Acylating agents as enzyme inhibitors and understanding their reactivity for drug design

Journal of Medicinal Chemistry

Volumn 45, Issue 13, 2002, Pages 2850-2856

  Sykes, Nicholas O ^a   Macdonald, Simon J F ^b   Page, Michael I ^a  

^a UNIVERSITY OF HUDDERSFIELD   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; GAMMA LACTAM DERIVATIVE; GAMMA LACTONE DERIVATIVE; LEUKOCYTE ELASTASE INHIBITOR;

ACYLATION; ARTICLE; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; DIAGNOSTIC VALUE; DRUG DESIGN; ENERGY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROLYSIS; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ACYLATION; BICYCLO COMPOUNDS, HETEROCYCLIC; DRUG DESIGN; HYDROLYSIS; KINETICS; LACTAMS; LACTONES; PANCREATIC ELASTASE; PROPANOLS; SERINE PROTEINASE INHIBITORS; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TRIFLUOROETHANOL; WATER;

EID: 0037142303     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0111245     Document Type: Article

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