A convenient protocol for selective cleavage of 2-hydroxy acid amides. Application to semisynthesis of the cyclic heptapeptide Aza HUN-7293

Journal of Organic Chemistry

Volumn 67, Issue 24, 2002, Pages 8299-8304

  Schreiner, Erwin P ^a   Kern, Michael ^a   Steck, Andrea ^a  

^a Brunnerstra e 59   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOSELECTIVITY;

CELLS; DEGRADATION; ESTERS; SAPONIFICATION;

ORGANIC ACIDS;

1 ETHYLTHIOUREA; 2 (HYDROXYPROPIONYLAMINO) 4 METHYLPENTANOIC ACID METHYL ESTER; 2 HYDROXYACID; AMIDE; CYCLOPEPTIDE; DEPSIPEPTIDE; GLUTAMATE SODIUM; HEPTAPEPTIDE; HUN 7293; INTERCELLULAR ADHESION MOLECULE 1; METHYL DEXTRO DEHYDROGLUTAMINATE; PROTEIN INHIBITOR; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE; VASCULAR CELL ADHESION MOLECULE 1; HYDROXYACID;

ARTICLE; BINDING AFFINITY; CELL ADHESION; CHEMICAL BINDING; DEGRADATION; DNA CLEAVAGE; INHIBITION KINETICS; METHODOLOGY; METHYLATION; MOLECULAR MODEL; PEPTIDE SYNTHESIS; POINT MUTATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; SAPONIFICATION; TRANSESTERIFICATION; AMINO ACID SEQUENCE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPARATIVE STUDY; CYCLIZATION; DRUG EFFECT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMIDES; AMINO ACID SEQUENCE; CATALYSIS; CELL ADHESION; COMBINATORIAL CHEMISTRY TECHNIQUES; CYCLIZATION; HYDROXY ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; METHYLATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037195741     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo025979g     Document Type: Article

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