Locally produced growth hormone in canine insulinomas

Molecular and Cellular Endocrinology

Volumn 197, Issue 1-2, 2002, Pages 187-195

  Robben, J H ^a   Van Garderen, E ^b   Mol, J A ^a   Wolfswinkel, J ^a   Rijnberk, A ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Canine; Dog; Growth hormone; Insulinoma; Pancreatic endocrine tumour

Indexed keywords

COMPLEMENTARY DNA; DIGOXIGENIN; GROWTH HORMONE; MESSENGER RNA; PHOSPHORUS; SOMATOSTATIN; INSULIN;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CONTROLLED STUDY; DNA PROBE; DOG; FEMALE; GENE EXPRESSION; HORMONE RELEASE; HYBRID; IMAGING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INSULINOMA; MALE; METASTASIS; NONHUMAN; PANCREAS; PARACRINE SIGNALING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; STAINING; TUMOR; TUMOR CELL; TUMOR GROWTH; ANIMAL; ANIMAL DISEASE; DOG DISEASE; GENETICS; LIVER TUMOR; METABOLISM; PANCREAS TUMOR; PATHOLOGY;

ANIMALS; DOG DISEASES; DOGS; FEMALE; GROWTH HORMONE; IN SITU HYBRIDIZATION; INSULIN; INSULINOMA; LIVER NEOPLASMS; MALE; PANCREATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0037195513     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(02)00268-X     Document Type: Article

References (45)

1. Ben-Jonathan N., Mershon J.L., Allen D.L., Steinmetz R.W. Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects. Endocr. Rev. 17:1996;639-669.
2. Billestrup N. Human growth hormone binding and stimulation of insulin biosynthesis in cloned rat insulinoma cells. Biomed. Biochem. 44:1985;85-87.
3. Billestrup N., Martin J.M. Growth hormone binding to specific receptors stimulates growth and function of cloned insulin-producing rat insulinoma RIN-5AH cells. Endocrinology. 116:1985;1175-1181.
4. Billestrup N., Nielsen J.H. The stimulatory effect of growth hormone, prolactin, and placental lactogen on β-cell proliferation is not mediated by insulin-like growth factor-1. Endocrinology. 129:1991;883-888.
5. Billestrup N., Møldrup A., Serup P., Mathews L.S., Norstedt G., Nielsen J.H. Introduction of exogenous growth hormone receptors augments growth hormone-responsive insulin biosynthesis in rat insulinoma cells. Proc. Natl. Acad. Sci. 87:1990;7210-7214.
6. Brelje T.C., Sorenson R.L. The physiological roles of prolactin, growth hormone and placental lactogen in the regulation of islet β-cell proliferation. Sarvetnick N., Tissue Engineering: Pancreatic Growth and Regeneration. 1997;1-30 Karger Landes Systems, Basel.
7. Brelje T.C., Scharp D.W., Lacey P.E., Ogren L., Talamantes F., Robertson M., Friesen H.G., Sorenson R.L. Effect of homologous placental lactogens, prolactins, and growth hormones on islet ß-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy. Endocrinology. 132:1993;879-887.
8. Buscail L., Saint-Laurant N., Chastre E., Vaillant J.-C., Gespach C., Capellà G., Kalthoff H., Lluis F., Vaysse N., Susini C. Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal cancer. Cancer Res. 56:1996;1823-1827.
9. Carlsson C., Tornehave D., Lindberg K., Galante P., Billestrup N., Michelsen B., Larsson L.I., Nielsen J.H. Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas. Endocrinology. 138:1997;3940-3948.
10. Clark R. The somatogenic hormones and insulin-like growth factor-1: stimulators of lymphopoiesis and immune function. Endocr. Rev. 18:1997;157-179.
11. Davidson M.B. Effect of growth hormone on carbohydrate and lipid metabolism. Endocr. Rev. 8:1987;115-131.
12. Dayal Y., Lin H.D., Tallberg K., Reichlin S., DeLellis R.A., Wolfe H.J. Immunocytochemical demonstration of growth hormone-releasing factor in gastrointestinal and pancreatic endocrine tumors. Am. J. Clin. Pathol. 85:1986;13-20.
13. Delesque N., Buscail L., Estève J.-P., Saint-Laurant N., Müller C., Weckbecker G., Bruns C., Vaysse N., Susini C. sst2 somatostatin receptor expression reverses tumorigenicity of human pancreatic cancer cells. Cancer Res. 57:1997;956-962.
14. Doglioni C., Gambacorta M., Zamboni G., Coggi G., Viale G. Immunocytochemical localization of progesterone receptors in endocrine cells of the human pancreas. Am. J. Pathol. 137:1990;999-1005.
15. Dunn J.K., Heath M.F., Herrtage M.E., Jackson K.F., Walker M.J. Diagnosis of insulinoma in the dog: a study in 11 cases. J. Small Anim. Pract. 33:1992;514-520.
16. Eigenmann J.E., Eigenmann R.Y. Radioimmunoassay of canine growth hormone. Acta Endocrinol. 98:1981;514-520.
17. Hawkins K.L., Summers B.A., Kuhajda T.P., Smith C.A. Immunohistochemistry of normal pancreatic islets and spontaneous islet cell tumors in dogs. Vet. Pathol. 24:1987;170-179.
18. Heitz P.U., Kasper M., Polak J.M., Klöppel G. Pancreatic endocrine tumors: Immunocytochemical analysis of 125 tumors. Hum. Pathol. 13:1982;263-271.
19. Heitz P.U., Klöppel G., Polak J.M., Staub J.J. Ectopic hormone production by endocrine tumors: localization of hormones at the cellular level by immunocytochemistry. Cancer. 48:1981;2029-2037.
20. Kooijman R., Berus D., Malur A., Delhase M., Hooghe-Peeters E.L. Human neutrophils express GH-N gene transcripts and the pituitary transcription factor Pit-1b. Endocrinology. 138:1997;4481-4484.
21. Kooijman R., Malur A., Van Buul-Offers S.C., Hooghe-Peters E.L. Growth hormone expression in murine bone marrow cells is independent of the pituitary transcription factor Pit-1. Endocrinology. 138:1997;3949-3955.
22. Lantinga-Van Leeuwen I.S., Oudshoorn M., Mol J.A. Canine mammary growth hormone gene transcription initiates at the pituitary-specific start site in the absence of Pit-1. Mol. Cell. Endocrinol. 150:1999;121-128.
23. Melmed S., Ezrin C., Kovacs K., Goodman R.S., Frohman L.A. Acromegaly due to secretion of growth hormone by an ectopic pancreatic islet-cell tumor. New Engl. J. Med. 312:1985;9-17.
24. Mol J.A., Henzen-Logmans S.C., Hageman Ph., Misdorp W., Blankenstein M.A., Rijnberk A. Expression of the gene encoding growth hormone in the human mammary gland. J. Clin. Endocrinol. Metab. 80:1995;3094-3096.
25. Mol J.A., Van Garderen E., Selman P.J., Wolfswinkel J., Rijnberk A., Rutteman G.R. Growth hormone mRNA in mammary gland tumors of dogs and cats. J. Clin. Invest. 95:1995;2028-2034.
26. Mol J.A., Van Garderen E., Rutteman G.R., Rijnberk A. New insights in the molecular mechanism of progestin-induced proliferation of mammary epithelium: induction of the local biosynthesis of growth hormone (GH) in the mammary gland of dogs, cats and humans. J. Steroid. Biochem. Molec. Biol. 57:1996;67-71.
27. Møldrup A., Billestrup N., Nielsen J.H. Rat insulinoma cells express both a 115-kDa growth hormone receptor and a 95-kDa prolactin receptor structurally related to the hepatic receptors. J. Biol. Chem. 265:1990;8686-8690.
28. Nielsen J.H., Lernmark Å., Madsen O.D., Welinder B.S., Linde S., Billestrup N., Møldrup A. Effects of growth hormone on the endocrine pancreas. Isaksson O., Binder C.H.K., Hökfelt B., Proceedings of the 1st Nordisk Insulin Symposium 'Growth Hormone: Basic and Clinical Aspects'. 1987;227-237 Elsevier Science Publishers, Amsterdam.
29. Nielsen J.H., Linde S., Welinder B.S., Billestrup N., Madsen O.D. Growth hormone is a growth factor for the differentiated pancreatic β-cell. Mol. Endocrinol. 3:1989;165-173.
30. Nielsen J.H., Møldrup A., Billestrup N., Petersen E.D., Allevato G., Stahl M. The role of growth hormone and prolactin in beta cell growth and regeneration. Vinik A.I., Advances in Experimental Medicine and Biology. 321:1992;9-17 Plenum Press, New York.
31. Nieuwenhuizen A.G., Schuiling G.A., Hilbrands L.G., Bisschop E.M., Moes H., Koiter T.R. Proliferation of pancreatic islet cells in cyclic and pregnant rats after treatment with progesterone. Horm. Metab. Res. 30:1998;649-655.
32. O'Brien T.P., Hayden D.W., O'Leary T.P., Caywood D.D., Johnson K.H. Canine pancreatic endocrine tumors: immunohistochemical analysis of hormone content and amyloid. Vet. Pathol. 24:1987;308-314.
33. Otto P., 1992. Untersuchungen an Hunden mit Inselzelltumoren: Immunhistochemische Darstellung von Hormonen in den Tumorzellen; Vergleich mit der Insulin- und Glucosekonzentration im Patientenserum. Thesis. Berlin, pp. 77-85.
34. Petrusz P., Merchenthaler I., Ordronneau P., Maderdrut J.L., Vigh S., Schally A.V. Corticotropin-releasing factor (CRF)-like immunoreactivity in the gastro-entero-pancreatic endocrine system. Peptides. 5:1984;71-78.
35. Render C.L., Hull K.L., Harvey S. Neural expression of the pituitary GH gene. J. Endocrinol. 147:1995;413-422.
36. Robben J.H., Visser-Wisselaar H.A., Rutteman G.R., Van Rijk P.P., Van Dongen A.J., Voorhout G., Van Den Ingh Th.S.G.A.M., Hofland L.J., Lamberts S.W.J. In vitro and in vivo detection of functional somatostatin receptors in canine insulinomas. J. Nucl. Med. 38:1997;1036-1042.
37. Selman P.J., Mol J.A., Rutteman G.R., Van Garderen E., Rijnberk A. Progestin-induced growth hormone excess in the dog originates in the mammary gland. Endocrinology. 134:1994;287-292.
38. Sekine N., Wollheim C.B., Fujita T. GH signalling in pancreatic β-cells. Endocr. J. 45:1998;S33-S40.
39. Service F.J., McMahon M.M., O'Brien P.C., Ballard D.J. Functioning insulinoma - incidence, recurrence, and long-term survival of patients: a 60-year study. Mayo Clin. Proc. 66:1991;711-719.
40. Stefanini P., Carboni M., Patrassi N., Basoli A. Beta-cell tumors of the pancreas: results of a study on 1067 cases. Surgery. 75:1974;597-609.
41. Sundler F., Alumets J., Hakanson R. Growth hormone-like immunoreactivity in gastrin cells and gastrinomas. Histochemistry. 59:1979;343-346.
42. Untergasser G., Kranewitter W., Schwärzler P., Madersbacher S., Dirnhofer S., Berger P. Organ-specific expression pattern of the human growth hormone/placental lactogen gene-cluster in the testis. Mol. Cell. Endocrinol. 130:1997;53-60.
43. Van Buul-Offers S.C., Kooijman R. The role of growth hormone and insulin-like growth factors in the immune system. Cell. Mol. Life Sci. 54:1998;1083-1094.
44. Van Garderen E., De Wit M., Voorhout W.F., Rutteman G.R., Mol J.A., Nederbragt H., Misdorp W. Expression of growth hormone in canine mammary tissue and mammary tumors. Evidence for a potential autocrine/paracrine stimulatory loop. Am. J. Pathol. 150:1997;1037-1047.
45. Viale G., Doglioni C., Gambacorta M., Zamboni G., Coggi G., Bordi C. Progesterone receptor immunoreactivity in pancreatic endocrine tumors. An immunocytochemical study of 156 neuroendocrine tumors of the pancreas, gastrointestinal and respiratory tracts, and skin. Cancer. 70:1992;2268-2277.