Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: Implications for diazoaminobenzene carcinogenicity

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 521, Issue 1-2, 2002, Pages 201-208

  Ress, Nancy B ^a   Witt, Kristine L ^b   Xu, Jing ^c   Haseman, Joseph K ^a   Bucher, John R ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b ILS Inc   (United States)

^c SITEK Research Laboratories   (United States)

Author keywords

Bone marrow; Carcinogenicity; Chromosome damage; Erythrocyte; Mixtures

Indexed keywords

ANILINE; BENZENE; BENZENE DERIVATIVE; CORN OIL; DIAZOAMINOBENZENE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CARCINOGENICITY; CHROMOSOME DAMAGE; CONTROLLED STUDY; ERYTHROCYTE; FEEDING; GENOTOXICITY; MALE; METABOLITE; MICRONUCLEUS; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANILINE COMPOUNDS; ANIMALS; BENZENE; BONE MARROW; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; MICE, INBRED STRAINS; MICRONUCLEUS TESTS; TRIAZENES;

RODENTIA; SALMONELLA; ZEA MAYS;

EID: 0037180361     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(02)00241-3     Document Type: Article

References (30)

1. R.J. Lewis Sr., Hawley's Condensed Chemical Dictionary, 12th Ed., Van Nostrand Reinhold Co., NY, 1993, p. 366.
2. Bailey J.E. Jr. Determination of 1,3-diphenyltriazene and azobenzene in D&C Red No. 33 by solvent extraction and reversed-phase high-performance liquid chromatography. J. Chromatogr. 321:1985;185-197.
3. Palmer S., Mathews R.A. The role of non-nutritive dietary constituents in carcinogenesis. Surg. Clin. North Am. 66:1986;891-915.
4. Kadiiska M.B., De Costa K.S., Mason R.P., Mathews J.M. Reduction of 1,3-diphenyl-1-triazene by rat hepatic microsomes, by cecal microflora, and in rats generates the phenyl radical metabolite: an ESR spin-trapping investigation. Chem. Res. Toxicol. 13:2000;1082-1086.
5. Mathews J.M., De Costa K.S. Absorption, metabolism, and disposition of 1,3-diphenyl-1-triazene in rats and mice after oral, i.v., and dermal administration. Drug Metab. Dispos. 27:1999;1499-1504.
6. 1 Mice (Gavage Studies), Technical Report Series No. 289, NIH Publication No. 86-2545, US Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC, 1986.
7. Kahn M.F., Wu X., Kaphalia B.S., Boor P.J., Ansari G.A.S. Acute hematopoietic toxicity of aniline in rats. Toxicol. Lett. 92:1997;31-37.
8. Short C.R., King C., Sistrunk P.W., Kerr K.M. Subacute toxicity of several ring-substituted dialkylanilines in the rat. Fundam. Appl. Toxicol. 3:1983;285-292.
9. National Toxicology Program (NTP), Report on the Metabolism, Toxicity, and Predicted Carcinogenicity of Diazoaminobenzene (CAS# 136-35-6), Toxicity Report Series Number 73, NIH Publication Number 01-4412, US Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC 27709, 2002.
10. 1 mice: retrospective analysis of peripheral blood smears from the NTP carcinogenesis bioassay. Mutat. Res. 143:1985;55-59.
11. MacGregor J.T., Wehr C.M., Henika P.R., Shelby M.D. The in vivo erythrocyte micronucleus test: measurement at steady state increases assay efficiency and permits integration with toxicity studies. Fundam. Appl. Toxicol. 14:1990;513-522.
12. Ashby J., Vlachos D.A., Tinwell H. Activity of aniline in the mouse bone marrow micronucleus assay. Mutat. Res. 263:1991;115-117.
13. Westmoreland C., Gatehouse D.G. Effects of aniline hydrochloride in the mouse bone marrow micronucleus test after oral administration. Carcinogenesis. 12:1991;1057-1059.
14. 1 mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program. Environ. Mol. Mutagen. 36:2000;163-194.
15. Shelby M.D., Erexson G.L., Hook G.J., Tice R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ. Mol. Mutagen. 21:1993;160-179.
16. Hayashi M., Sofuni T., Ishidate M. Jr. An application of acridine orange fluorescent staining to the micronucleus test. Mutat. Res. 120:1983;241-247.
17. ILS, Micronucleus Data Management and Statistical Analysis Software, Version 1.4a, Integrated Laboratory Systems, P.O. Box 13501, Research Triangle Park, NC 27707, 1990.
18. N.L. Johnson, S. Kotz, Discrete Distributions, Houghton Mufflin Company, Boston, 1969, p. 99.
19. Agency for Toxic Substances and Disease Registry (ATSDR), Toxicological Profile for Benzene, US Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC, 1997.
20. Smith T.M., Zhang L., Xi L.-Q. The mechanism of benzene-induced leukemia: a hypothesis and speculations on the causes of leukemia. Environ. Health Perspect. 104:1996;1219-1225.
21. Marcon F., Zijno A., Crebelli R., Carere A., Veidebaum T., Peltonen K., Parks R., Schuler M., Eastmond D. Chromosome damage and aneuploidy detected by interphase multicolour FISH in benzene-exposed shale oil workers. Mutat. Res. 445:1999;155-166.
22. Zhang L., Rothman N., Wang Y., Hayes R.B., Yin S., Titenko-Holland N., Dosemeci M., Wang Y.-Z., Kolachana P., Lu W., Xi L., Li G.-L., Smith M.T. Benzene increases aneuploidy in the lymphocytes of exposed workers: a comparison of data obtained by fluorescence in situ hybridization in interphase and metaphase cells. Environ. Mol. Mutagen. 34:1999;260-268.
23. Kasuba V., Rozgaj R., Sentija K. Cytogenetic changes in subjects occupationally exposed to benzene. Chemosphere. 40:2000;307-310.
24. Shelby M.D., Witt K.L. Comparison of results from mouse bone marrow chromosome aberration and micronucleus test. Environ. Mol. Mutagen. 25:1995;203-313.
25. Tice R.R., Costa D.L., Drew R.T. Cytogenetic effects of inhaled benzene in murine bone marrow: induction of sister chromatid exchanges, chromosomal aberrations, and cellular proliferation inhibition in DBA/2 mice. Proc. Natl. Acad. Sci. U.S.A. 77:1980;2148-2152.
26. Ciranni R., Barale R., Marrazzini A., Loprieno N. Benzene and the genotoxicity of its metabolites. I. Transplacental activity in mouse fetuses and in their dams. Mutat. Res. 208:1988;61-67.
27. Luke C.A., Tice R.R., Drew R.T. The effect of exposure regiment and duration on benzene-induced bone-marrow damage in mice. I. Sex comparison in DBA/2 mice. Mutat. Res. 203:1988;251-271.
28. Suzuki S., Atai H., Hatakeyama Y., Hara M., Nakagawa S. Administration-route-related differences in the micronucleus test with benzene. Mutat. Res. 223:1989;407-410.
29. George E., Andres M., Westmoreland C. Effects of azobenzene and aniline in the rodent bone marrow micronucleus test. Carcinogenesis. 11:1990;1551-1556.
30. Chemical Industry Institute of Toxicology (CIIT), 104-Week Chronic Toxicity Study in Rats: Aniline Hydrochloride, Final Report, Research Triangle Park, NC, 1982.