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Volumn 13, Issue 9, 2002, Pages 975-981

Resolution and absolute configuration of bromofluoroacetic acid

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA METHYLBENZYLAMINE; BROMOFLUOROACETIC ACID; CHROMAN DERIVATIVE; EPOXYCHROMAN; FLUOROACETIC ACID; UNCLASSIFIED DRUG;

EID: 0037166705     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(02)00195-7     Document Type: Article
Times cited : (10)

References (38)
  • 7
  • 18
    • 0009525942 scopus 로고    scopus 로고
    • 2O of resolved 1 were unsuccessful
  • 29
    • 0009466258 scopus 로고    scopus 로고
    • note
  • 32
    • 0009531180 scopus 로고    scopus 로고
    • (S)-(-) and (R)-(+)-α-Methylbenzylamine, (1R,2S)-(-)-ephedrine, (1R,2R)-(-)-2-amino-1-(4-nitrophenyl)-1,3-propanediol, (1R,2R)-(-)-2-dimethylamino-1-(4-nitrophenyl)-1,3-propanediol, (-)-brucine, (-)-quinine and (-)-strychnine
  • 33
    • 0009530481 scopus 로고    scopus 로고
    • note
  • 34
    • 0009466128 scopus 로고    scopus 로고
    • Classical acidic hydrolysis of the salt in an aqueous solution followed by extraction with an organic solvent failed due to the solubility of 1 both in water and in common organic solvents. The acidic hydrolysis in non-aqueous media followed by distillation caused racemisation of the acid
  • 35
    • 0009534135 scopus 로고    scopus 로고
    • The specific rotation values and enantiomeric purities do not correlate exactly because the acid is highly hygroscopic and therefore always contains water
  • 36
    • 0009534136 scopus 로고    scopus 로고
    • Unfortunately we could not take advantage of this to carry out crystallisation-induced dynamic resolution (CIDR), due to the rapid decomposition of the compound in methanol


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.