLS; PROTEINS; SHIELDING; TISSUE;

BIOCHEMISTRY;

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 9A; BLOOD CLOTTING FACTOR VIIAI; MACROGOL; PROTEIN; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTICOAGULATION; ANTIGENICITY; ARTICLE; CHEMICAL BINDING; CHEMICAL REACTION; CIRCULATION; DIFFUSION; FEMALE; HUMAN; KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN MODIFICATION;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANTICOAGULANTS; BINDING SITES; DIFFUSION; FACTOR IXA; FACTOR VIIA; FACTOR XA; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; ISOANTIBODIES; MACROMOLECULAR SUBSTANCES; MICE; MICE, INBRED BALB C; PARTIAL THROMBOPLASTIN TIME; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THROMBOPLASTIN;

ANIMALIA;

EID: 0037207114     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0204544     Document Type: Article

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