Increased emotional distress in daughters of breast cancer patients is associated with decreased natural cytotoxic activity, elevated levels of stress hormones and decreased secretion of Th1 cytokines

International Journal of Cancer

Volumn 100, Issue 3, 2002, Pages 347-354

  Cohen, Miri ^a,b   Klein, Ehud ^a   Kuten, Abraham ^a   Fried, Geta ^a   Zinder, Oren ^a   Pollack, Shimon ^a  

^a RAMBAM MEDICAL CENTER   (Israel)

^b UNIVERSITY OF HAIFA   (Israel)

Author keywords

Chronic stress; Daughters of breast cancer patients; Natural cytotoxic activity; Stress hormones; Th1 cytokines

Indexed keywords

CATECHOLAMINE; CYTOKINE; GAMMA INTERFERON; HORMONE; HYDROCORTISONE; INTERLEUKIN 12; INTERLEUKIN 2; NORADRENALIN;

ADULT; ARTICLE; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; COPING BEHAVIOR; CYTOKINE RELEASE; CYTOTOXICITY; EMOTIONAL STRESS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNE SYSTEM; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGENY; PSYCHOLOGICAL ASPECT; QUESTIONNAIRE;

ADULT; AFFECTIVE SYMPTOMS; BREAST NEOPLASMS; CATECHOLAMINES; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; HUMANS; HYDROCORTISONE; KILLER CELLS, NATURAL; LEUKOCYTE COUNT; MIDDLE AGED; NUCLEAR FAMILY; TH1 CELLS;

EID: 0037143111     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10488     Document Type: Article

References (54)

1. Role of NK cells in the control of metastatic spread and growth of tumor cells in mice
2. Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity
3. Natural killer cells: Their role in defense against disease
4. Natural killer cells and cancer
5. Low natural-killer-cell activity in familial melanoma patients and their relatives
6. Low natural cytotoxicity of peripheral blood mononuclear cells in individuals with high familial incidences of cancer
7. Relationship between natural killer activity and development of hepatocellular carcinoma in patients with cirrhosis of liver
8. Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters
9. Natural killer cell activity in patients with hepatocellular carcinoma: A new prognostic indicator after hepatectomy
10. Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: An 11-year follow-up of a general population
11. Reducing the risk of breast cancer
12. Adverse life events and breast cancer: Case-control study
13. Life events prior to manifestation of breast cancer: A limited prospective study covering eight years before diagnosis
14. Adverse life events and risk of breast cancer: A meta-analysis
15. Are life events related to the onset of breast cancer?
16. Stressful life events and onset of breast cancer: Case-control study
17. Psychological functioning of daughters of breast cancer patients. Part II: Characterizing the distressed daughter of the breast cancer patient
18. How daughters of women with breast cancer cope with the threat of the illness
19. Spousal caregivers of dementia victims: Longitudinal changes in immunity and health
20. Chronic stress, social support, and persistent alterations in the natural killer cell response to cytokines in older adults
21. Stress and the individual. Mechanisms leading to disease
22. Experimental basis for neural-immune interactions
23. In vivo modulation of natural killer cell activity by tamoxifen in patients with bilateral primary breast cancer
24. Natural killer cell activity in post-necrotic cirrhotic patients as related to hepatitis-B virus infection and plasma zinc levels
25. Calculation of lytic units for the expression of cell-mediated cytotoxicity
26. Natural killer cell activation-associated induction of target cell DNA fragmentation in a spontaneously regressing rat histiocytoma
27. Monocyte-regulated IFN-gamma production in human T cells involves CD2 signaling
28. IL-12 reverses cytokine and immune abnormalities in Sezary syndrome
29. Interleukin-12 production by human polymononuclear leukocytes
30. The SCL-90 and the MMPI: A step in the validation of a new self-report scale
31. An analysis of coping in a middle-aged community sample
32. Locus of control, cognitive appraisal, and coping in stressful episodes
33. Single-sample tests for many correlations
34. Stress and immune responses after surgical treatment for regional breast cancer
35. Stress and immunity in humans: A meta-analytic review
36. Familial occurrence of breast cancer is associated with reduced natural killer cytotoxicity
37. Studies on functional status of circulating lymphocytes in unaffected members from cancer families
38. Natural killer cell activity in women at "high risk" for breast cancer, with and without benign breast syndrome
39. Familial cancer, emotional distress, and low natural cytotoxic activity in healthy women
40. Interleukin 4 (IL-4) blocks the IL-2-induced increased in natural killer activity and DNA synthesis of decidual CD16-CD56bright NK cells by inhibiting expression of the IL-2 receptor alpha, beta, and gamma
41. Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: Clinical implications
42. Cytokine-induced cytotoxic function expressed by lymphocytes of the innate immune system: Distinguishing characteristics of NK and LAK based on functional and molecular markers
43. Stress depresses interferon production by leukocytes concomitant with a decrease in natural killer cell activity
44. The influence of psychological stress on the immune response to vaccines
45. Chronic stress in caregivers of dementia patients is associated with reduced lymphocyte sensitivity to glucocortcoids
46. cAMP-dependent protein kinase (PKA) inhibits T cell activation by phosphorylating ser-43 of raf-1 in the MAPK/ERK pathway
47. Costimulatory signals modulate the antiproliferative effects of agents that elevate cAMP in T cells
48. Catecholamines modulate human NK cell circulation and function via spleen-independent beta-2 adrenergic mechanisms
49. Modulation of the immunologic response to acute stress in humans by beta-blockade or benzodiazepines
50. Psychological functioning of daughters of breast cancer patients. Part I: Daughters and comparison subjects
51. Younger women at increased risk for breast cancer: Perceived risk, psychological well-being, and surveillance behavior
52. Psychological distress and surveillance behaviors of women with a family history of breast cancer