Structure-activity relationship studies with (±)-nantenine derivatives for α1-adrenoceptor antagonist activity

European Journal of Pharmacology

Volumn 437, Issue 3, 2002, Pages 173-178

  Indra, Bachtiar ^a   Matsunaga, Kimihiro ^a   Hoshino, Osamu ^b   Suzuki, Masaji ^b   Ogasawara, Hiromichi ^b   Ohizumi, Yasushi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

1 Adrenoceptor; ( ) Nantenine derivatives; Aorta, Rat

Indexed keywords

4ALPHA HYDROXYNANTENINE; 4BETA HYDROXYNANTENINE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; APORPHINE DERIVATIVE; BOLDINE; DOMESTICINE; ETHYLNORNANTENINE; FUNCTIONAL GROUP; HYDROGEN; HYDROXYL GROUP; INOSITOL PHOSPHATE; METHYL GROUP; N TRIFLUOROACETYLDOMESTICINE; N TRIFLUOROACETYLNORNANTENINE; NANTENINE; NORDOMESTICINE; NORNANTENINE; PHENYLEPHRINE; UNCLASSIFIED DRUG;

ADRENERGIC ACTIVITY; ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; STRUCTURE ACTIVITY RELATION;

ADRENERGIC ANTAGONISTS; ANIMALS; AORTA, THORACIC; APORPHINES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; INOSITOL PHOSPHATES; MALE; PHENYLEPHRINE; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 0037154562     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01303-1     Document Type: Article

References (18)

1. Some quantitative uses of drug antagonist
2. Antipolivirus structure-activity relationships of some aporphine alkaloids
3. Mechanism of the cardiovascular activity of laudanosine: Comparison with papaverine and other benzylisoquinoline
4. 1-adrenoceptor of the guinea-pig aorta
5. Medicines from nature: Are natural products still relevant to drug discovery?
6. International union of pharmacology: X. Recommendation for nomenclature of alpha 1-adrenoceptors: Consensus update
7. Studies on tetrahydroiso quinolines: IX. The synthesis of (+)-domesticine and a related (+)-homoaporphine via p-quinol acetates
8. A novel synthesis of (±)-noraporphine alkaloids (±)-wilsonirine and (±)-nordomesticine
9. 1-adrenoceptor and benzothiazepine binding site at the calcium channel
10. Investigation of the dual contractile/relaxant properties showed by antiquine in rat aorta
11. 1-adrenoceptor and 5-hydroxytriptamine receptor antagonists, isolated from Fissistigma gluacescens
12. 1D-adrenoceptor antagonist, isolated from Fissistigma gluacescens
13. 1A-adrenoceptor subtype
14. 1A-adrenoceptors in rat cerebral cortex
15. Thromboxane A2 activates phospholipase C in astrocytoma cells via pertusis toxin-insensitive G-protein
16. Lead tetra acetate oxidation of (+)-N-acylnoraporphines: Facile synthesis of 4α-hydroxynor aporphines and 4α-hydroxyaporphines
17. The A10 cell line: A model for neonatal, neointimal, or differentiated vascular smooth muscle cells?
18. Serotonergic receptor antagonist from Nandina domestica Thunberg