Caution on the use of saliva measurements to monitor absorption of progesterone from transdermal creams in postmenopausal women

Maturitas

Volumn 41, Issue 1, 2002, Pages 1-6

  Lewis, John G ^a   McGill, Helen ^b   Patton, Vivienne M ^b   Elder, Peter A ^a  

^a CANTERBURY HEALTH LABORATORIES   (New Zealand)

^b Haelan House   (New Zealand)

Author keywords

Hormone replacement therapy; Postmenopause; Progesterone; Saliva; Transdermal

Indexed keywords

DRUG METABOLITE; GLUCURONIDE; PLACEBO; PREGNANEDIOL; PROGESTERONE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG METABOLISM; DRUG MONITORING; ERYTHROCYTE; FEMALE; HUMAN; HUMAN CELL; POSTMENOPAUSE; PREMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; SALIVA; TARGET ORGAN; TREATMENT OUTCOME;

ABSORPTION; ADMINISTRATION, CUTANEOUS; ADULT; AGED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ERYTHROCYTES; FEMALE; FINASTERIDE; HORMONE REPLACEMENT THERAPY; HUMANS; MIDDLE AGED; POSTMENOPAUSE; PREGNANEDIOL; PROGESTERONE; SALIVA;

EID: 0037196342     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5122(01)00250-X     Document Type: Article

References (13)

1. Systemic absorption of progesterone from Progest cream in postmenopausal women
2. Use of Pro-gest cream in postmenopausal women
3. Generation of monoclonal progesterone antibodies by electrofusion techniques
4. Re-examining steroid hormone metabolites as ovulation markers using monoclonal antibodies
5. Micronised transdermal progesterone and endometrial response
6. Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss
7. Percutaneous absorption of progesterone in postmenopausal women treated with transdermal estrogen
8. A study to evaluate serum and urinary hormone levels following short and long term administration of two regimens of progesterone cream in postmenopausal women
9. Salivary progesterone: Relation to total and non-protein-bound blood levels
10. The permeability of the human red cell membrane to steroid hormones
11. Salivary, but not serum or urinary levels of progesterone are elevated after topical application of progesterone cream to pre- and postmenopausal women
12. Progesterone metabolism in human saliva in vitro
13. The enzyme and inhibitors of 4-ene-3-oxosteroid 5α-oxidoreductase