Remission of HIV-associated myelopathy after initiation of lopinavir in a patient with extensive previous exposure to highly active antiretroviral therapy [8]

AIDS

Volumn 16, Issue 17, 2002, Pages 2367-2369

  Eyer Silva, Walter A ^a,b   Couto Fernandez, José Carlos ^b   Caetano, Marcelo R ^c   Chequer Fernandez, Saada L ^b   Pinto, Jorge Francisco C ^a   Morais de Sá, Carlos Alberto ^a   Morgado, Mariza G ^b  

^a HOSPITAL UNIVERSITÁRIO GAFFRÉE E GUINLE   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c Laboratório Cardiolab   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

INDINAVIR; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; NELFINAVIR; NEVIRAPINE; PROTEINASE INHIBITOR; SAQUINAVIR; STAVUDINE;

ADULT; CASE REPORT; CLINICAL FEATURE; DISEASE ASSOCIATION; DISEASE COURSE; DRUG WITHDRAWAL; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LABORATORY TEST; LETTER; MALE; PRIORITY JOURNAL; REMISSION; SPINAL CORD DISEASE; TREATMENT OUTCOME; VIRUS LOAD;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MALE; PYRIMIDINONES; SPINAL CORD DISEASES;

EID: 0037159909     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200211220-00031     Document Type: Letter

References (16)

1. Eyer-Silva WA, Auto I, Pinto JF, Morais-de-Sá CA. Spinal cord disorders in HIV-1-infected patients. Infect Dis Clin Pract 1999; 8:127-136.
2. Petito CK, Navia BA, Cho ES, Jordan BD, George DC, Price RW. Vacuolar myelopathy pathologically resembling subacute combined degeneration in patients with the acquired immunodeficiency syndrome. N Engl J Med 1985; 312:874-979.
3. Chong J, Di Rocco A, Tagliati M, Danisi F, Simpson DM, Atlas SW. MR findings in AIDS-associated myelopathy. Am J Neuroradiol 1999; 20:1412-1416.
4. Geraci A, Di Rocco A, Liu M, Werner P, Tagliati M, Godbold J, et al. AIDS myelopathy is not associated with elevated HIV viral load in cerebrospinal fluid. Neurology 2000; 55:440-442.
5. Staudinger R, Henry K. Remission of HIV myelopathy after highly active antiretroviral therapy. Neurology 2000; 54:267-268.
6. Eyer-Silva WA, Auto I, Pinto JF, Morais-de-Sá CA. Myelopathy in a previously asymptomatic HIV-1-infected patient. Infection 2001; 29:99-102.
7. Caride E, Brindeiro RM, Kallas EG, de Sa CA, Eyer-Silva WA, Machado E, Tanuri A. Sexual transmission of HIV-1 isolate showing G→A hypermutation. J Clin Virol 2002, 23:179-189.
8. Kempf DJ, Isaacson JD, King MS, Brun SC, Xu Y, Rear K, et al. Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. J Virol 2001; 75:7462-7469.
9. Tagliati M, Di Rocco A, Danisi F, Simpson DM. The role of somatosensory evoked potentials in the diagnosis of AIDS-associated myelopathy. Neurology 2000; 54;1477-1482.
10. Lafeuillade A, Solas C, Halfon P, Chadapaud S, Hittinger G, Lacarelle B. Differences in the detection of three HIV-1 protease inhibitors in non-blood compartments: Clinical correlations. HIV Clin Trials 2002; 3:27-35.
11. Weiser B, Peress N, La Neve D, Eilbott DJ, Seidman R, Burger H. Human immunodeficiency virus type 1 expression in the central nervous system correlates directly with extent of disease. Proc Natl Acad Sci U S A 1990; 87:3997-4001.
12. Petito CK, Vecchio D, Chen YT. HIV antigen and DNA in AIDS spinal cords correlate with macrophage infiltration but not with vacuolar myelopathy. J Neuropathol Exp Neurol 1994; 53:86-94.
13. Tan SV, Guiloff RJ. Hypothesis on the pathogenesis of vacuolar myelopathy, dementia, and peripheral neuropathy in AIDS. J Neurol Neurosurg Psychiatry 1998; 65:23-28.
14. Rusell JSR, Batten FE, Collier J. Subacute combined degeneration of the spinal cord. Brain 1900; 23:39-110.
15. Kamin SS, Petito CK. Idiopathic myelopathies with white matter vacuolation in non-acquired immunodeficiency syndrome patients. Hum Pathol 1991; 22:816-824.
16. 12deficiency. Arch Neurol 1971; 24:203-209.