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0010596023
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note
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2=0.1948.
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25
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0010561514
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note
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For a complete discussion, see: von Kiedrowski, G. Bioorg. Chem. Front. 1993, 3, 151. There has been considerable discussion in the literature concerning the benefits and drawbacks of using a minimal model compared to full kinetic modeling (Reinhoudt, D. N; Rudekevich, D. M.; de Jong, F. J. Am. Chem. Soc. 1996, 118, 6880). We have performed both minimal and full kinetic modeling on this system. The data from the full kinetic modeling is entirely consistent with the conclusions drawn here; however, its description is beyond the scope of this paper and will be presented elsewhere. The minimal modeling is presented here in order to set our system in the context of other replicating systems published previously.
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26
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0010561834
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Only two of the three reaction channels are open to this system as reaction is impossible within the [A·B] complex as a result of the short methylene spacer between the maleimide and the carboxylic acid in B
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Only two of the three reaction channels are open to this system as reaction is impossible within the [A·B] complex as a result of the short methylene spacer between the maleimide and the carboxylic acid in B.
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28
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0010630826
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Systems based on nucleic acids have p values of around 0.5. Peptide-based systems (Ref. 5) have p values between 0.6 and 0.7. The Diels-Alder based system of Sutherland (Ref. 15) has a p value of 0.80 and our nitrone based system (Ref. 15) has a p value of 0.91
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Systems based on nucleic acids have p values of around 0.5. Peptide-based systems ( Ref. 5 ) have p values between 0.6 and 0.7. The Diels-Alder based system of Sutherland ( Ref. 15 ) has a p value of 0.80 and our nitrone based system ( Ref. 15 ) has a p value of 0.91.
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