Substitution of Met-69 by Ala or Gly in TEM-1 β-lactamase confer an increased susceptibility to clavulanic acid and other inhibitors

FEMS Microbiology Letters

Volumn 211, Issue 1, 2002, Pages 13-16

  Madec, Stéphanie ^a   Blin, Claudine ^b   Krishnamoorthy, Rajagopal ^b   Picard, Bertrand ^c   Chaibi, El Bachir ^a   Fouchereau Péron, Martine ^a   Labia, Roger ^a  

^a CNRS   (France)

^b HÔPITAL ROBERT DEBRÉ   (France)

^c CHU MORVAN   (France)

Author keywords

Lactamase; Lactamase inhibitors; Site directed mutagenesis

Indexed keywords

ALANINE; AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; BETA LACTAMASE TEM 1; CEFALOTIN; CEFOPERAZONE; CEFOTAXIME; CEFOXITIN; CEPHALOSPORIN DERIVATIVE; CLAVULANIC ACID; GLYCINE; IMIPENEM; ISOLEUCINE; LEUCINE; METHIONINE; METHIONINE 69; PENICILLIN G; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; SULBACTAM; TAZOBACTAM; TICARCILLIN; TIMENTIN; UNCLASSIFIED DRUG; VALINE; ANTIINFECTIVE AGENT; BETA-LACTAMASE TEM-1;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; BACILLUS CEREUS; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME BINDING; ENZYME STRUCTURE; ENZYME SUBSTRATE; IC 50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SITE DIRECTED MUTAGENESIS; SPECIES DIFFERENCE; STAPHYLOCOCCUS AUREUS; STREPTOMYCES; WILD TYPE; ANTIBIOTIC RESISTANCE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; HYDROLYSIS; KINETICS; METABOLISM; MICROBIOLOGICAL EXAMINATION; MUTATION;

ALANINE; AMINO ACID SUBSTITUTION; ANTIBIOTICS, LACTAM; BETA-LACTAMASES; CLAVULANIC ACID; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; GLYCINE; HYDROLYSIS; INHIBITORY CONCENTRATION 50; KINETICS; METHIONINE; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS, SITE-DIRECTED; MUTATION; SUBSTRATE SPECIFICITY; ANTI-BACTERIAL AGENTS;

EID: 0037150025     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(02)00645-6     Document Type: Article

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