Advantages of continuous over batch reactors for the kinetic analysis of enzymes inhibited by an unknown substrate impurity

Biotechnology and Bioengineering

Volumn 79, Issue 6, 2002, Pages 641-646

  Gallifuoco, Alberto ^a   Alfani, Francesco ^a   Cantarella, Maria ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Continuous reactor; Enzyme inhibition; Impure substrate; Mathematical modeling; Steadystate stability

Indexed keywords

COMPUTER SIMULATION; ENZYME KINETICS; STABILITY; SUBSTRATES;

CONTINUOUS STIRRED-TANK REACTOR;

BIOTECHNOLOGY;

ENZYME; ENZYME INHIBITOR;

ARTICLE; BATCH REACTOR; COMPETITIVE INHIBITION; ENZYME INHIBITION; ENZYME KINETICS; MATHEMATICAL MODEL; SIMULATION; TECHNIQUE; BIOLOGICAL MODEL; BIOREACTOR; CHEMICAL MODEL; COMPUTER SIMULATION; ENZYME ACTIVATION; ENZYME SPECIFICITY; METABOLISM; QUALITY CONTROL; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

BIOREACTORS; COMPUTER SIMULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYMES; MODELS, BIOLOGICAL; MODELS, CHEMICAL; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T;

EID: 0037144085     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10326     Document Type: Article

References (10)

1. Study of Michaelis-Menten kinetics with linear-type product inhibition in ultrafiltration membrane reactors: Mathematical model, experimental and data correlation
2. Membrane reactors for the investigation of product inhibition of enzyme activity
3. Sucrose bioconversion in membrane reactors
4. Product inhibition studies in membrane reactors
5. Concentration stability of the isothermal reactor
6. Operational range for continuous stirred tank bioreactor degrading an inhibitory substrate
7. Multiple steady state in continuous flow stirred tank enzyme reactors
8. Fixed-bed reactor design for self-inhibitory substrates
9. A method of graphically analyzing substrate-inhibition kinetics