One-trial tolerance to the effects of chlordiazepoxide in the elevated plus-maze is not due to acquisition of a phobic avoidance of open arms during initial exposure

Life Sciences

Volumn 71, Issue 5, 2002, Pages 519-525

  Frussa Filho, R ^a   Ribeiro, R Dea ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anxiety; Chlordiazepoxide; Elevated plus maze; Phobia; Tolerance

Indexed keywords

ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; CHLORDIAZEPOXIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERANCE; MALE; MAZE TEST; NONHUMAN; PHOBIA; RAT; TASK PERFORMANCE;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; BEHAVIOR, ANIMAL; CHLORDIAZEPOXIDE; DRUG TOLERANCE; MALE; MAZE LEARNING; PHOBIC DISORDERS; RANDOM ALLOCATION; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0037150778     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)01709-5     Document Type: Article

References (16)

1. Effects of long-term ganglioside GM1 administration on a new discriminative avoidance test in normal adult mice
2. The plus-maze discriminative avoidance task: A new model to study memory-anxiety interactions. Effects of chlordiazepoxide and caffeine
3. Effects of diazepam on behavioural and antinociceptive responses to the elevated plus-maze in male mice depend upon treatment regimen and prior maze experience
4. Anxiety-induced antinociception in the mouse
5. Plus-maze retest profile in mice: Importance of initial stages of trial 1 and response to post-trial cholinergic receptor blockade
6. Characterization of the phenomenon of "one-trial tolerance" to the anxiolytic effect of chlordiazepoxide in the elevated plus-maze
7. Trial 2 in the elevated plus-maze: A different form of fear?
8. Influence of prior maze experience on behaviour and response to diazepam in the elevated plus-maze and light/dark tests of anxiety in mice
9. A five minute experience in the elevated plus-maze alters the state of benzodiazepine receptor in the dorsal raphe nucleus
10. Naltrexone potentiates the anxiolytic effects of chlordiazepoxide in rats exposed to novel environments
11. The phenomenon of "one-trial tolerance" to the anxiolytic effect of chlordiazepoxide in the elevated plus-maze is abolished by the introduction of a motivational conflict situation
12. Previous maze experience required to increase open arms avoidance in rats submitted to the elevated plus-maze model of anxiety
13. Validation of open:closed arm entries in an elevated plus-maze as measure of anxiety in the rats
14. Influence of spatial and temporal manipulations on the anxiolytic efficacy of chlordiazepoxide in mice previously exposed to the elevated plus-maze
15. One-trial tolerance to the effects of chlordiazepoxide on the elevated plus maze may be due to locomotor habituation, not repeated drug exposure
16. Immediate increase in benzodiazepine binding in rat brain after a single brief experience in the plus-maze: A paradoxical effect