The soft metal ion binding sites in the Staphylococcus aureus pI258 CadC Cd(II)Pb(II)/Zn(II)-responsive repressor are formed between subunits of the homodimer

Journal of Biological Chemistry

Volumn 277, Issue 43, 2002, Pages 40930-40936

  Wong, Marco D ^a   Lin, Yung Feng ^a   Rosen, Barry P ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM; CHARGED PARTICLES; LEAD; MONOMERS; PROTEINS;

HOMODIMERIC REPRESSORS;

DIMERS;

4,6 BIS(BROMO METHYL) 3,7 DIMETHYL 1,5 DIAZABICYCLO[3.3.0]OCTA 3,6 DIENE 2,8 DIONE; BROMOBIMANE; CADMIUM; CYSTEINE; GENE PRODUCT; LEAD; METAL ION; PROTEIN CADC; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CROSS LINKING; DIMERIZATION; GENE MUTATION; METAL BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PLASMID; PRIORITY JOURNAL; REGULATORY MECHANISM; REPRESSOR GENE; STAPHYLOCOCCUS AUREUS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; BLOTTING, WESTERN; DIMERIZATION; METALS, HEAVY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 0037174930     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206536200     Document Type: Article

References (37)

1. Nucifora, G., Chu, L., Misra, T. K., and Silver, S. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 3544-3548
2. Endo, G., and Silver, S. (1995) J. Bacteriol. 177, 4437-4441
3. Tsai, K. J., Yoon, K. P., and Lynn, A. R. (1992) J. Bacteriol. 174, 116-121
4. Tsai, K. J., and Linet, A. L. (1993) Arch. Biochem. Biophys. 305, 267-270
5. Busenlehner, L. S., Cosper, N. J., Scott, R. A., Rosen, B. P., Wong, M. D., and Giedroc, D. P. (2001) Biochemistry 40, 4426-4436
6. Sun, Y., Wong, M. D., and Rosen, B. P. (2001) J. Biol. Chem, 276, 14955-14960
7. Xu, C., and Rosen, B. P. (1999) in Metals and Genetics (Sarkar, B., ed) pp. 5-19, Plenum Press, New York
8. San Francisco, M. J., Hope, C. L., Owolabi, J. B., Tisa, L. S., and Rosen, B. P. (1990) Nucleic Acids Res. 18, 619-624
9. Morby, A. P., Turner, J. S., Huckle, J. W., and Robinson, N. J. (1993) Nucleic Acids Res. 21, 921-925
10. Thelwell, C., Robinson, N. J., and Turner-Cavet, J. S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 10728-10733
11. Cook, W. J., Kar, S. R., Taylor, K. B., and Hall, L. M. (1998) J. Mol. Biol. 275, 337-346
12. Sun, Y., Wong, M. D., and Rosen, B. P. (2002) Mol. Microbiol. 44, 1323-1329
13. Busenlehner, L. S., Weng, T. C., Penner-Hahn, J. E., and Giedroc, D. P. (2002) J. Mol. Biol. 319, 685-701
14. Kosower, N. S., Newton, G. L., Kosower, E. M., and Ranney, H. M. (1980) Biochim. Biophys. Acta 622, 201-209
15. Bhattacharjee, H., and Rosen, B. P. (1996) J. Biol. Chem. 271, 24465-24470
16. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, Cold Spring Harbor, NY
17. Poole, R. K., Williams, H. D., Downie, J. A., and Gibson, F. (1989) J. Gen. Microbiol. 135, 1865-1874
18. Chang, A. C., and Cohen, S. N. (1978) J. Bacteriol. 134, 1141-1156
19. Delagrave, S., Hawtin, R. E., Silva, C. M., Yang, M. M., and Youvan, D. C. (1995) Bio/Technology (N. Y.) 13, 151-154
20. Laemmli, U. K. (1970) Nature 227, 680-685
21. Matsudaira, P. (1987) J. Biol. Chem. 262, 10035-10038
22. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
23. Kar, S. R., Lebowitz, J., Blume, S., Taylor, K. B., and Hall, L. M. (2001) Biochemistry 40, 13378-13389
24. Shi, W., Wu, J., and Rosen, B. P. (1994) J. Biol. Chem. 269, 19826-19829
25. VanZile, M. L., Cosper, N. J., Scott, R. A., and Giedroc, D. P. (2000) Biochemistry 39, 11818-11829
26. Turner, J. S., Glands, P. D., Samson, A. C., and Robinson, N. J. (1996) Nucleic Acids Res. 24, 3714-3721
27. Shi, W., Dong, J., Scott, R. A., Ksenzenko, M. Y., and Rosen, B. P. (1996) J. Biol. Chem. 271, 9291-9297
28. Li, S., Rosen, B. P., Borges-Walmsley, M. I., and Walmsley, A. R. (2002) J. Biol. Chem. 277, 25992-26002
29. Helmann, J. D., Ballard, B. T., and Walsh, C. T. (1990) Science 247, 946-948
30. Rao, C. P., Dorfman, J. R., and Holm, R. H, (1986) Inorg. Chem. 25, 428-439
31. Archer, M., Carvalho, A. L., Teixeira, S., Moura, I., Moura, J. J., Rusnak, F., and Romao, M. J. (1999) Protein Sci, 8, 1536-1545
32. Mornet, D., Ue, K., and Morales, M. F. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 1658-1662
33. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680
34. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
35. Esnouf, R. M. (1997) J. Mol. Graph. Model. 15, 132-134, 112-113
36. Merrit, E. A., and Murphy, M. E. P. (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 869-873
37. Busenlehner, L. S., Apuy, J. L., and Giedroc, D. P. (2002) J. Biol. Inorg. Chem. 7, 551-559