Synthesis of C-3′ methyl taxotere (docetaxel)

Journal of Organic Chemistry

Volumn 67, Issue 26, 2002, Pages 9468-9470

  Lucatelli, Christophe ^a   Viton, Florian ^a   Gimbert, Yves ^a   Greene, Andrew E ^a  

^a UNIVERSITÉ JOSEPH FOURIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PROTECTING GROUPS;

ESTERIFICATION; SYNTHESIS (CHEMICAL);

ORGANIC COMPOUNDS;

C 3' METHYLTAXOTERE; DOCETAXEL; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ESTERIFICATION; PROTECTION; STEREOCHEMISTRY;

COMBINATORIAL CHEMISTRY TECHNIQUES; ESTERIFICATION; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PACLITAXEL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TAXOIDS;

EID: 0037184831     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo026460n     Document Type: Article

References (31)

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27. In THF, the ratio was higher, but the yield was considerably lower (83:17, 43%). Solvent effects on the ratio of diastereomers in the Staudinger reaction have previous been noted. See, for example, ref 7a.
28. 3, F(000) = 752, θ range 2.10-72°, 2229 measured reflections, 2229 independent reflections, R(1) [I > 1.5σ] = 0.044, wR2 [all data] = 0.0468, GoF (all data) = 1.887.
29. 3, F(000) = 332, θ range 2.63-30° 10 043 measured reflections, 4544 [R(int) = 0.09] independent reflections, R(1) [I > 3σ] = 0.0496, wR2 [all data] = 0.0664, GoF (all data) = 1.903.
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