Exclusion of the lim homeodomain gene LHX4 as a candidate gene for pituitary dwarfism in German shepherd dogs

Molecular and Cellular Endocrinology

Volumn 197, Issue 1-2, 2002, Pages 57-62

  Van Oost, B A ^a   Versteeg, S A ^a   Imholz, S ^a   Kooistra, H S ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

BAC; CA repeat; Dog; Dwarfism; LHX4; Pituitary

Indexed keywords

DNA MARKER; HOMEODOMAIN PROTEIN; LHX4 PROTEIN, HUMAN; MICROSATELLITE DNA; TRANSCRIPTION FACTOR;

ANIMAL GENETICS; ANIMAL MODEL; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CHROMOSOME ISOLATION; CONTROLLED STUDY; DOG; DOG DISEASE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; INHERITANCE; MOLECULAR CLONING; NONHUMAN; PHENOTYPE; PITUITARY DWARFISM; PRIORITY JOURNAL; SOUTHERN BLOTTING; ANIMAL; ANIMAL DISEASE; FEMALE; GENETIC LINKAGE; GENETICS; HUMAN; MALE; METABOLISM; PEDIGREE;

ANIMALS; CHROMOSOMES, ARTIFICIAL, BACTERIAL; DOG DISEASES; DOGS; DWARFISM, PITUITARY; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; LINKAGE (GENETICS); MALE; MICROSATELLITE REPEATS; PEDIGREE; TRANSCRIPTION FACTORS;

EID: 0037195518     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(02)00292-7     Document Type: Article

References (23)

1. Andresen E., Willeberg P. Pituitary dwarfism in German shepherd dogs: additional evidence of simple, autosomal recessive inheritance. Nord. Vet. Med. 28:1976;481-486.
2. Cai W.-W., Reneker J., Chow C.-W., Vaishnav M., Bradley A. An anchored framework BAC map of mouse chromosome 11 assembled using multiplex oligonucleotide hybridization. Genomics. 54:1998;387-397.
3. Cushman L.J., Camper S.A. Molecular basis of pituitary dysfunction in mouse and human. Mamm. Genome. 12:2001;485-494.
4. Everts R.E., Versteeg S.A., Renier C., Vignaux F., Groot P.C., Rothuizen J., van Oost B.A. Isolation of DNA markers informative in purebred dog families by genomic representational difference analysis (gRDA). Mamm. Genome. 11:2000;741-747.
5. Flück, C., Deladoey, J., Rutishauser, K., Eble, A., Marti, U., Wu, W., Mullis, P.E., 1998. Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg→Cys at codon 120 (R120C). J. Clin. Endocrinol. Metab. 83, 3727-3734.
6. Groot P.C., van Oost B.A. Identification of fragments of human transcripts from a defined chromosomal region: representational difference analysis of somatic cell hybrids. Nucleic Acids Res. 26:1998;4476-4481.
7. Hamann F., Kooistra H.S., Mol J.A., Gottschalk S., Bartels T., Rijnberk A. Pituitary function and morphology in two German shepherd dogs with congenital dwarfism. Vet. Rec. 144:1999;644-646.
8. Hobert O., Westphal H. Functions of LIM-homeobox genes. Trends Genet. 16:2000;75-83.
9. Kooistra H.S., Voorhout G., Selman P.J., Rijnberk A. Progestin-induced growth hormone (GH) production in the treatment of dogs with congenital GH deficiency. Domest. Anim. Endocrinol. 15:1998;93-102.
10. Kooistra H.S., Voorhout G., Mol J.A., Rijnberk A. Combined pituitary hormone deficiency in German shepherd dogs with dwarfism. Domest. Anim. Endocrinol. 19:2000;177-190.
11. Korstanje R., Gillissen G.F., den Bieman M.G., Versteeg S.A., van Oost B.A., Fox R.R., van Lith H.A., van Zutphen L.F.M. Mapping of rabbit chromosome 1 markers generated from a microsatellite enriched chromosome-specific library. Anim. Genet. 32:2001;308-312.
12. Lantinga-van Leeuwen I.S., Mol J.A., Kooistra H.S., Rijnberk A., Breen M., Renier C., Van Oost B.A. Cloning of the canine gene encoding transcription factor Pit-1 and its exclusion as candidate gene in a canine model of pituitary dwarfism. Mamm. Genome. 11:2000;31-36.
13. Lantinga-van Leeuwen I.S., Kooistra H.S., Mol J.A., Renier C., Breen M., Van Oost B.A. Cloning, characterization, and physical mapping of the canine Prop-1 gene (Prop1): exclusion as a candidate gene for combined pituitary hormone deficiency in German shepherd dogs. Cytogenet. Cell Genet. 88:2000;140-144.
14. Li S., Crenshaw E.B. III, Rawson E.J., Simmons D.M., Swansonm L.W., Rosenfeld M.G. Dwarf locus mutants lacking three pituitary cell types results from mutations in the POU-domain gene Pit-1. Nature. 347:1990;528-533.
15. Li R., Mignot E., Faraco J., Kadotani H., Cantanese J., Zhao B., Lin X., Hinton L., Ostrander E.A., Patterson D.F., de Jong P.J. Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library. Genomics. 58:1999;9-17.
16. Machinis K., Pantel J., Netchine I., Leger J., Camand O.J., Sobrier M.L., Dastot-Le Moal F., Duquesnoy P., Abitbol M., Czernichow P., Amselem S. Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4. Am. J. Hum. Genet. 69:2001;961-968.
17. Miller S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1988;1215.
18. Rieger M., Schwarz H.P., Turecek P.L., Dorner F., van Mourik J.A., Mannnhalter C. Identification of mutations in the canine von Willebrand factor gene associated with type III von Willebrand disease. Thromb. Haemost. 80:1998;332-337.
19. Sornson M.W., Wu W., Dasen J.S., Flynn S.E., Norman D.J., O'Connell S.M., Gukovsky I., Carrière C., Ryan A.K., Miller A.P., Zuo L., Gleiberman A.S., Andersen B., Beamer W.G., Rosenfeld M.G. Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature. 384:1996;327-333.
20. Van de Sluis B.J., Breen M., Nanji M., van Wolferen M., de Jong P., Binns M.M., Pearson P.L., Kuipers J., Rothuizen J., Cox D.W., Wijmenga C., van Oost B.A. Genetic mapping of the copper toxicosis locus in Bedlington terriers to dog chromosome 10, in a region syntenic to human chromosome region 2p13-p16. Hum. Mol. Genet. 8:1999;501-507.
21. Van de Sluis B.J., Rothuizen J., Pearson P.L., van Oost B.A., Wijmenga C. Identification of a new copper metabolism gene by positional cloning in a purebred dog population. Hum. Mol. Genet. 11:2002;165-173.
22. Venta P.J., Yuzbasiyan V., Brewer G.J., Schall W.D. Mutation causing von Willebrand's disease in Scottish Terriers. J. Vet. Int. Med. 14:2000;10-19.
23. Watkins-Chow D.E., Camper S.A. How many homeobox gens does it take to make a pituitary gland? Trends Genet. 14:1998;284-290.