Substantial equivalence - An appropriate paradigm for the safety assessment of genetically modified foods?

Toxicology

Volumn 181-182, Issue , 2002, Pages 427-431

  Kuiper, Harry A ^a   Kleter, Gijs A ^a   Noteborn, Hub P J M ^a   Kok, Esther J ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Concept of substantial equivalence; Genetically modified crops; Safety evaluation

Indexed keywords

PROTEIN;

BIOCHEMISTRY; CELL METABOLISM; DNA MODIFICATION; GENE EXPRESSION; GENETICALLY MODIFIED FOOD; GENOME; HUMAN; IMMUNOTOXICITY; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT;

APOGON BRACHYGRAMMUS;

EID: 0037184861     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00488-2     Document Type: Article

References (17)

1. Essers A.J.A., Alink G.M., Speijers G.J.A., Alexander J., Bouwmeister P.-J., van den Brandt P.A., Ciere S., Gry J., Herrman J., Kuiper H.A., Mortby E., Renwick A.G., Shrimpton D.H., Vainio H., Vitozzi L., Koeman J.H. Food plant toxicants and safety, risk assessment and regulation of inherent toxicants in plant foods. Environ. Toxicol. Pharmacol. 5:1998;155-172.
2. FAO/WHO, 2000. Safety Aspects of Genetically Modified Foods of Plant Origin. Report of a Joint FAO/WHO Expert Consultation on Foods Derived from Biotechnology, Geneva, Switzerland, 29 May-2 June 2000. Food and Agriculture Organisation of the United Nations, Rome. http://www.fao.org/es/esn/gm/biotec-e.htm.
3. FAO/WHO, 2001. Allergenicity of Genetically Modified Foods, Joint FAO/WHO Expert Consultation on Foods Derived from Biotechnology, Rome, 22-25 January 2001. Food and Agriculture Organisation of the United Nations, Rome. http://www.fao.org/es/esn/gm/biotec-e.htm.
4. Hashimoto W., Momma K., Yoon H.-J., Ozawa S., Ohkawa Y., Ishige T., Kito M., Utsumi S., Murata K. Safety assessment of transgenic potatoes with soybean glycinin by feeding studies in rats. Biosci. Biotechnol. Biochem. 63:1999;1942-1946.
5. Hattan, D., 1996. Evaluation of toxicological studies on Flavr Savr tomato. pp. 58-60 in OECD (1996).
6. Kuiper, H.A., 2000. Profiling Techniques to Identify Differences between Foods Derived from Biotechnology and their Counterparts. Document on topic 5 in FAO/WHO (2000).
7. Kuiper H.A., Kleter G.A., Noteborn H.P.J.M., Kok E.J. Assessment of the food safety issues related to genetically modified foods. Plant J. 27:2001;508-528. http://www.blackwell-science.com/products/journals/plantGM/tpj1119.pdf.
8. Millstone E., Brunner E., Mayer S. Beyond 'substantial equivalence'. Nature. 401:1999;525-526.
9. Noteborn, H.P.J.M., Bienenmann-Ploum, M.E., van den Berg, J.H.J., Alink, G.M., Zolla, L., Reynaerts, A., Pensa, M., Kuiper, H.A., 1995. Safety assessment of the Bacillus thuringiensis insecticidal crystal protein CRYIA(b) expressed in transgenic tomatoes. In: Engel, K.-H., Takeoka, G.R., Teranishi, R. (Eds.), Genetically Modified Foods - Safety Aspects, ACS Symposium Series 605, American Chemical Society, Washington DC, pp. 134-147.
10. Noteborn H.P.J.M., Lommen A., Van der Jagt R.C., Weseman J.M. Chemical fingerprinting for the evaluation of unintended secondary metabolic changes in transgenic food crops. J. Biotechnol. 77:2000;103-114.
11. OECD, 1993a. Safety Evaluation of Foods Derived by Modern Biotechnology: Concept and Principles, Organisation for Economic Co-operation and Development, Paris. http://www.oecd.org/pdf/M00032000/M00032672.pdf.
12. OECD, 1993b. OECD Guidelines for the Testing of Chemicals, Organisation for Economic Co-operation and Development, Paris.
13. OECD, 1996. Food Safety Evaluation, Organisation for Economic Co-operation and Development, Paris.
14. OECD, 1998. Report of the OECD Workshop on the Toxicological and Nutritional Testing of Novel Foods, Aussois, France, 5-8 March, 1997. Organisation for Economic Co-operation and Development, Paris. http://www.olis.oecd.org/olis/1998doc.nsf/LinkTo/sg-icgb(98)1-final.
15. OECD, 2001. Consensus Documents, Organisation for Economic Co-operation and Development, Inter-Agency Network for Safety in Biotechnology, Paris. http://www.oecd.org/oecd/pages/home/displaygeneral/0,3380,EN-document-530- nodirectorate-no-27-24778-32,00.html.
16. Schena M., Shalon D., Davis R.W., Brown P.O. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science. 270:1995;467-470.
17. Van Hal N.L.W., Vorst O., Van Houwelingen A.M.M.L., Kok E.J., Peijnenburg A., Aharoni A., Van Tunen A.J., Keijer J. The application of DNA microarrays in gene expression analysis. J. Biotechnol. 78:2000;271-280.