A newton-based approach for attributing tumor lethality in animal carcinogenicity studies

Computational Statistics and Data Analysis

Volumn 38, Issue 3, 2002, Pages 263-283

  Ahn, Hongshik ^a   Moon, Hojin ^b   Kim, Sunyoung ^c   Kodell, Ralph L ^d  

^a Stony Brook University   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c Ewha Womans University   (South Korea)

^d NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Cause of death; Inequality constraint; Maximum likelihood; Optimization; Sacrifice

Indexed keywords

CARCINOGENS; COMPUTATIONAL METHODS; COMPUTER SIMULATION; CONSTRAINT THEORY; MAXIMUM LIKELIHOOD ESTIMATION; MONTE CARLO METHODS; TUMORS;

NONLINEAR FUNCTIONS;

STATISTICAL METHODS;

CANCER; STATISTICAL ANALYSIS;

EID: 0037185750     PISSN: 01679473     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-9473(01)00041-X     Document Type: Article

References (12)

1. Attribution of tumor lethality and estimation of time to onset of occult tumors in the absence of cause-of-death information
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3. Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples
4. A new method of constrained optimization and a comparison with other methods
5. A class of methods for solving nonlinear simultaneous equations
6. Influence of cause-of-death assignment on time-to-tumor analyses in animal carcinogenesis studies
7. On the representativeness assumption in prevalence tests of carcinogenicity
8. Effects of dose and time in a long-term, low-dose carcinogenic study
9. Age-specific models of mortality and tumor onset for control animals in the national toxicology program's carcinogenicity experiments