Continuous purification of a clotting factor IX concentrate and continuous regeneration by preparative annular chromatography

Journal of Chromatography A

Volumn 972, Issue 1, 2002, Pages 115-129

  Iberer, Günter ^a,b   Schwinn, Horst ^a   Josic, Djuro ^a   Jungbauer, Alois ^b   Buchacher, Andrea ^a  

^a Octapharma Pharmazeutika Produktions GmbH   (Austria)

^b UNIVERSITY OF AGRICULTURAL SCIENCES   (Austria)

Author keywords

Continuous annular chromatography; Factor IX; Preparative chromatography; Proteins; Vitronectin

Indexed keywords

BATCH DATA PROCESSING; CHROMATOGRAPHIC ANALYSIS; IMPURITIES; PROTEINS; SEPARATION;

ANNULAR CHROMATOGRAPHY; CLOTTING; ELUTION;

PURIFICATION;

2 DIETHYLAMINOETHANOL; BLOOD CLOTTING FACTOR 9 CONCENTRATE; SORBENT; VITRONECTIN;

ARTICLE; BATCH PROCESS; CHROMATOGRAPHY; DEVICE; ELUTION; EXPERIMENTAL MODEL; FLOW RATE; INDUSTRY; INTERMETHOD COMPARISON; METHODOLOGY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PRODUCTIVITY; PROTEIN PURIFICATION; SEPARATION TECHNIQUE;

BLOTTING, WESTERN; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, ION EXCHANGE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FACTOR IX; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0037183735     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(02)01074-9     Document Type: Article

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