Determination of methylnaltrexone in clinical samples by solid-phase extraction and high-performance liquid chromatography for a pharmacokinetics study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 780, Issue 2, 2002, Pages 251-259

  Osinski, Joachim ^a,b   Wang, Anbao ^a,b   Wu, Ji An ^a,b   Foss, Joseph F ^a,c,d   Yuan, Chun Su ^a,b,c  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d ADOLOR CORPORATION   (United States)

Author keywords

Electrochemical detection; Methylnaltrexone; Naltrexone

Indexed keywords

ASSAYS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE; METHANOL; PH EFFECTS;

SOLID-PHASE EXTRACTION (SPE);

PHARMACOKINETICS;

17 METHYLNALTREXONE; ACETIC ACID; METHANOL; DRUG DERIVATIVE; NALTREXONE; NARCOTIC ANTAGONIST; QUATERNARY AMMONIUM DERIVATIVE;

ACCURACY; ARTICLE; BLOOD ANALYSIS; CALIBRATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG RETENTION; ELECTROCHEMICAL DETECTION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; URINALYSIS; BLOOD; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; URINE;

CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; NALTREXONE; NARCOTIC ANTAGONISTS; QUATERNARY AMMONIUM COMPOUNDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 0037175419     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(02)00527-5     Document Type: Article

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