Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: A randomized controlled trial

JAMA

Volumn 288, Issue 20, 2002, Pages 2561-2568

  Randolph, Adrienne G ^a,b   Wypij, David ^a,c   Venkataraman, Shekhar T ^d   Hanson, James H ^e   Gedeit, Rainer G ^f   Meert, Kathleen L ^g   Luckett, Peter M ^h   Forbes, Peter ^a   Lilley, Michelle ^a   Thompson, John ^a   Cheifetz, Ira M ⁱ   Hibberd, Patricia ^a   Wetzel, Randall ^j   Cox, Peter N ^k   Arnold, John H ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^e CHILDREN S HOSPITAL OAKLAND   (United States)

^f CHILDREN S HOSPITAL OF WISCONSIN   (United States)

^g CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

^h CHILDREN S MEDICAL CENTER   (United States)

ⁱ DUKE CHILDREN S HOSPITAL   (United States)

^j CHILDREN S HOSPITAL LOS ANGELES   (United States)

^k HOSPITAL FOR SICK CHILDREN   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ARTIFICIAL VENTILATION; AUTOMATION; CHILD; CHILD CARE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; INFANT; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTCOMES RESEARCH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT FAILURE; WEANING;

EID: 0037184417     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.288.20.2561     Document Type: Article

References (25)

1. Randolph AG. Weaning from mechanical ventilation. New Horiz. 1999;7:374-385.
2. Harris TR, Wood BR. Physiologic principles. In: Karotkin EH, Goldsmith JP, eds. Assisted Ventilation of the Neonate. Philadelphia, Pa: WB Saunders & Co; 1996:29-31.
3. Woodruff DW. How to ward off complications of mechanical ventilation. Nursing. 1999;29:34-39.
4. Tobias JD, Deshpande JK, Gregory DF. Outpatient therapy of iatrogenic drug dependency following prolonged sedation in the pediatric intensive care unit. Intensive Care Med. 1994;20:504-507.
5. MacIntyre NR, Cook DJ, Ely EW Jr, et al. Evidence-based guidelines for weaning and discontinuing ventilatory support. Chest. 2001;120(suppl 6):375S-395S.
6. Kollef MH, Shapiro SD, Silver P, et al. A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation. Crit Care Med. 1997;25:567-574.
7. Brochard L, Pluskwa F, Lemaire F. Improved efficacy of spontaneous breathing with inspiratory pressure support. Am Rev Respir Dis 1987;136:411-415.
8. Brochard L, Rua F, Lorino H, Lemaire F, Harf A. Inspiratory pressure support compensates for the additional work of breathing caused by the endotracheal tube. Anesthesiology. 1991;75:739-745.
9. Martin LD. New approaches to ventilation in infants and children. Curr Opin Pediatr. 1995;7:250-261.
10. Pollack MM, Patel KM, Ruttimann UE. PRISM III: An updated Pediatric Risk of Mortality score. Crit Care Med. 1996;24:743-752.
11. Bock KR, Silver P, Rom M, Sagy M. Reduction in tracheal lumen due to endotracheal intubation and its calculated clinical significance. Chest. 2000;118:468-472.
12. Hamill PV, Drizd TA, Johnson CL, Reed RB, Roche AF. NCHS growth curves for children birth-18 years: United States. Vital Health Stat 11. 1977;165:i-iv, 1-74.
13. Wilson WC, Smedira NG, Fink C, McDowell JA, Luce JM. Ordering and administration of sedatives and analgesics during the withholding and withdrawal of life support from critically ill patients. JAMA. 1992;267:949-953.
14. Brochard L, Rauss A, Benito S, et al. Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med. 1994;150:896-903.
15. Esteban A, Frutos F, Tobin MJ, et al, for the Spanish Lung Failure Collaborative Group. A comparison of four methods of weaning patients from mechanical ventilation. N Engl J Med. 1995;332:345-350.
16. Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342:1471-1477.
17. Lauterbach MD, Raz S, Sander CJ. Neonatal hypoxic risk in preterm birth infants. Neuropsychology. 2001;15:411-420.
18. Fine MJ, Smith MA, Carson CA, et al. Prognosis and outcomes of patients with community-acquired pneumonia: A meta-analysis. JAMA. 1996;275:134-141.
19. Schultz TR, Lin RJ, Watzman HM, et al. Weaning children from mechanical ventilation. Respir Care. 2001;46:772-782.
20. Esteban A, Alia I, Gordo F, et al, for the Spanish Lung Failure Collaborative Group. Extubation outcome after spontaneous breathing trials with T-tube or pressure support ventilation. Am J Respir Crit Care Med. 1997;156:459-465.
21. Ely EW, Baker AM, Dunagan DP, et al. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med. 1996;335:1864-1869.
22. el Khatib MF, Baumeister B, Smith PG, Chatburn RL, Blumer JL. Inspiratory pressure/maximal inspiratory pressure. Intensive Care Med. 1996;22:264-268.
23. Khan N, Brown A, Venkataraman ST. Predictors of extubation success and failure in mechanically ventilated infants and children. Crit Care Med. 1996;24:1568-1579.
24. Thiagarajan RR, Bratton SL, Martin LD, Brogan TV, Taylor D. Predictors of successful extubation in children. Am J Respir Crit Care Med. 1999;160:1562-1566.
25. Tobias JD. Subcutaneous administration of fentanyl and midazolam to prevent withdrawal after prolonged sedation in children. Crit Care Med. 1999;27:2262-2265.