Poly(lactic acid)-poly(ethylene oxide) (PLA-PEG) nanoparticles: NMR studies of the central solidlike PLA core and the liquid PEG corona

Langmuir

Volumn 18, Issue 9, 2002, Pages 3669-3675

  Heald, C R ^a   Stolnik, S ^a   Kujawinski, K S ^a   De Matteis, C ^a   Garnett, M C ^a   Illum, L ^a   Davis, Stanley S ^a   Purkiss, S C ^b   Barlow, R J ^b   Gellert, P R ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCK COPOLYMERS; DEPOSITION; EVAPORATION; INTERFACES (MATERIALS); NANOSTRUCTURED MATERIALS; NUCLEAR MAGNETIC RESONANCE; POLYETHYLENE OXIDES;

DIBLOCK COPOLYMERS;

ORGANIC ACIDS;

EID: 0037198234     PISSN: 07437463     EISSN: None     Source Type: Journal    
DOI: 10.1021/la011393y     Document Type: Article

References (30)

1. Fessi, H.; Devissaguet, J.P.; Puisieux, F.; Thies, C. French Patent 2 608 988, 1986.
2. Stolnik, S.; Heald, C.R.; Neal, J.; Garnett, M.C.; Davis, S.S.; Illum, L.; Purkiss, S.C.; Barlow, R.J.; Gellert, P.R. J. Drug Targeting 2001, 9, 361.
3. Peracchia, M.T.; Gref, R.; Minamitake, Y.; Domb, A.; Lotan, N.; Langer, R. J. Controlled Release 1997, 46, 223.
4. Riley, T.; Stolnik, S.; Heald, C.R.; Xiong, C.D.; Garnett, M.C.; Illum, L.; Davis, S.S.; Purkiss, S.C.; Barlow, R.J.; Gellert, P.R. Langmuir 2001, 17, 3168.
5. Hrkach, J.S.; Peracchia, M.T.; Domb, A.; Lotan, N.; Langer, R. Biomaterials 1997, 18, 27.
6. Govender, T.; Riley, T.; Ehtezazi, T.; Garnett, M.C.; Stolnik, S.; Illum, L.; Davis, S.S. Int. J. Pharm. 2000, 199, 95.
7. Riley, T.; Govender, T.; Stolnik, S.; Xiong, C.D.; Garnett, M.C.; Illum, L.; Davis, S.S. Colloids Surf., B 1999, 16, 147.
8. McGurk, S.; Sanders, G.H.W.; Davies, M.C.; Davis, S.S.; Illum, L.; Roberts, C.J.; Stolnik, S.; Tendler, S.J.B.; Williams, P.M. Polym. J. (Tokyo) 2000, 32, 444.
9. Kwon, G.S. Crit. Rev. Ther. Drug Carrier Syst. 1998, 15, 481.
10. Tanodekaew, S.; Pannu, R.; Heatley, F.; Attwood, D.; Booth, C. Macromol. Chem. Phys. 1997, 198, 927.
11. Dunn, S.E.; Brindley, A.; Davis, S.S.; Davies, M.C.; Illum, L. Pharm. Res. 1994, 11, 1016.
12. Heald, C.R.; Stolnik, S.; De Matteis, C.; Garnett, M.C.; Illum, L.; Davis, S.S.; Leermakers, F.A.M. Colloids Surf., A 2001, 179, 79.
13. Heald, C.R.; Stolnik, S.; De Matteis, C.; Garnett, M.C.; Illum, L.; Davis, S.S.; Leermakers, F.A.M. Colloids Surf., A, submitted.
14. Washington, C.; King, S.M. Langmuir 1997, 13, 4545.
15. Poly(ethyleneglycol) Chemistry - Biotechnical and Biomedical Applications; Harris, J.M., Ed.; Plenum Press: New York, 1992.
16. El Seoud, O.A.; Blaskó, A.; Bunton, C.A. Langmuir 1994, 10, 653.
17. El Seoud, O.A.; Farah, J.P.S.; El Seoud, O.A. Ber. Bunsen-Ges. Phys. Chem. 1989, 93, 180.
18. El Seoud, O.A.; Farah, J.P.S.; Vieira, P.C.; El Seoud, M.I. J. Phys. Chem. 1987, 91, 2950.
19. Nagy, J.B.; Bodart-Ravet, I.; Derouane, E.G.; Gourgue, A.; Verfaillie, J.P. Colloids Surf. 1989, 36, 229.
20. Podo, F.; Ray, A.; Nemethy, G. J. Am. Chem. Soc. 1973, 95, 6164.
21. Godward, J.; Heatley, F.; Booth, C. J. Chem. Soc., Faraday Trans. 1993, 89, 3471.
22. Ribeiro, A.A.; Dennis, E.A. J. Colloid Interface Sci. 1976, 55, 94.
23. Churchill, J.R.; Hutchinson, F.G. European Patent Application 0 092 918, 1983; European Patent Application 0 166 596, 1986.
24. Elworthy, P.H.; Patel, M.S. J. Pharm. Pharmacol. 1984, 36, 565.
25. Nilsson, P.G.; Wennerstroem, H.; Lindman, B. J. Phys. Chem. 1983, 87, 1377.
26. Ribeiro, A.A.; Dennis, E.A. J. Phys. Chem. 1977, 81, 957.
27. Cabdau, F.; Heatley, F.; Price, C.; Stubbersfield, R.B. Eur. Polym. J. 1984, 20, 685.
28. Godward, J.; Heatley, F.; Booth, C. J. Chem. Soc., Faraday Trans. 1995, 91, 1491.
29. Heatley, F.; Teo, H.H.; Booth, C. J. Chem. Soc., Faraday Trans. 1984, 80, 981.
30. Godward, J.; Heatley, F.; Smith, S.; Tanodekaew, S.; Yang, Y.-W.; Booth, C. J. Chem. Soc., Faraday Trans. 1995, 91, 3461.