Neuropeptide Y inhibits in vitro epileptiform activity in the entorhinal cortex of mice

Neuroscience Letters

Volumn 333, Issue 2, 2002, Pages 127-130

  Woldbye, D P D ^a,b   Nanobashvili, A ^a   Husum, H ^b   Bolwig, T G ^b   Kokaia, M ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Brain slice model; Entorhinal cortex; Epilepsy; Mouse; Neuropeptide Y; Zero magnesium

Indexed keywords

MAGNESIUM; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT THERAPY; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; ENTORHINAL CORTEX; EPILEPTIC DISCHARGE; HIPPOCAMPUS; IN VITRO STUDY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL;

ACTION POTENTIALS; ANIMALS; ANTICONVULSANTS; CULTURE MEDIA; ENTORHINAL CORTEX; EPILEPSY; MAGNESIUM DEFICIENCY; MALE; MICE; NEUROPEPTIDE Y; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES;

EID: 0037159590     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)01024-8     Document Type: Article

References (19)

1. Baraban S.C., Hollopeter G., Erickson J.C., Schwartzkroin P.A., Palmiter R.D. Knock-out mice reveal a critical antiepileptic role for neuropeptide Y. J. Neurosci. 17:1997;8927-8936.
2. Bijak M. Neuropeptide Y suppresses epileptiform activity in rat frontal cortex and hippocampus in vitro via different NPY receptor subtypes. Neurosci. Lett. 268:1999;115-118.
3. Bijak M. Neuropeptide Y reduces epileptiform discharges and excitatory synaptic transmission in rat frontal cortex in vitro. Neuroscience. 96:2000;487-494.
4. Erickson J.C., Clegg K.E., Palmiter R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 30:1996;415-421.
5. Gackenheimer S.L., Schober D.A., Gehlert D.R. Characterization of neuropeptide Y Y1-like and Y2-like receptor subtypes in the mouse brain. Peptides. 22:2001;335-341.
6. Gerald C., Walker M.W., Criscione L., Gustafson E.L., Batzl-Hartmann C., Smith K.E., Vaysse P., Durkin M.M., Laz T.M., Linemeyer D.L., Schaffhauser A.O., Whitebread S., Hofbauer K.G., Taber R.I., Branchek T.A., Weinshank R.L. A receptor subtype involved in neuropeptide Y-induced food intake. Nature. 382:1996;168-171.
7. Guo H., Castro P.A., Palmiter R.D., Baraban S.C. Y5 receptors mediate neuropeptide Y actions at excitatory synapses in area CA3 of the mouse hippocampus. J. Neurophysiol. 87:2002;558-566.
8. Ho M.W.Y., Beck-Sickinger A.G., Colmers W.F. Neuropeptide Y5 receptors reduce synaptic excitation in proximal subiculum, but not epileptiform activity in rat hippocampal slices. J. Neurophysiol. 83:2000;723-734.
9. Kendrick K.M. Microdialysis measurement of in vivo neuropeptide release. J. Neurosci. Methods. 34:1990;35-46.
10. Klapstein G.J., Colmers W.F. On the sites of presynaptic inhibition by neuropeptide Y in rat hippocampus in vitro. Hippocampus. 3:1993;103-111.
11. Kokaia M., Asztely F., Olofsdotter K., Sindreu C.B., Kullmann D.M., Lindvall O. Endogenous neurotrophin-3 regulates short-term plasticity at lateral perforant path-granule cell synapses. J. Neurosci. 18:1998;8730-8739.
12. Köhler C. Cytochemical architecture of the entorhinal cortex. Adv. Exp. Med. Biol. 203:1986;83-98.
13. Marsh D.J., Baraban S.C., Hollopeter G., Palmiter R.D. Role of the Y5 neuropeptide Y receptor in limbic seizures. Proc. Natl. Acad. Sci. USA. 96:1999;13518-13523.
14. Trivedi P.G., Yu H., Trumbauer M., Chen H., Van der Ploeg L.H.T., Guan X.-M. Differential regulation of neuropeptide Y receptors in the brains of NPY knock-out mice. Peptides. 22:2001;395-403.
15. Vezzani A., Michaelkiewicz M., Michaelkiewicz T., Moneta D., Ravizza T., Richichi C., Aliprandi M., Mulé F., Pirona L., Gobbi M., Schwarzer C., Sperk G. Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y. Neuroscience. 110:2002;237-243.
16. Vezzani A., Sperk G., Colmers W.F. Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci. 22:1999;25-30.
17. Witter M.P., Wouterlood F.G., Naber P.A., Van Haeften T. Anatomical organization of the parahippocampal-hippocampal network. Ann. N. Y. Acad. Sci. 911:2000;1-24.
18. Woldbye D.P.D., Larsen P.J., Mikkelsen J.D., Klemp K., Madsen T.M., Bolwig T.G. Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. Nat. Med. 3:1997;761-764.
19. Woldbye D.P.D., Larsen P.J., Mikkelsen J.D., Madsen T.M., Bolwig T.G. Neuropeptide Y inhibits hippocampal seizures and wet dog shakes. Brain Res. 737:1996;162-168.