Prediction of plasma concentration-time curve of orally administered theophylline based on a scintigraphic monitoring of gastrointestinal transit in human volunteers

International Journal of Pharmaceutics

Volumn 233, Issue 1-2, 2002, Pages 179-190

  Haruta, Shunji ^a,b   Kawai, Keiichi ^a   Nishii, Ryuichi ^a   Jinnouchi, Seishi ^a   Ogawara, Ken Ichi ^b   Higaki, Kazutaka ^b   Tamura, Shozo ^a   Arimori, Kazuhiko ^a   Kimura, Toshikiro ^b  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Gamma scintigraphy; Gastrointestinal transit; GI transit absorption model; Human; Oral absorption; Prediction of absorption profile

Indexed keywords

AMINOPHYLLINE; BIOLOGICAL MARKER; DIPROPHYLLINE; PENTETATE TECHNETIUM TC 99M; THEOPHYLLINE;

ADULT; ARTICLE; BIOLOGICAL MONITORING; CECUM; CLINICAL TRIAL; COLON; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET RESTRICTION; DRUG ABSORPTION; DRUG BLOOD LEVEL; FEEDING; GAMMA SCINTIGRAPHY; GASTROINTESTINAL TRANSIT; HUMAN; HUMAN EXPERIMENT; ILEUM; JEJUNUM; MALE; NONHUMAN; NORMAL HUMAN; PREDICTION; PRIORITY JOURNAL; RAT; STOMACH; STOMACH EMPTYING;

ADMINISTRATION, ORAL; ADULT; BRONCHODILATOR AGENTS; CROSS-OVER STUDIES; DIGESTIVE SYSTEM; FOOD-DRUG INTERACTIONS; GASTROINTESTINAL TRANSIT; HUMANS; LINEAR MODELS; MALE; MONITORING, PHYSIOLOGIC; PREDICTIVE VALUE OF TESTS; THEOPHYLLINE; TIME FACTORS;

EID: 0037148655     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00942-5     Document Type: Article

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