Involvement of the parabrachial nucleus in the pressor response to chemoreflex activation in awake rats

Autonomic Neuroscience: Basic and Clinical

Volumn 101, Issue 1-2, 2002, Pages 60-67

  Haibara, Andréa S ^a   Tamashiro, Edwin ^b   Olivan, Marcelo V ^b   Bonagamba, Leni G H ^b   Machado, Benedito H ^b  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Arterial chemoreflex; Cardiovascular regulation; Lidocaine; Parabrachial nucleus; Periaqueductal gray matter; Potassium cyanide; Sympathoexcitation

Indexed keywords

LIDOCAINE; LOCAL ANESTHETIC AGENT;

ANIMAL EXPERIMENT; ARTICLE; BRADYCARDIA; BRAIN REGION; CARDIOVASCULAR RESPONSE; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; MALE; NERVE CONDUCTION; NERVE TRACT; NONHUMAN; PARABRACHIAL NUCLEUS; PERIAQUEDUCTAL GRAY MATTER; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; TIME; WAKEFULNESS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BLOOD PRESSURE; ENZYME INHIBITORS; HEART RATE; LIDOCAINE; MALE; MICROINJECTIONS; PONS; POTASSIUM CYANIDE; RATS; RATS, WISTAR; REFLEX; SYMPATHETIC NERVOUS SYSTEM; TIME FACTORS; WAKEFULNESS;

EID: 0037206977     PISSN: 15660702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1566-0702(02)00210-2     Document Type: Article

References (44)

1. Aicher S.A., Saravay R.H., Cravo S., Jeske I., Morrison S.F., Reis D.J., Milner T.A. Monosynaptic projections from the nucleus tractus solitarii to C1 adrenergic neurons in the rostral ventrolateral medulla: comparison with input from the caudal ventrolateral medulla. J. Comp. Neurol. 373:1996;62-75.
2. Bandler R., Carrive P., Depaulis A. Emerging principles of organization of the midbrain periaqueductal gray. Depaulis A., Bandler R. The Midbrain Periaqueductal Gray Matter: Functional, Anatomical and Neurochemical Organization. 1991;1-8 Plenum, New York.
3. Bandler R., Carrive P., Zhang S.P. Integration of somatic and autonomic reactions within the midbrain periaqueductal gray: viscerotopic, somatotopic and functional organization. Prog. Brain Res. 87:1991;269-305.
4. Bester H., Besson J.M., Bernard J.F. Organization of efferent projections from the parabrachial area to the hypothalamus: a Phaseoulus vulgaris-leucoagglutinin study in the rat. J. Comp. Neurol. 383:1997;245-281.
5. Callera J.C., Sévoz C., Laguzzi R., Machado B.H. Microinjection of a serotonin3 receptor agonist into the NTS of unanesthetized rats inhibits the bradycardia evoked by activation of the baro- and the chemoreflex. J. Auton. Nerv. Syst. 63:1997;127-136.
6. B receptors in the NTS blocked bradycardia of chemoreflex in awake rats. Am. J. Physiol. 276(45):1999;H1902-H1910.
7. Carrive P., Dampney R.A.L., Bandler R. Excitation of neurons in a restricted portion of the midbrain periaqueductal gray elicits both behavioral and cardiovascular components of the defence reaction in the unanesthetized decerebrate cat. Neurosci. Lett. 81:1987;273-278.
8. Chamberlin N.L., Saper C.B. Topographic organization of cardiovascular responses to electrical and glutamate microstimulation of the parabrachial nucleus in the rat. J. Comp. Neurol. 326:1992;215-262.
9. Chamberlin N.L., Saper C.B. Topographic organization of respiratory responses to glutamate microstimulation of the parabrachial nucleus in the rat. J. Neurosc. 14(11):1994;6500-6510.
10. Ciriello J., Calaresu F.R. Monosynaptic pathway from cardiovascular neurons in the nucleus tractus solitarii to the paraventricular nucleus in the cat. Brain Res. 193:1980;529-533.
11. Ciriello J., Lawrence D., Pittman Q.J. Electrophysiological identification of neurons in the parabrachial nucleus projecting directly to the hypothalamus in the rat. Brain Res. 322:1984;388-392.
12. Ciriello J., Hochstenbach S.L., Roder S. Central projections of baroreceptor and chemoreceptor afferent fibers in the rat. Barraco I.R.A. Nucleus of the Solitary Tract. 1994;35-50 CRC, Orlando.
13. Coote J.H., Yang Z., Pyner S., Deering J. Control of sympathetic outflows by the hypothalamic paraventricular nucleus. Clin. Exp. Pharmacol. Physiol. 25:1998;461-463.
14. de Paula P.M., Machado B.H. Antagonism of adenosine A1 receptors in the NTS do not affect the chemoreflex in awake rats. Am. J. Physiol., Regul. Integr. Comp. Physiol. 281:2001;R2072-R2078.
15. Erickson J.T., Millhorn D.E. Hypoxia and electrical stimulation of the carotid sinus nerve induce Fos-like immunoreactivity within catecholaminergic and serotoninergic neurons of the rat brainstem. J. Comp. Neurol. 348:1994;161-182.
16. Franchini K.G., Krieger E.M. Cardiovascular responses of conscious rats to carotid body chemoreceptor stimulation by intravenous KCN. J. Auton. Nerv. Syst. 42:1993;63-70.
17. Fulwiler C.E., Saper C.B. Subnuclear organization of the efferent connections of the parabrachial nucleus in the rat. Brain Res. Rev. 7:1984;229-259.
18. Granata A.R. Ascending and descending convergent inputs to neurons in the nucleus parabrachialis of the rat: an intracellular study. Brain Res. 600:1993;315-321.
19. Granata A.R., Kitai S.T. Intracellular study of nucleus parabrachialis and nucleus tractus solitarii interconnections. Brain Res. 492:1989;281-292.
20. Guyenet P.G., Koshiya N. Respiratory-sympathetic integration in the medulla oblongata. Kunos G., Ciriello J. Central Neural Mechanisms in Cardiovascular Regularion. 1992;226-247 Birkhauser, Boston.
21. Haibara A.S., Colombari E., Chianca D.A. Jr., Bonagamba L.G.H., Machado B.H. NMDA receptors in NTS are involved in bradycardic but not in pressor response to chemoreflex. Am. J. Physiol. 269(38):1995;H1421-H1427.
22. Haibara A.S., Bonagamba L.G.H., Machado B.H. Sympathoexcitatory neurotransmission of the chemoreflex in the NTS of awake rats. Am. J. Physiol., Regul. Integr. Comp. Physiol. 276(45):1999;R69-R80.
23. Hayward L.F., Felder R.B. Peripheral chemoreceptor inputs to the parabrachial nucleus of the rat. Am. J. Physiol., Regul. Integr. Comp. Physiol. 268:1995;R707-R714.
24. Herbert H., Moga M.M., Saper C.B. Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. J. Comp. Neurol. 293:1990;540-580.
25. Koshiya N., Guyenet P.G. Tonic sympathetic chemoreflex after blockade of respiratory rhythmogenesis in the rat. J. Physiol. 491(3):1996;859-869.
26. Kubo T., Yanagihara Y., Yamaguchi H., Fukumori R. Excitatory amino acid receptor in the paraventricular hypothalamic nucleus mediate pressor response induced by carotid body chemoreceptor stimulation in rats. Clin. Exp. Hypertens. 19:1997;1117-1134.
27. Lara J.P., Parkes M.J., Silva-Carvalho L., Izzo P., Dawid-Milner M.S., Spyer K.M. Cardiovascular and respiratory effects of stimulation of cell bodies of the parabrachial nuclei in the anaesthetized rat. J. Physiol. 477(2):1994;321-329.
28. Loewy A.D. Central autonomic pathways. Loewy A.S., Spyer K.M. Central Regulation of Autonomic Functions. 1990;88-103 Oxford Univ. Press, New York.
29. Loewy A.D., Wallach J.H., McKellar S. Efferent connections of the ventral medulla oblongata in the rat. Brain Res. Rev. 3:1981;63-80.
30. Machado B.H., Bonagamba L.G.H. Microinjection of L-glutamate into the nucleus tractus solitarii increases arterial pressure in conscious rats. Brain Res. 576:1992;131-138.
31. Moga M.M., Herbert H., Hurley K.M., Yasui Y., Gray T.S., Saper C.B. Organization of cortical, basal forebrain, and hypothalamic afferents to the parabrachial nucleus in the rat. J. Comp. Neurol. 295:1990;624-661.
32. Mraovitch S., Kumada M., Reis D.J. Role of the nucleus parabrachialis in cardiovascular regulation in cat. Brain Res. 232:1982;57-75.
33. Olivan M.V., Bonagamba L.G.H., Machado B.H. Involvement of the paraventricular nucleus of the hypothalamus in the pressor response to chemoreflex activation in awake rats. Brain Res. 895:2001;167-172.
34. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 2nd ed. 1986;Academic Press, Sydney.
35. Ricardo J., Koh E.T. Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat. Brain Res. 153:1978;1-26.
36. Saper C.B., Swanson L.W., Cowan W.M. An autoradiographic study of the efferent connections of the lateral hypothalamic area in the rat. J. Comp. Neurol. 183:1979;689-706.
37. Silva-Carvalho L., Dawid-Milner M.S., Spyer K.M. Hypothalamic modulation of the arterial chemoreceptor reflex in the anaesthetized cat: role of the nucleus tractus solitarii. J. Physiol. 487:1995;751-760.
38. Spyer K.M. The central nervous organization of reflex circulatory control. Loewy A.S., Spyer K.M. Central Regulation of Autonomic Functions. 1990;168-188 Oxford Univ. Press, New York.
39. Takeuchi Y., Hopkins D.A. Light and electron microscopic demonstration of hypothalamic projections to the parabrachial nuclei in the cat. Neurosci. Lett. 46:1984;53-58.
40. Thomas M.R., Calaresu F.R. Responses of single units in the medial hypothalamus to electrical stimulation of the carotid sinus nerve in the cat. Brain Res. 44:1972;49-62.
41. Urbanski R.W., Sapru H.N. Evidence for a sympathoexcitatory pathway from the nucleus tractus solitarii to the ventrolateral medullary pressor área. J. Auton. Nerv. Syst. 23:1988;161-174.
42. Ward D. Stimulation of the parabrachial nuclei with monosodium glutamate increases arterial pressure. Brain Res. 462:1988;383-390.
43. Zhang C.H., Bonagamba L.G.H., Machado B.H. Blockade of NK-1 receptors in the nucleus tractus solitarii of awake rats produced no effect on cardiovascular responses to chemoreflex activation. Braz. J. Med. Biol. Res. 33:2000;1379-1385.
44. Zimpfer M., Sit S.P., Vatner S.F. Effects of anesthesia on the canine carotid chemoreceptor reflex. Circ. Res. 48:1981;400-406.