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Volumn 43, Issue 40, 2002, Pages 7229-7233

A structurally simple minimal self-replicating system

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPYRIDINE; AZIDE; CARBOXYLIC ACID; MALEIMIDE;

EID: 0037201149     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)01613-1     Document Type: Article
Times cited : (30)

References (30)
  • 10
    • 0003846069 scopus 로고
    • CUP Cambridge Clay Minerals and the Origin of Life; Cairns-Smith, A. G.; Hartman, H., Eds.; CUP: Cambridge, 1986
    • Cairns-Smith A.G. Genetic Takeover. 1982;CUP, Cambridge, Clay Minerals and the Origin of Life; Cairns-Smith, A. G.; Hartman, H., Eds.; CUP: Cambridge, 1986.
    • (1982) Genetic Takeover
    • Cairns-Smith, A.G.1
  • 23
    • 0010596381 scopus 로고    scopus 로고
    • Ph.D. Thesis, University of Birmingham
    • Booth, C. A. Ph.D. Thesis, University of Birmingham, 1998.
    • (1998)
    • Booth, C.A.1
  • 24
    • 0010596023 scopus 로고    scopus 로고
    • note
    • 2=0.1948.
  • 25
    • 0010561514 scopus 로고    scopus 로고
    • note
    • For a complete discussion, see: von Kiedrowski, G. Bioorg. Chem. Front. 1993, 3, 151. There has been considerable discussion in the literature concerning the benefits and drawbacks of using a minimal model compared to full kinetic modeling (Reinhoudt, D. N; Rudekevich, D. M.; de Jong, F. J. Am. Chem. Soc. 1996, 118, 6880). We have performed both minimal and full kinetic modeling on this system. The data from the full kinetic modeling is entirely consistent with the conclusions drawn here; however, its description is beyond the scope of this paper and will be presented elsewhere. The minimal modeling is presented here in order to set our system in the context of other replicating systems published previously.
  • 26
    • 0010561834 scopus 로고    scopus 로고
    • Only two of the three reaction channels are open to this system as reaction is impossible within the [A·B] complex as a result of the short methylene spacer between the maleimide and the carboxylic acid in B
    • Only two of the three reaction channels are open to this system as reaction is impossible within the [A·B] complex as a result of the short methylene spacer between the maleimide and the carboxylic acid in B.
  • 28
    • 0010630826 scopus 로고    scopus 로고
    • Systems based on nucleic acids have p values of around 0.5. Peptide-based systems (Ref. 5) have p values between 0.6 and 0.7. The Diels-Alder based system of Sutherland (Ref. 15) has a p value of 0.80 and our nitrone based system (Ref. 15) has a p value of 0.91
    • Systems based on nucleic acids have p values of around 0.5. Peptide-based systems ( Ref. 5 ) have p values between 0.6 and 0.7. The Diels-Alder based system of Sutherland ( Ref. 15 ) has a p value of 0.80 and our nitrone based system ( Ref. 15 ) has a p value of 0.91.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.