Practical synthesis of chiral emopamil left hand as a bioactive motif

Journal of Organic Chemistry

Volumn 67, Issue 17, 2002, Pages 6228-6231

  Kimura, Teiji ^a   Yamamoto, Noboru ^a   Suzuki, Yuichi ^a   Kawano, Koki ^a   Norimine, Yoshihiko ^a   Ito, Koichi ^a   Nagato, Satoshi ^a   Iimura, Yoichi ^a   Yonaga, Masahiro ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-CATALYZED ISOMERIZATION; RACEMIZATION;

ALCOHOLS; ALDEHYDES; ISOMERIZATION; PURIFICATION;

SYNTHESIS (CHEMICAL);

EMOPAMIL; NITRILE; NOREMOPAMIL; UNCLASSIFIED DRUG; VERAPAMIL; 2 (2 ISOPROPYL) 5 HYDROXY 2 PHENYLPENTANENITRILE; 2-(2-ISOPROPYL)-5-HYDROXY-2-PHENYLPENTANENITRILE; DRUG DERIVATIVE; METHYL ALUMINUM BIS(4 METHYL 2,6 DI TERT BUTYLPHENOXIDE); METHYL ALUMINUM BIS(4-METHYL-2,6-DI-TERT-BUTYLPHENOXIDE); ORGANOMETALLIC COMPOUND;

ARTICLE; CHIRALITY; RACEMIC MIXTURE; REACTION ANALYSIS; STEREOCHEMISTRY; SYNTHESIS; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANIC CHEMISTRY; STEREOISOMERISM;

CATALYSIS; CHEMISTRY, ORGANIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; STEREOISOMERISM; VERAPAMIL;

EID: 0037162670     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo020166d     Document Type: Article

References (14)

1. Verapamil: A chiral challenge to the pharmacokinetic and pharamacodynamic assessment of bioavailability bioequivalence