Alpha-alkylcysteines as inhibitors for carboxypeptidase A. Synthesis, evaluation, and implication for inhibitor design strategy

Bulletin of the Korean Chemical Society

Volumn 23, Issue 4, 2002, Pages 593-598

  Lee, Hyun Soo ^a   Kim, Dong H ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Carboxypeptidase A; Enzyme inhibition; Hydrogen bonding; Steric hindrance

Indexed keywords

2 BENZYL 3 MERCAPTOPROPANOIC ACID; 2 BENZYLCYSTEINE; 2 PHENETHYLCYSTEINE; AMINE; CARBOXYLIC ACID DERIVATIVE; CARBOXYPEPTIDASE A; CARBOXYPEPTIDASE A INHIBITOR; CYSTEINE DERIVATIVE; GLUTAMINE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXYLATION; CHEMICAL INTERACTION; COMPETITIVE INHIBITION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; HYDROGEN BOND; INHIBITION KINETICS; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

EID: 0037140519     PISSN: 02532964     EISSN: None     Source Type: Journal    
DOI: 10.5012/bkcs.2002.23.4.593     Document Type: Article

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